Abstract:
CONTEXT:Flavonoids show promising anticancer potential but it is limited due to poor solubility. OBJECTIVE:The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line. METHODS:The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Storage stability of Ch-PC-SLNs was evaluated up to 3 months. Solid state properties (DSC, XRD) and morphology (AFM) of Ch-PC-SLNs were also studied. In-vitro anticancer activity was investigated by using MTT assay. RESULTS AND DISCUSSION:Ch-PC-SLNs exhibited higher encapsulation efficiency than Ch-SLNs and zero order release kinetics. Ch-PC-SLNs were found to be stable upto 3 months upon lyophilisation with mannitol as cryoprotectant. DSC and XRD study revealed the loss of highly crystalline nature of Chrysin in Ch-PC-SLNs. The Ch-PC-SLNs lead to significantly higher in-vitro anticancer activity than that of bulk Chrysin. CONCLUSION:The study concludes that phospholipids complex with Chrysin lead to improve encapsulation, storage stability of SLNs and in vitro anticancer activity.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Komath S,Garg A,Wahajuddin Mdoi
10.1080/02652048.2018.1559369subject
Has Abstractpub_date
2018-09-01 00:00:00pages
600-617issue
6eissn
0265-2048issn
1464-5246journal_volume
35pub_type
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