Abstract:
:In this study, we formulated a microparticulate melanoma cancer vaccine via the transdermal route. The vaccine was delivered using microneedle-based Dermaroller® which is available for cosmetic purposes. Unlike subcutaneous injections, administration using microneedles is painless and in general can increase the permeability of many compounds ranging in size from small molecules to proteins and microparticles that do not normally penetrate the skin. The vaccine microparticles were taken up by the antigen presenting cells which demonstrated a strong IgG titre level of 930 ug/mL in serum samples. The formulation increased the immunogenicity of the vaccine by incorporating the antigen into an albumin matrix having a size range of around 0.63-1.4 µm which acted as a synthetic adjuvant. The animals were vaccinated with 1 prime and 4 booster doses administered every 14 days over 8 weeks duration, followed by challenge with live tumour cells which showed protection after transdermal vaccination.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Bhowmik T,D'Souza B,Shashidharamurthy R,Oettinger C,Selvaraj P,D'Souza MJdoi
10.3109/02652048.2011.559287subject
Has Abstractpub_date
2011-01-01 00:00:00pages
294-300issue
4eissn
0265-2048issn
1464-5246journal_volume
28pub_type
杂志文章abstract::Polyelectrolyte complexes (PEC) provide new opportunities for controlled release system of drugs, and have potentials to address challenges on the way to effective oral insulin delivery. Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two opposit...
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journal_title:Journal of microencapsulation
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