Functionality of protective colloids affecting the formation, size uniformity and morphology of drug-free polylactic acid microspheres.

Abstract:

:Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on the formation, size uniformity and morphology of PLA microspheres was investigated. Four characteristic functions (surface activity, viscosity, electric charge and interfacial film formation) of the hydrophilic polymer aqueous solutions were used to evaluate the efficacy of these protective colloids used. The results indicate that these four functions were the key parameters to achieve the formation of PLA microspheres. The best protective colloid should have high surface activity, optimum viscosity, adequate electric charge, and form an interfacial film to give a higher recovery, better size uniformity and smoother topography of the PLA microspheres.

journal_name

J Microencapsul

authors

Lin SY,Chen KS,Teng HH

doi

10.3109/02652049809006865

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

383-90

issue

3

eissn

0265-2048

issn

1464-5246

journal_volume

15

pub_type

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