Abstract：
:Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs, optimized formula was 1% w/v polyvinyl alcohol, 1:10 ratio of oil to aqueous and sonicated at 2 and 5 min time for primary and secondary emulsion, respectively. Optimized responses for encapsulation efficiency, particle size and polydispersity index were found to be 39.12 ± 0.01%, 2.06 ± 0.017 µm and 0.95 ± 0.009, respectively, which matched values predicted by mathematical models. About 44.4% of the encapsulated alpha-mangostin was released over 4 weeks. Thermal analysis of the microspheres showed physical conversion of alpha-mangostin from crystallinity to amorphous with encapsulated one had lower in vitro cytotoxicity than free alpha-mangostin. Aerodynamic diameter (784.3 ± 7.5 nm) of this alpha-mangostin microsphere suggests suitability for peripheral pulmonary delivery.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Elsaid Ali AA,Taher M,Mohamed Fdoi
10.3109/02652048.2013.788081subject
Has Abstractpub_date
2013-01-01 00:00:00pages
728-40issue
8eissn
0265-2048issn
1464-5246journal_volume
30pub_type
杂志文章abstract：:Sequential interpenetrating networks of poly(methacrylic acid) and poly(vinyl alcohol) have been prepared and cross-linked with glutaraldehyde to obtain pH sensitive microspheres by a water-in-oil emulsification method. Microspheres have been used to deliver the chosen model anti-inflammatory drug viz., ibuprofen to t...
journal_title：Journal of microencapsulation
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doi：10.1080/02652040801896435
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abstract：CONTEXT:Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. OBJECTIVE:To prepare and characterise tamoxifen (TAM)-loaded SLNs. MATERIALS AND METHODS:Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), tra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.898707
更新日期：2014-01-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.3109/02652049509051129
更新日期：1995-01-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.3109/02652048.2012.680511
更新日期：2012-01-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049509087248
更新日期：1995-07-01 00:00:00
abstract：:Acidic and basic nonsteroidal anti-inflammatory drugs were encapsulated with cellulose derivatives having different functional groups, acidic (carboxymethyl cellulose), basic (chitosan), and neutral (hydroxypropylmethyl cellulose). The properties of the microcapsules were studied and the interaction of the drugs with ...
journal_title：Journal of microencapsulation
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doi：10.3109/02652048909019916
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abstract：:Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the str...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1515998
更新日期：2018-09-01 00:00:00
abstract：:Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802049638
更新日期：2008-12-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.3109/02652049009028419
更新日期：1990-01-01 00:00:00
abstract：:An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.651493
更新日期：2012-01-01 00:00:00
abstract：:A kind of electronic ink, which is supported on indium-tin-oxide (ITO) glass before polymerization, is prepared using urea and formaldehyde resin as wall materials, in which TiO(2) modified with PMMA are dispersed in tetrachloroethylene (TCE) using a mixture of oil blue dyes and charge control additive (span80). Rotar...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040600788197
更新日期：2006-11-01 00:00:00
abstract：:Isoniazid was encapsulated into microspheres of alginate-chitosan by means of a complex coacervation method in an emulsion system. Since the encapsulation of isoniazid tends to be limited by its hydrophilic characteristics, this study proposes its microencapsulation by adsorption. The particles were prepared in three ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:Microencapsulation is almost exclusively performed in batch processes. With today's chemistry increasingly performed in flow reactors, this work aims to realise a continuous reactor setup for the encapsulation of an ester with a polyuria (PU) shell. The generation of an emulsion template is performed in a recirculatio...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1633433
更新日期：2019-06-01 00:00:00
abstract：:This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.651503
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...
journal_title：Journal of microencapsulation
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更新日期：2012-01-01 00:00:00
abstract：:Aims: The study was carried out to synthesise and characterise the chitosan-encapsulated genistein (CHI-En/Gen) and determine its anti-cancer and anti-angiogenic properties.Methods: The cytotoxic and anti-angiogenic activity of CHI-En/Gen was performed using MTT and chorioallantoic membrane assay. The molecular action...
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Journal of microencapsulation
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doi：10.3109/02652048.2014.973072
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doi：10.1080/02652040110065413
更新日期：2002-03-01 00:00:00
abstract：:Enteric diastase spherules were prepared using cellulose acetate phthalate and eudragit RS-100 by emulsion solvent removal method. Factors that could affect the size shape and diastatic activity were studied. The studied factors include pH of aqueous media, temperature of dispersion media and concentration of surface ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049109021868
更新日期：1991-10-01 00:00:00
abstract：:Polylactide (PLA) and polylactide-co-glycolide (PLGA) particles entrapping rotavirus (strain SA11) were formulated using a solvent evaporation technique. To minimize denaturation of viral antigen during the emulsification process, serum albumin was used as a stabilizer. Use of NaHCO(3) and sucrose during the primary e...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802211709
更新日期：2009-03-01 00:00:00
abstract：:Poly-D,L-lactide (PDLLA) and polylactide-co-glycolide (PLGA) microspheres containing thymopentin have been prepared by a water-in-oil-in-water-emulsion/solvent evaporation technique. The goal is to stabilize the active compound thymopentin, and to prolong its therapeutic activity, by embedding the drug in a polymeric ...
journal_title：Journal of microencapsulation
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更新日期：1997-05-01 00:00:00
abstract：:Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and micr...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048909098018
更新日期：1989-04-01 00:00:00
abstract：:A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulate...
journal_title：Journal of microencapsulation
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更新日期：2004-11-01 00:00:00
abstract：:Microspheres, including microcapsules and cells or beads, are widely used to produce many functional products. Information about their mechanical properties is essential to understanding their performance during manufacturing, processing and end-use applications. The mechanical characterization of microspheres require...
journal_title：Journal of microencapsulation
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更新日期：2012-01-01 00:00:00
abstract：:Immunomagnetic systems have been used for positive selection of a cell fraction from a mixture using appropriate surface markers with satisfactory results, as haematopoietic CD34+ cells. This work reports on the development of poly(ethylene glycol)-grafted (PEG) immunoliposomes loaded with citrate-magnetite stabilized...
journal_title：Journal of microencapsulation
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更新日期：2001-01-01 00:00:00
abstract：:The formation of microcapsules which contain rosemary oil, is herewith described. The process is based on two steps: (a) formation of oil-in-water emulsions, by using lecithin as emulsifier, thus imparting negative charges on the oil droplets; (b) addition of a cationic biopolymer, chitosan, in conditions that favor t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049709015332
更新日期：1997-03-01 00:00:00
abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...
journal_title：Journal of microencapsulation
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更新日期：2003-07-01 00:00:00
