Abstract:
AIM:To develop a biocompatible cobalt ferrite (CF-NP) nanodrug formulation using oleic acid and poly (d,l-lactide-co-glycolic) acid (PLGA) for the delivery of docetaxel (DTX) specifically to breast cancer cells. METHODS:The CF-NP were synthesised by hydrothermal method and conjugated with DTX in a PLGA matrix and were systematically characterised using XRD, FE-SEM, TEM, DLS, FTIR, TGA, SQUID etc. The drug loading, in vitro drug release, cellular uptake, cytotoxicity were evaluated and haemolytic effect was studied. RESULTS:The CF-NP showed good crystallinity with an average particle size of 21 nm and ferromagnetic nature. The DTX-loaded CF-NP (DCF-NP) showed 8.4% (w/w) drug loading with 81.8% loading efficiency with a sustained DTX release over time. An effective internalisation and anti-proliferative efficiency was observed in MCF-7 and MDA-MB-231 breast cancer cells and negligible haemolytic effect. CONCLUSION:The DCF-NP can have the potential for the effective delivery of DTX for breast cancer treatment.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Panda J,Satapathy BS,Mandal B,Sen R,Mukherjee B,Sarkar R,Tudu Bdoi
10.1080/02652048.2020.1842529subject
Has Abstractpub_date
2021-01-01 00:00:00pages
36-46issue
1eissn
0265-2048issn
1464-5246journal_volume
38pub_type
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