Abstract:
:The primary objective was to synthesize a novel wound dressing containing basic fibroblast growth factor (bFGF)-loaded microspheres for promoting healing and tissue regeneration. Gelatin sponge was chosen as the underlying layer and elastomeric polyurethane membranes were used as the external layer. To achieve prolonged release, bFGF addition was loaded in microspheres. The microspheres were characterized for particle size, in vitro protein release and bioactivity. The bilayer dressings were tested in in vivo experiments on full-thickness skin defects created on pigs. Average size of the microspheres was 14.36 +/- 3.56 microm and the network sponges were characterized with an average pore size of 80-160 microm. Both the in vitro release efficiency and the protein bioactivity revealed that bFGF was released in a controlled manner and it was biologically active as assessed by its ability to induce the proliferation of fibroblasts. It was observed that sustained release of bFGF provided a higher degree of reduction in the wound areas. Histological investigations showed that the dressings were biocompatible and did not cause any mononuclear cell infiltration or foreign body reaction. The structure of the newly formed dermis was almost the same as that of the normal skin. The application of these novel bilayer wound dressings provided an optimum healing milieu for the proliferating cells and regenerating tissues in pig's skin defect models.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Huang S,Deng T,Wu H,Chen F,Jin Ydoi
10.1080/02652040500435170subject
Has Abstractpub_date
2006-05-01 00:00:00pages
277-90issue
3eissn
0265-2048issn
1464-5246pii
H98751275L803635journal_volume
23pub_type
杂志文章abstract::Documented to exhibit cytotoxicity and poor oral bioavailability, alpha-mangostin was encapsulated into PLGA microspheres with optimization of formulation using response surface methodology. Mixed levels of four factors Face central composite design was employed to evaluate critical formulation variables. With 30 runs...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2013.788081
更新日期:2013-01-01 00:00:00
abstract::Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1178352
更新日期:2016-06-01 00:00:00
abstract::Regular spherical microspheres of 220-260 microns average size have been prepared from vinylpyrrolidone/vinylacetate copolymer using a solvent evaporation method. Griseofulvin has been incorporated into these microspheres and its physical characterization has been carried out by differential scanning calorimetry (DSC)...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049309015315
更新日期:1993-01-01 00:00:00
abstract::This study explored a liquid phase coating technique to produce polymethyl methacrylate (PMMA)-coated alginate microspheres. Alginate microspheres with a mean diameter of 85.6 microm were prepared using an emulsification method. The alginate microspheres, as cores, were then coated with different types of PMMA by a li...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040500273936
更新日期:2005-12-01 00:00:00
abstract::This work demonstrates Box-Behnken design (BBD)'s capability in exploring scientific principles governing a process, different from its use in process optimisation. We have investigated nanoprecipitation (NP) of temozolomide with polycaprolactone. Five factors, surfactant, stirring speed (SS), dropping rate (DR), phas...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.950710
更新日期:2015-01-01 00:00:00
abstract::Enteric diastase spherules were prepared using cellulose acetate phthalate and eudragit RS-100 by emulsion solvent removal method. Factors that could affect the size shape and diastatic activity were studied. The studied factors include pH of aqueous media, temperature of dispersion media and concentration of surface ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109021868
更新日期:1991-10-01 00:00:00
abstract::A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...
