Development and evaluation of Chrysin-Phospholipid complex loaded solid lipid nanoparticles - storage stability and in vitro anti-cancer activity.


CONTEXT:Flavonoids show promising anticancer potential but it is limited due to poor solubility. OBJECTIVE:The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluated for potential increase in the anti-cancer activity against MCF-7 cell line. METHODS:The physiochemical characteristics and release kinetics for Ch-SLNs and Ch-PC-SLNs were evaluated and compared. Storage stability of Ch-PC-SLNs was evaluated up to 3 months. Solid state properties (DSC, XRD) and morphology (AFM) of Ch-PC-SLNs were also studied. In-vitro anticancer activity was investigated by using MTT assay. RESULTS AND DISCUSSION:Ch-PC-SLNs exhibited higher encapsulation efficiency than Ch-SLNs and zero order release kinetics. Ch-PC-SLNs were found to be stable upto 3 months upon lyophilisation with mannitol as cryoprotectant. DSC and XRD study revealed the loss of highly crystalline nature of Chrysin in Ch-PC-SLNs. The Ch-PC-SLNs lead to significantly higher in-vitro anticancer activity than that of bulk Chrysin. CONCLUSION:The study concludes that phospholipids complex with Chrysin lead to improve encapsulation, storage stability of SLNs and in vitro anticancer activity.


J Microencapsul


Komath S,Garg A,Wahajuddin M




Has Abstract


2018-09-01 00:00:00












  • Liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.): characterization of aqueous dispersions and lyophilized formulations.

    abstract::Multilamellar liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.) leaves were produced by dry film hydration. Gas chromatography demonstrated the compounds found in the essential oil were effectively incorporated in the aqueous dispersions of liposomes. Differential scanning calorimetry ana...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yoshida PA,Yokota D,Foglio MA,Rodrigues RA,Pinho SC

    更新日期:2010-01-01 00:00:00

  • Preparation and characterization of textile-based carrier systems for anal fissure treatment.

    abstract::Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement,...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Sarıışık AM,Karavana SY,Türkoğlu GC,Rençber S,Önder T

    更新日期:2017-12-01 00:00:00

  • Mechanical characterization of microspheres - capsules, cells and beads: a review.

    abstract::Microspheres, including microcapsules and cells or beads, are widely used to produce many functional products. Information about their mechanical properties is essential to understanding their performance during manufacturing, processing and end-use applications. The mechanical characterization of microspheres require...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章,评审


    authors: Mercadé-Prieto R,Zhang Z

    更新日期:2012-01-01 00:00:00

  • Preparation of PEG-grafted immunomagnetoliposomes entrapping citrate stabilized magnetite particles and their application in CD34+ cell sorting.

    abstract::Immunomagnetic systems have been used for positive selection of a cell fraction from a mixture using appropriate surface markers with satisfactory results, as haematopoietic CD34+ cells. This work reports on the development of poly(ethylene glycol)-grafted (PEG) immunoliposomes loaded with citrate-magnetite stabilized...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Domingo JC,Mercadal M,Petriz J,De Madariaga MA

    更新日期:2001-01-01 00:00:00

  • Preparation of polyurea/melamine formaldehyde double-layered self-healing microcapsules and investigation on core fraction.

    abstract::Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ming Y,Hu J,Xing J,Wu M,Qu J

    更新日期:2016-06-01 00:00:00

  • Optimisation of polymer coating process for microencapsulating ferrous fumarate for salt double fortification with iodine and iron.

    abstract::An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Yadava D,Olive Li Y,Diosady LL,Wesley AS

    更新日期:2012-01-01 00:00:00

  • Preparation of soft microcapsules containing multiple core materials with interfacial dehydration reaction using the (W/O)/W emulsion.

    abstract::The soft microcapsules containing eucalyptus oil, ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the water-in-oil-in-water type multiple (W/O)/W emulsion. The diameters of the microcapsules and the content and the mi...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Taguchi Y,Suzuki T,Saito N,Yokoyama H,Tanaka M

    更新日期:2017-12-01 00:00:00

  • Preparation and in vitro evaluation of thiolated chitosan microparticles.

