Self-assembled micelles based on gambogenic acid-phospholipid complex for sustained-release drug delivery.

Abstract:

:Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size of the GNA-PLC micelles was 291.23 nm which was approximate agreed with the transmission electron microscopy (TEM). In vitro release profile showed the GNA-PLC and GNA-PLC micelles have significant sustained-release of GNA compared with crude GNA. Pharmacokinetic parameters indicated that the area under concentration-time curve (AUC0→t) of GNA in cases of GNA-PLC and GNA-PLC micelles are 2.04- and 3.92-fold higher than crude GNA, respectively. Conclusions: The better water solubility and higher bioavailability of GNA in GNA-PLC micelles with significant sustained-release of GNA endow the nanoparticle with great potential in GNA delivery system.

journal_name

J Microencapsul

authors

Wang B,Cheng W,Zhang C,Bao Y,Zha L,Qian J,Hong L,Chen W

doi

10.1080/02652048.2019.1656294

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

566-575

issue

6

eissn

0265-2048

issn

1464-5246

journal_volume

36

pub_type

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