Sustained-release dosage form of nitrofurantoin. Part 2. In vivo urinary excretion in man.


:The in vivo absorption of crystalline nitrofurantoin and the dosage forms of nitrofurantoin prepared with microcapsules were carried out in man by determination of urinary excretion of unchanged nitrofurantoin. The cumulative amount of drug excreted and the duration of the therapeutic urine levels were compared. The microcapsule administration showed that the peak reached during the excretion of nitrofurantoin in urine, decreased significantly when compared to the pure drug. This could be an explanation for the decrease in side-effects of nitrofurantoin such as nausea and vomiting. Experiments in male albino rats showed that the microcapsules did not produce gastric haemorrhage seen with the same doses of the pure drug.


J Microencapsul


Ertan G,Karasulu E,Abou-Nada M,Tosun M,Ozer A




Has Abstract


1994-03-01 00:00:00












  • Effects of tremella-alginate-liposome encapsulation on oral delivery of inactivated H5N3 vaccine.

    abstract::In this study, we evaluated a system for oral vaccine delivery, consisting of liposomes coated first with a layer of tremella and then with an outer layer of acid-induced alginate. In vitro release studies showed that the triple layer of alginate-tremella-liposomes was more resistant to an acidic pH and modulated the ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Cheng HC,Chang CY,Hsieh FI,Yeh JJ,Chien MY,Pan RN,Deng MC,Liu DZ

    更新日期:2011-01-01 00:00:00

  • Sorption of 5-fluorouracil from aqueous solutions onto methyl methacrylate nanoparticles.

    abstract::The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solut...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yalabik-Kas HS,Kreuter J,Hincal AA,Speiser PP

    更新日期:1986-04-01 00:00:00

  • Protein-loaded poly(epsilon-caprolactone) microparticles. II. Muramyl dipeptide for oral controlled release of adjuvant.

    abstract::This work investigated the means for the efficient encapsulation of muramyl dipeptide (MDP) in poly(epsilon-caprolactone) (PCL) microparticles (MP) by a solvent evaporation method in order to optimize the effect of the adjuvant for oral immunization. Therefore, the influence of MDP concentration in the inner aqueous p...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Youan BB,Benoit MA,Rollmann B,Riveau G,Gillard J

    更新日期:1999-09-01 00:00:00

  • Preparation of TTO/UF resin microcapsule via in situ polymerisation and modelling of its slow release.

    abstract::For slow release of tea tree oil (TTO), TTO were encapsulated by urea-formaldehyde (UF) resin via in situ polymerisation. The effects of curing time and drying condition on particle size, and TTO loading of the TTO/UF microcapsules were investigated. The results indicated that TTO/UF resin microcapsules with curing ti...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Huang Q,Gong S,Han W,Chen Y,Shu X

    更新日期:2020-06-01 00:00:00

  • Application of encapsulated enzyme as a continuous packed-bed reactor.

    abstract::In the previous report, microencapsulation of lipase employing a (w/o)/w multiple phase emulsion technique, with 2:1 polystyrene (PS)-SBR mixture being used as a wall material, was proposed. Catalysis of the encapsulated enzyme was investigated, and the hydrolysis of triacetin (triglyceride of acetic acid) was success...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Iso M,Shirahase T,Hanamura S,Urushiyama S,Omi S

    更新日期:1989-07-01 00:00:00

  • Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation.

    abstract::Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Shu XZ,Zhu KJ

    更新日期:2001-03-01 00:00:00

  • Sulindac loaded alginate beads for a mucoprotective and controlled drug release.

    abstract::Ionotropic gelation was used to entrap sulindac into calcium alginate beads as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Beads were investigated in vitro for a possible sustained drug release and their use in vivo as a gastroprotective system for sulindac. Process parameters such a...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yegin BA,Moulari B,Durlu-Kandilci NT,Korkusuz P,Pellequer Y,Lamprecht A

    更新日期:2007-06-01 00:00:00

  • Preparation and cellular targeting study of VEGF-conjugated PLGA nanoparticles.

    abstract::Vascular endothelial growth factor receptor (VEGFR) is over-expressed on a variety of tumour cells and tumour neovasculature, and so becomes well-documented target for cancer treatment. This study was designed to evaluate the cellular targeting and anti-tumor potency of VEGF-conjugated nanoparticles (VEGF-NPs). The po...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Shi Y,Zhou M,Zhang J,Lu W

    更新日期:2015-01-01 00:00:00

  • Sterilization of contrast media (Isovist) containing liposomes by ethylene oxide.

    abstract::Liposomes containing Isovist were prepared by controlled detergent dialysis as well as by reverse phase evaporation. After preparation these liposomes were lyophilized and then submitted to sterilization by ethylene oxide. Prior to lyophilization, trehalose was added as a protective agent to preserve the size of the l...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ratz H,Freise J,Magerstedt P,Schaper A,Preugschat W,Keyser D

