Preparation and study of release kinetics of rosin pentaerythritol ester microcapsules.

Abstract:

:Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release characteristics in simulated gastric and intestinal fluids. The microcapsule size increased as the acid value of the ester decreased. The release of the drug was studied by using first-order, Higuchi and Hixon-Crowell cube root models. The release mechanism of the microcapsules is discussed.

journal_name

J Microencapsul

authors

Sheorey DS,Dorle AK

doi

10.3109/02652049409040434

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

11-7

issue

1

eissn

0265-2048

issn

1464-5246

journal_volume

11

pub_type

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