journal_title:Journal of microencapsulation
pub_type: 杂志文章,评审
doi:10.3109/02652049809006844
更新日期:1998-03-01 00:00:00
abstract::Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morp...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2016.1144817
更新日期:2016-01-01 00:00:00
abstract::Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009028424
更新日期:1990-01-01 00:00:00
abstract::In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040400008515
更新日期:2004-12-01 00:00:00
abstract::In this study, recombinant human interleukin-2 (rhIL-2) containing poly(lactic-co-glycolic acid) (PLGA) microparticles were prepared for pulmonary administration by modified w/o/w double emulsion solvent extraction method and the effects of various formulation parameters on the physicochemical properties of the microp...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.599438
更新日期:2011-01-01 00:00:00
abstract::Aims: The study was carried out to synthesise and characterise the chitosan-encapsulated genistein (CHI-En/Gen) and determine its anti-cancer and anti-angiogenic properties.Methods: The cytotoxic and anti-angiogenic activity of CHI-En/Gen was performed using MTT and chorioallantoic membrane assay. The molecular action...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1740804
更新日期:2020-06-01 00:00:00
abstract::Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040802127806
更新日期:2009-02-01 00:00:00
abstract::Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049709033835
更新日期:1997-07-01 00:00:00
abstract:CONTEXT:Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. OBJECTIVE:To prepare and characterise tamoxifen (TAM)-loaded SLNs. MATERIALS AND METHODS:Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), tra...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.898707
更新日期:2014-01-01 00:00:00
abstract::Microencapsulation is almost exclusively performed in batch processes. With today's chemistry increasingly performed in flow reactors, this work aims to realise a continuous reactor setup for the encapsulation of an ester with a polyuria (PU) shell. The generation of an emulsion template is performed in a recirculatio...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1633433
更新日期:2019-06-01 00:00:00
abstract::Polyelectrolyte complexes (PEC) provide new opportunities for controlled release system of drugs, and have potentials to address challenges on the way to effective oral insulin delivery. Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two opposit...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1604846
更新日期:2019-01-01 00:00:00
abstract::Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2010.489973
更新日期:2010-01-01 00:00:00
abstract::Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049409040434
更新日期:1994-01-01 00:00:00
abstract::In this study, ethylcellulose and acrylate-methacrylate copolymer (Eudragit RL 100, Eudragit RS 100) membranes were prepared by using appropriate types and amounts of plasticizers. Thirty percent and 20% of triacetin based on polymer weight were found to be appropriate plasticizers for ethylcellulose membranes and acr...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049609026048
更新日期:1996-11-01 00:00:00
abstract::The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined. The following systems were used: Ca-alginate granules (AG) prepared by various methods, porous carbonate cores with mu...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1206146
更新日期:2016-08-01 00:00:00
abstract:AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were com...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.913724
更新日期:2014-01-01 00:00:00
abstract::Indomethacin-loaded dietheylaminoethyl trisacryl microspheres (DEAE-MS), originally designed for therapeutic embolization, were encapsulated using two methods: coacervation and solvent evaporation/extraction. This encapsulation was achieved using a biocompatible polymer, the PLGA 50 : 50, and aimed to control the rele...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701843388
更新日期:2008-03-01 00:00:00
abstract::Atomic force microscopy (AFM) is recognized a suitable and powerful technique for surface and morphological analysis. Even if until now this technique has not been frequently used in the pharmaceutical field, it can contribute to an accurate morphologic characterization of microspheres and nanospheres. In this work, a...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040500435220
更新日期:2006-03-01 00:00:00
abstract::The body distribution of surfactant-coated and non-coated poly(methyl methacrylate) nanoparticles with a size of 131 +/- 30 nm after intravenous injection into rats was investigated. The coating materials were poloxamine 904, poloxamine 908, poloxamine 1508, poloxamer 338, and Brij 35. These materials were preselected...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049209021219
更新日期:1992-01-01 00:00:00
abstract::Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved unifo...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040601035143
更新日期:2006-12-01 00:00:00
abstract::Liposomes were introduced first in 1980 for topical drug delivery and since then have attracted considerable interest and generated many speculative claims concerning their potential utility both as a drug carrier and reservoir for controlled release of drugs within various layers of the skin. A number of clinical stu...
journal_title:Journal of microencapsulation
pub_type: 杂志文章,评审
doi:10.3109/02652049309104381
更新日期:1993-04-01 00:00:00
abstract::This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.651503
更新日期:2012-01-01 00:00:00
abstract::An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.651493
更新日期:2012-01-01 00:00:00
abstract::We demonstrate the microencapsulation of a double-base (DB) rocket propellant stabiliser, 2-nitrodiphenylamine (2-NDPA), that can potentially increase the shelf life of DB rocket propellants. Poly(lactide-co-glycolide) (PLG) microspheres loaded with 2-NDPA were prepared using the oil-in-water emulsion technique. The m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2012.668956
更新日期:2012-01-01 00:00:00