    更新日期:1989-10-01 00:00:00

  • Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55.

    abstract:PURPOSE:Naproxen CR tablets have been obtained from its microspheres prepared by coprecipitation with Eudragit L100-55. The purpose of this work was to evaluate the main and interaction effects of deaggregating agent concentration (X1), compression pressure (X2) and amount of precipitating water (X3) on naproxen releas...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Zaghloul AA,Vaithiyalingam SR,Faltinek J,Reddy IK,Khan MA

    更新日期:2001-09-01 00:00:00

  • Phase separation modulation and aggregation prevention: mechanism of the non-solvent addition method in the presence and absence of polyisobutylene as an additive.

    abstract::The mechanism by which microcapsule aggregation is diminished in the presence of low concentrations of adjunct non-walling polymers such as polyisobutylene (PIB) in organic solvents is uncertain. It is here investigated by phase separation studies employing the non-solvent addition method (cyclohexane) in parallel wit...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Donbrow M,Hoffman A,Benita S

    更新日期:1990-01-01 00:00:00

  • Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection.

    abstract::The aim was to study the effect of the type of polymer solvent on characteristics of microspheres produced by spray drying. The water-soluble model protein, bovine serum albumin (BSA) was microencapsulated into biodegradable poly(D,L-lactic acid) using the following 10 different polymer solvents: acetaldehyde dimethyl...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gander B,Wehrli E,Alder R,Merkle HP

    更新日期:1995-01-01 00:00:00

  • Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system.

    abstract::The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive propertie...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Songsurang K,Siraleartmukul K,Muangsin N

    更新日期:2015-01-01 00:00:00

  • Preparation and characterization of liposome-encapsulated haemoglobin by a freeze-thaw method.

    abstract::Haemoglobin (Hb) was encapsulated into liposomes as a blood substitute by a freeze-thaw method. The encapsulation efficiency was affected by the Hb/lipid ratio, starting Hb concentration, pH and salt concentration. Liposome-encapsulated haemoglobin (LEH) prepared by this method contains 5-10 mM Hb with 4-10 per cent m...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Liu L,Yonetani T

    更新日期:1994-07-01 00:00:00

  • 99mTc-labelled monodisperse latex particles coated with amino or carboxyl groups for studies of GI function.

    abstract::Latex particles coated with either amino or carboxyl groups were labelled with 99mTc. Two labelling methods were used: (1) direct labelling with tin reduction and (2) ligand exchange with tin pyrophosphate. Labelling efficiency and the radiochemical impurities were determined by thin-layer chromatography. Effect of [S...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ercan MT,Tuncel SA,Caner BE,Pişkin E

    更新日期:1993-01-01 00:00:00

  • Preparation of PEG-grafted immunomagnetoliposomes entrapping citrate stabilized magnetite particles and their application in CD34+ cell sorting.

    abstract::Immunomagnetic systems have been used for positive selection of a cell fraction from a mixture using appropriate surface markers with satisfactory results, as haematopoietic CD34+ cells. This work reports on the development of poly(ethylene glycol)-grafted (PEG) immunoliposomes loaded with citrate-magnetite stabilized...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Domingo JC,Mercadal M,Petriz J,De Madariaga MA

    更新日期:2001-01-01 00:00:00

  • Influence of the surface properties of low contact angle surfactants on the body distribution of 14C-poly(methyl methacrylate) nanoparticles.

    abstract::The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Tröster SD,Kreuter J

    更新日期:1992-01-01 00:00:00

  • Production of monodisperse silica gel microspheres for bioencapsulation by extrusion into an oil cross-flow.

    abstract::Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Benson JJ,Wackett LP,Aksan A

    更新日期:2016-08-01 00:00:00

  • Development of a new cyclosporine formulation based on poly(caprolactone) microspheres.

    abstract::The present study describes the development of a new cyclosporine formulation based on polycaprolactone (PCL) microspheres (MS) prepared by the solvent evaporation method. Ternary phase diagrams were used to identify the domains where MS were formed. The application of central composite designs established the influen...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Aberturas MR,Molpeceres J,Guzmán M,García F

    更新日期:2002-01-01 00:00:00

  • Some factors affecting the size of nylon 6-10 microcapsules prepared by interfacial polymerization in a high-voltage electric field.

    abstract::The effect of process variables such as nozzle size, flow-rate of dispersed phase, inter-electrode distance, and presence of an acid acceptor and a thickening agent in the dispersed phase, on the production and size distribution of nylon 6-10 microcapsules prepared by interfacial polymerization in a high-voltage elect...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Etuk BR,Weatherley LR,Murray KR

