Preparation of sub-100-nm beta-lactoglobulin (BLG) nanoparticles.

Abstract:

:Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved uniformity. Bovine serum albumin (BSA) nanoparticles, prepared under similar conditions for comparison, were larger and less uniform. The half-width of 80% particle distribution was used to compare the uniformity of particle size distribution. The stability of the nanoparticles was investigated by degradation tests at neutral and acidic pHs with and without proteolytic enzymes, trypsin and pepsin. The degradation time, determined by a graphical approach, was used to compare the relative stabilities of BLG and BSA nanoparticles. The particles of BLG were more stable than those of BSA in acidic and neutral media with and without added enzymes.

journal_name

J Microencapsul

authors

Ko S,Gunasekaran S

doi

10.1080/02652040601035143

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

887-98

issue

8

eissn

0265-2048

issn

1464-5246

journal_volume

23

pub_type

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