    abstract::The objective of this study was to prepare a microparticulate drug delivery system being based on a new thiomer, namely a chitosan 2-iminothiolane conjugate (chitosan-TBA conjugate). Due to thiol groups being immobilized on chitosan, chitosan-TBA conjugate exhibits improved mucoadhesive and permeation enhancing proper...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Maculotti K,Genta I,Perugini P,Imam M,Bernkop-Schnürch A,Pavanetto F

    更新日期:2005-08-01 00:00:00

  • Oxprenolol release from bioadhesive gelatin/poly(acrylic acid) microspheres.

    abstract::Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Leucuta SE,Ponchel G,Duchêne D

    更新日期:1997-07-01 00:00:00

  • Ceramic encapsulation with polymer via co-axial electrohydrodynamic jetting.

    abstract::Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Nangrejo M,Ahmad Z,Edirisinghe M

    更新日期:2010-01-01 00:00:00

  • Effective parameters for formulation of gastro adhesive nanoparticles: screening by design-of-experiments approach.

    abstract::The objective of this study was selection of most influential variable for the preparation of gastro adhesive nanoparticles of acyclovir. Effect of formulation and processing variables on various response variables were studied by a Taguchi standard orthogonal array L8 design. Independent variables studied were the am...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Kharia AA,Singhai AK

    更新日期:2014-01-01 00:00:00

  • Wound dressings containing bFGF-impregnated microspheres.

    abstract::The primary objective was to synthesize a novel wound dressing containing basic fibroblast growth factor (bFGF)-loaded microspheres for promoting healing and tissue regeneration. Gelatin sponge was chosen as the underlying layer and elastomeric polyurethane membranes were used as the external layer. To achieve prolong...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Huang S,Deng T,Wu H,Chen F,Jin Y

    更新日期:2006-05-01 00:00:00

  • Surface characterization of oil-containing polyterephthalamide microcapsules prepared by interfacial polymerization.

    abstract::Oil-containing polyterephthalamide microcapsules were synthesized by the interfacial polymerization of an oil-soluble monomer (terephthaloyl dichloride, TDC) and a mixture of two water-soluble monomers (diethylenetriamine, DETA, and 1, 6-hexamethylenediamine, HMDA). The influence of several synthesis parameters (e.g. ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Alexandridou S,Kiparissides C,Mange F,Foissy A

    更新日期:2001-11-01 00:00:00

  • Current progress and future prospects of liposomes in dermal drug delivery.

    abstract::Liposomes were introduced first in 1980 for topical drug delivery and since then have attracted considerable interest and generated many speculative claims concerning their potential utility both as a drug carrier and reservoir for controlled release of drugs within various layers of the skin. A number of clinical stu...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章,评审


    authors: Moghimi SM,Patel HM

    更新日期:1993-04-01 00:00:00

  • Green coffee nanoparticles: optimisation, in vitro bioactivity and bio-release property.

    abstract::Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Desai NM,Gilbert Stanley J,Murthy PS

    更新日期:2020-01-01 00:00:00

  • Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles.

    abstract:AIMS:This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. METHODS:Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and po...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ozturk N,Kara A,Gulyuz S,Ozkose UU,Tasdelen MA,Bozkir A,Yilmaz O,Vural I

    更新日期:2020-11-01 00:00:00

  • Microencapsulation and oxidative stability of spray-dried fish oil emulsions.

    abstract::Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Hogan SA,O'Riordan ED,O'Sullivan M

    更新日期:2003-09-01 00:00:00

  • Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers.

    abstract::Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Wang L,Ma Y,Gu Y,Liu Y,Zhao J,Yan B,Wang Y

    更新日期:2018-05-01 00:00:00

  • Sustained-release dosage form of nitrofurantoin. Part 2. In vivo urinary excretion in man.

    abstract::The in vivo absorption of crystalline nitrofurantoin and the dosage forms of nitrofurantoin prepared with microcapsules were carried out in man by determination of urinary excretion of unchanged nitrofurantoin. The cumulative amount of drug excreted and the duration of the therapeutic urine levels were compared. The m...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ertan G,Karasulu E,Abou-Nada M,Tosun M,Ozer A

    更新日期:1994-03-01 00:00:00

  • Preparation and study of release kinetics of rosin pentaerythritol ester microcapsules.

    abstract::Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Sheorey DS,Dorle AK

    更新日期:1994-01-01 00:00:00

  • Influence of experimental parameters on the microencapsulation of a photopolymerizable phase.

