Abstract：
:Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the enteric characteristics, an in vitro dissolution test was performed with the AQ6-AP microspheres; 95% of the A. pleuropneumoniae protein was released within 3 h at pH 7, but there was no release at pH 1.5. The scanning microscopy revealed that the surface structure of AQ6-AP microspheres became porous at neutral pH. The SDS-PAGE analysis showed that the release rate of proteins from the microspheres was pH dependent not only for the AQ6-AP formulation but also when antigens of A. pleuropneumoniae were replaced with porcine serum. The results suggest that the A. pleuropneumoniae antigens were entrapped in the AQ6 microspheres under the acidic conditions. In a mouse model, oral immunization with AQ6-AP microspheres containing A. pleuropneumoniae evoked systemic IgG and mucosal IgA responses against A. pleuropneumoniae antigens. Thus, the present method may further provide an opportunity to develop oral vaccines and mucosal immunity.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Liao CW,Cheng IC,Yeh KS,Lin FY,Weng CNdoi
10.1080/02652040010019442subject
Has Abstractpub_date
2001-05-01 00:00:00pages
285-97issue
3eissn
0265-2048issn
1464-5246journal_volume
18pub_type
杂志文章abstract：:Water-in-oil-in-water multiple emulsions of chloroquine diphosphate were prepared, using olive oil, arachis oil, Span 80, gelatin, acacia and Tween 80. Emulsifiers were employed individually or in combination. An attempt was made to correlate preparative variables with stability and drug release of multiple emulsions ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049409051115
更新日期：1994-11-01 00:00:00
abstract：:Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1692946
更新日期：2020-01-01 00:00:00
abstract：:The effects of different loading procedures of magnetic nanoparticles (MNs) on the structure and physicochemical properties of cisplatin magnetic liposomes were investigated by X-ray diffraction, infrared spectroscopy, transmission electron microscopy, and fluorescence spectroscopy. 1, 2-Dipalmitoyl-sn-glycero-3-Phosp...
journal_title：Journal of microencapsulation
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doi：10.3109/02652048.2012.692397
更新日期：2012-01-01 00:00:00
abstract：:Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1248512
更新日期：2016-12-01 00:00:00
abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1409819
更新日期：2018-01-01 00:00:00
abstract：:The objective of this study was to prepare a microparticulate drug delivery system being based on a new thiomer, namely a chitosan 2-iminothiolane conjugate (chitosan-TBA conjugate). Due to thiol groups being immobilized on chitosan, chitosan-TBA conjugate exhibits improved mucoadhesive and permeation enhancing proper...
journal_title：Journal of microencapsulation
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doi：10.1080/02652040500162220
更新日期：2005-08-01 00:00:00
abstract：:The in vivo absorption of crystalline nitrofurantoin and the dosage forms of nitrofurantoin prepared with microcapsules were carried out in man by determination of urinary excretion of unchanged nitrofurantoin. The cumulative amount of drug excreted and the duration of the therapeutic urine levels were compared. The m...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049409040444
更新日期：1994-03-01 00:00:00
abstract：:This study explored a liquid phase coating technique to produce polymethyl methacrylate (PMMA)-coated alginate microspheres. Alginate microspheres with a mean diameter of 85.6 microm were prepared using an emulsification method. The alginate microspheres, as cores, were then coated with different types of PMMA by a li...
journal_title：Journal of microencapsulation
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doi：10.1080/02652040500273936
更新日期：2005-12-01 00:00:00
abstract：:The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads coul...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040050161729
更新日期：2000-11-01 00:00:00
abstract：CONTEXT:Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. OBJECTIVE:To prepare and characterise tamoxifen (TAM)-loaded SLNs. MATERIALS AND METHODS:Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), tra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.898707
更新日期：2014-01-01 00:00:00
abstract：:The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049209021219
更新日期：1992-01-01 00:00:00
abstract：:Enteric diastase spherules were prepared using cellulose acetate phthalate and eudragit RS-100 by emulsion solvent removal method. Factors that could affect the size shape and diastatic activity were studied. The studied factors include pH of aqueous media, temperature of dispersion media and concentration of surface ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049109021868
更新日期：1991-10-01 00:00:00
abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000093096
更新日期：2003-07-01 00:00:00
abstract：:Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000151974
更新日期：2003-09-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028419
更新日期：1990-01-01 00:00:00
abstract：:The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied. The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism. Micro-pellets produced were sieved into several fractions and...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500100345
更新日期：2005-05-01 00:00:00
abstract：:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...
