Impact of microparticle formulation approaches on drug burst release: a level A IVIVC.

Abstract:

AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were compared; the in situ forming microparticle (ISM) and the emulsion-solvent evaporation (ESE) methods using an experimental design. The MPs obtained were compared according to their physical characterization, burst release and T80%. An in vivo pharmacokinetic study with in vitro-in vivo correlation (IVIVC) was also performed for the selected formula. RESULTS:Both methods were able to sustain drug release for three weeks. ISM produced more porous particles and was not effective as ESE for controlling burst release. A good IVIVC (R(2) = 0.9755) was attained when injecting the selected formula into rats. CONCLUSION:MPs prepared with ESE showed a minimum burst release and a level A IVIVC was obtained when administered to rats.

journal_name

J Microencapsul

authors

Ishak RA,Mortada ND,Zaki NM,El-Shamy Ael-H,Awad GA

doi

10.3109/02652048.2014.913724

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

674-84

issue

7

eissn

0265-2048

issn

1464-5246

journal_volume

31

pub_type

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