    abstract::Conditions of microencapsulation by in situ polycondensation, using melamine-formaldehyde as wall material, are influenced by the chemical nature of the core to encapsulate. In our study concerning the encapsulation of a photopolymerizable phase containing an electrically charged compound, it was necessary to modify t...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Pernot JM,Brun H,Pouyet B,Sergent M,Phan-Tan-Luu R

    更新日期:1993-07-01 00:00:00

  • Microencapsulation of drugs by the coacervation technique using ethylcellulose and acrylate-methacrylate copolymer as wall materials.

    abstract::In this study, ethylcellulose and acrylate-methacrylate copolymer (Eudragit RL 100, Eudragit RS 100) membranes were prepared by using appropriate types and amounts of plasticizers. Thirty percent and 20% of triacetin based on polymer weight were found to be appropriate plasticizers for ethylcellulose membranes and acr...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Nimmannit U,Suwanpatra N

    更新日期:1996-11-01 00:00:00

  • Investigation of the release of aspirin from spray-congealed micro-pellets.

    abstract::The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied. The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism. Micro-pellets produced were sieved into several fractions and...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Guo QY,Chan LW,Heng PW

    更新日期:2005-05-01 00:00:00

  • Development of a new delivery system consisting in 'drug-in cyclodextrin-in PLGA nanoparticles'.

    abstract::A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Mura P,Maestrelli F,Cecchi M,Bragagni M,Almeida A

    更新日期:2010-01-01 00:00:00

  • Development and characterisation of a novel chitosan-coated antioxidant liposome containing both coenzyme Q10 and alpha-lipoic acid.

    abstract::This article describes the physicochemical properties of chitosan-coated liposomes containing skin-protecting agents, coenzyme Q10 and alpha-lipoic acid (CCAL). CCAL had a spherical shell-core structure and liposomes inverted the surface charge from negative to positive after coating with chitosan. Compared with the u...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Zhao GD,Sun R,Ni SL,Xia Q

    更新日期:2015-01-01 00:00:00

  • Solid lipid nanoparticles and nanosuspension formulation of Saquinavir: preparation, characterization, pharmacokinetics and biodistribution studies.

    abstract::Solid lipid nanoparticles (SLNs) and nanosuspensions (NSs) have shown great promise for improving bioavailability of poorly water-soluble drugs. This study was aimed to develop SLNs and NS of Saquinavir (SQ) for improvement in bioavailability. These formulations were characterized and their pharmacokinetics and biodis...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Dodiya SS,Chavhan SS,Sawant KK,Korde AG

    更新日期:2011-01-01 00:00:00

  • Formulation and evaluation of vinylpyrrolidone/vinylacetate copolymer microspheres with griseofulvin.

    abstract::Regular spherical microspheres of 220-260 microns average size have been prepared from vinylpyrrolidone/vinylacetate copolymer using a solvent evaporation method. Griseofulvin has been incorporated into these microspheres and its physical characterization has been carried out by differential scanning calorimetry (DSC)...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Vojnovic D,Rubessa F,Bogataj M,Mrhar A

    更新日期:1993-01-01 00:00:00

  • Hyaluronidase-injectable microparticles intended for the treatment of extravasation.

    abstract::Hyaluronidase is a protein whose enzymatic activity is successfully employed in extravasation therapy. Taking into account that several proteins (e.g. gelatin and albumin) have been employed as natural polymers for the preparation of microspheres, this work approaches a comprehensive investigation on hyaluronidase inj...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Modena T,Conti B,Genta I,Pauanetto F,Tira ME,Sini P,Gazzaniga A

    更新日期:1998-01-01 00:00:00

  • Liquid phase coating to produce controlled-release alginate microspheres.

    abstract::This study explored a liquid phase coating technique to produce polymethyl methacrylate (PMMA)-coated alginate microspheres. Alginate microspheres with a mean diameter of 85.6 microm were prepared using an emulsification method. The alginate microspheres, as cores, were then coated with different types of PMMA by a li...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Chan LW,Liu X,Heng PW

    更新日期:2005-12-01 00:00:00

  • Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea.

    abstract::In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: De TK,Bergey EJ,Chung SJ,Rodman DJ,Bharali DJ,Prasad PN

    更新日期:2004-12-01 00:00:00