journal_title：Journal of microencapsulation
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doi：10.3109/02652040903515508
更新日期：2010-01-01 00:00:00
abstract：:In this study microspheres of diclofenac sodium, an anti-inflammatory agent, were prepared by utilizing a natural polysaccharide, chitosan-H. The objective of this investigation was to sustain the action of diclofenac sodium and to show the effect of various conditions on release kinetics. For this reason factorial de...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：1996-03-01 00:00:00
abstract：:The preparation of dipyridamole (DIP) alginate (alg) microspheres by different methods or the incorporation of tragacanth (trgh), pectin or Eudragit L-100 55 (Eud) in alg microsphere formulations did not provide a prolonged release of DIP at pH 1.2. Tabletted microsphere formulations containing alg, trgh, pectin, sodi...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499288906
更新日期：1999-07-01 00:00:00
abstract：:Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1720030
更新日期：2020-05-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.1080/026520499288799
更新日期：1999-09-01 00:00:00
abstract：:Vascular endothelial growth factor receptor (VEGFR) is over-expressed on a variety of tumour cells and tumour neovasculature, and so becomes well-documented target for cancer treatment. This study was designed to evaluate the cellular targeting and anti-tumor potency of VEGF-conjugated nanoparticles (VEGF-NPs). The po...
journal_title：Journal of microencapsulation
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doi：10.3109/02652048.2015.1035683
更新日期：2015-01-01 00:00:00
abstract：:This article describes the development of a freeze-dried formulation of chitosan (CS) nanocapsules containing docetaxel (DCX) and the evaluation of its efficacy in the NCI-H460 cancer cell line. More specifically, two prototypes of nanocapsules differing in their coating, CS alone or in combination with poloxamer 188 ...
journal_title：Journal of microencapsulation
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doi：10.3109/02652048.2012.714411
更新日期：2013-01-01 00:00:00
abstract：:The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499289077
更新日期：1999-05-01 00:00:00
abstract：:The aim of this work was to investigate the role of HLB of emulsifier as well as volume of the internal aqueous phase (W(1)) and presence of salt in the external aqueous phase (W(2)) on the morphology, size and encapsulation efficiency of poly(D,L-lactide) microspheres containing naltrexone HCl. PLA microparticles con...
journal_title：Journal of microencapsulation
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更新日期：2005-03-01 00:00:00
abstract：:The objective of this work was to prepare and evaluate ketoprofen-loaded albumin microspheres for intramuscular administration. Microspheres were prepared by emulsion cross-linking method using a 2(3) factorial design and the effect of different factors on entrapment efficiency was determined. Microspheres were evalua...
journal_title：Journal of microencapsulation
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更新日期：2009-08-01 00:00:00
abstract：:Prototype fragrances, prepared from common fragrance components, were extracted with water, recovered, and characterized by gas chromatography before and after the water treatment, revealing a significant loss of the more water-soluble components. Unextracted prototype fragrances were also microencapsulated by a gelat...
journal_title：Journal of microencapsulation
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doi：10.3109/02652049209021244
更新日期：1992-07-01 00:00:00
abstract：:H-n.m.r. spectroscopy of small unilamellar phospholipid vesicles in the presence of the lanthanide probe ion Dy3+ has been used to study the permeability of these liposomes induced by the bile salts (glycocholate and glycodeoxycholate) and pancreatic phospholipase A2. A marked synergism is demonstrated in the combined...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048409038515
更新日期：1984-04-01 00:00:00
abstract：:This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical character...
journal_title：Journal of microencapsulation
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doi：10.1080/02652048.2016.1260659
更新日期：2016-12-01 00:00:00