    更新日期:1995-03-01 00:00:00

  • Microencapsulated electric ink using gelatin/gum arabic.

    abstract::Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Wang DW,Zhao XP

    更新日期:2009-02-01 00:00:00

  • Characterization and in vitro degradation of salicylate-derived poly(anhydride-ester microspheres).

    abstract::The aim of this study was to investigate how glass transition temperature (Tg) influenced polymer microsphere formation and degradation of three chemically, similar novel salicylatebased poly(anhydride-esters): poly[1,6-bis(o-carboxyphenoxy)hexanoate] (CPH), Tg = 59 degrees C; poly[1,8-bis(o-carboxyphenoxy)octanoate] ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yeagy BA,Prudencio A,Schmeltzer RC,Uhrich KE,Cook TJ

    更新日期:2006-09-01 00:00:00

  • Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method.

    abstract::Eudragit RS microspheres containing verapamil HCl for oral use were prepared using three different dispersing agents: aluminium tristearate, magnesium stearate and sucrose stearate, by a solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentra...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Horoz BB,Kiliçarslan M,Yüksel N,Baykara T

    更新日期:2004-03-01 00:00:00

  • Microencapsulation of allopurinol by solvent evaporation and controlled release investigation of drugs.

    abstract::The microencapsulation of drugs is gaining importance in many research activities. A common technique for preparing microcapsules is the solvent evaporation method which is simple but has a large number of reaction control parameters. This study reports the microcapsulation of allopurinol by the solvent evaporation me...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Arabi H,Hashemi SA,Fooladi M

    更新日期:1996-09-01 00:00:00

  • Phagocytosis and degradation of human serum albumin microspheres and nanoparticles in human macrophages.

    abstract::Nanoparticles and microspheres made from human serum albumin are biodegradable and, as a physiological material, less cytocidal than cyanoacrylates. Therefore, they should be a suitable carrier system for targeting drugs into cells of the mononuclear phagocyte system. Nevertheless, the process of phagocytic uptake and...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Schäfer V,von Briesen H,Rübsamen-Waigmann H,Steffan AM,Royer C,Kreuter J

    更新日期:1994-05-01 00:00:00

  • Isotretinoin and α-tocopherol acetate-loaded solid lipid nanoparticle topical gel for the treatment of acne.

    abstract:AIMS:This study was aimed to develop Isotretinoin (ITN) and α-tocopherol acetate (α-TA) loaded solid lipid nanoparticle topical gel for better skin sensitivity and potentiation of efficacy. METHODS:ITN and α-TA-loaded solid lipid nanoparticles (AE-SLN) were prepared by microemulsion method with glyceryl mono-stearate ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gupta S,Wairkar S,Bhatt LK

    更新日期:2020-12-01 00:00:00

  • Chitosan-xanthan gum microparticle-based oral tablet for colon-targeted and sustained delivery of quercetin.

    abstract:CONTEXT:Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered. OBJECTIVES:To prepare chitosan/xanthan gum microparticles to increase QUE oral bioavailability and optimize its release in the colon. MATERIALS AND METHODS:Chitosan/xanthan gum hydrogel embe...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Caddeo C,Nácher A,Díez-Sales O,Merino-Sanjuán M,Fadda AM,Manconi M

    更新日期:2014-01-01 00:00:00

  • Controlling the size of alginate gel beads by use of a high electrostatic potential.

    abstract::The effect of several parameters on the size of alginate beads produced by use of an electrostatic potential bead generator was examined. Parameters studied included needle diameter, electrostatic potential, alginate solution flow rate, gelling ion concentration and alginate concentration and viscosity, as well as alg...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Klokk TI,Melvik JE

    更新日期:2002-07-01 00:00:00

  • Ion-exchange albumin microcapsules of doxorubicin: an in vitro release kinetic evaluation.

    abstract::Cross-linked albumin microcapsules were prepared, using a polycondensation interfacial process. Doxorubicin was incorporated in these microcapsules by simple adsorption from aqueous solution. Increasing the extent of cross-linkage of the microcapsule walls by either increasing the cross-linking agent concentration or ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Sawaya A,Fickat R,Benoit JP,Puisieux F,Benita S

    更新日期:1988-07-01 00:00:00

  • Effect of surface active agents on drug release from polylactic acid-hydrocortisone microcapsules.

    abstract::Polylactic acid microcapsules containing randomly distributed hydrocortisone particles were prepared. The rate of release of hydrocortisone from the microcapsules in pH 7.4 phosphate buffer was found to be largely increased by the presence of polysorbate 80, cetylpyridinium chloride, or aerosol OT in the dissolution m...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Leelarasamee N,Howard SA,Ma JK

    更新日期:1988-01-01 00:00:00