Abstract:
:Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved uniformity. Bovine serum albumin (BSA) nanoparticles, prepared under similar conditions for comparison, were larger and less uniform. The half-width of 80% particle distribution was used to compare the uniformity of particle size distribution. The stability of the nanoparticles was investigated by degradation tests at neutral and acidic pHs with and without proteolytic enzymes, trypsin and pepsin. The degradation time, determined by a graphical approach, was used to compare the relative stabilities of BLG and BSA nanoparticles. The particles of BLG were more stable than those of BSA in acidic and neutral media with and without added enzymes.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Ko S,Gunasekaran Sdoi
10.1080/02652040601035143subject
Has Abstractpub_date
2006-12-01 00:00:00pages
887-98issue
8eissn
0265-2048issn
1464-5246journal_volume
23pub_type
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