Microspheres with pH modulated release: design and characterization of formulation variables for colonic delivery.

abstract：:The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined. The following systems were used: Ca-alginate granules (AG) prepared by various methods, porous carbonate cores with mu...

journal_title：Journal of microencapsulation

authors： Sudareva N,Suvorova O,Saprykina N,Vilesov A,Bel'tyukov P,Petunov S

更新日期：2016-08-01 00:00:00

abstract：:Monodisperse albumin microspheres were successfully prepared by both chemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersity of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier c...

journal_title：Journal of microencapsulation

authors： el-Mahdy M,Ibrahim ES,Safwat S,el-Sayed A,Ohshima H,Makino K,Muramatsu N,Kondo T

更新日期：1998-09-01 00:00:00

abstract：:Artificial chylomicron remnants were investigated as a new drug carrier system for the targeting of hepatic parenchymal cells. The emulsions presented here are similar in particle size and composition to natural lipoproteins. The preparations contained triolein, phospholipid, cholesterol and cholesteryl oleate. Egg yo...

journal_title：Journal of microencapsulation

authors： Vuaridel-Bonanomi ES,Weder HG

更新日期：1991-04-01 00:00:00

abstract：:Polyisohexylcyanoacrylate nanocapsules containing cyclosporin were prepared by mixing in a 1:2 ratio an oil/ethanol solution of monomer and drug with an aqueous phase. Drug nanoencapsulation rate was controlled by its partition coefficient between the inner (organic) and outer (aqueous) phases. Thus highest encapsulat...

journal_title：Journal of microencapsulation

authors： Bonduelle S,Foucher C,Leroux JC,Chouinard F,Cadieux C,Lenaerts V

更新日期：1992-04-01 00:00:00

abstract：:Indomethacin micro-crystals sized approximately 2 microm have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on approximately 2 microm drug micro-c...

journal_title：Journal of microencapsulation

authors： Chen Y,Lin X

更新日期：2005-02-01 00:00:00

abstract：:We demonstrate the microencapsulation of a double-base (DB) rocket propellant stabiliser, 2-nitrodiphenylamine (2-NDPA), that can potentially increase the shelf life of DB rocket propellants. Poly(lactide-co-glycolide) (PLG) microspheres loaded with 2-NDPA were prepared using the oil-in-water emulsion technique. The m...

journal_title：Journal of microencapsulation

authors： Shorty M,Singh S,Jebrail FF,Andrews MJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Naproxen CR tablets have been obtained from its microspheres prepared by coprecipitation with Eudragit L100-55. The purpose of this work was to evaluate the main and interaction effects of deaggregating agent concentration (X1), compression pressure (X2) and amount of precipitating water (X3) on naproxen releas...

journal_title：Journal of microencapsulation

authors： Zaghloul AA,Vaithiyalingam SR,Faltinek J,Reddy IK,Khan MA

更新日期：2001-09-01 00:00:00

abstract：:In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...

journal_title：Journal of microencapsulation

authors： De TK,Bergey EJ,Chung SJ,Rodman DJ,Bharali DJ,Prasad PN

更新日期：2004-12-01 00:00:00

abstract：:Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved unifo...

journal_title：Journal of microencapsulation

authors： Ko S,Gunasekaran S

更新日期：2006-12-01 00:00:00

abstract：:Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...

journal_title：Journal of microencapsulation

authors： Wang DW,Zhao XP

更新日期：2009-02-01 00:00:00

abstract：:Transplantation of cells genetically modified to produce neurotrophins is a promising spinal cord repair strategy. Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF. We here compared...

journal_title：Journal of microencapsulation

authors： Francis NL,Shanbhag MS,Fischer I,Wheatley MA

更新日期：2011-01-01 00:00:00

abstract：:Liposomes were introduced first in 1980 for topical drug delivery and since then have attracted considerable interest and generated many speculative claims concerning their potential utility both as a drug carrier and reservoir for controlled release of drugs within various layers of the skin. A number of clinical stu...

journal_title：Journal of microencapsulation

authors： Moghimi SM,Patel HM

更新日期：1993-04-01 00:00:00

abstract：:The aim of this work was to investigate the role of HLB of emulsifier as well as volume of the internal aqueous phase (W(1)) and presence of salt in the external aqueous phase (W(2)) on the morphology, size and encapsulation efficiency of poly(D,L-lactide) microspheres containing naltrexone HCl. PLA microparticles con...

journal_title：Journal of microencapsulation

authors： Dinarvand R,Moghadam SH,Sheikhi A,Atyabi F

更新日期：2005-03-01 00:00:00

abstract：:Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...

journal_title：Journal of microencapsulation

authors： Goto S,Kawata M,Nakamura M,Maekawa K,Aoyama T

更新日期：1986-10-01 00:00:00

abstract：:The present study is part of a larger project whose aim is to understand how the oyster Crassostrea gigas develops its aromas from a lipid precursor, the eicosapentaenoic acid (EPA), in glyceride form. The objective of this study is, therefore, to prepare an encapsulation process that will enable the bivalve to be sup...

journal_title：Journal of microencapsulation

authors： Jouzel B,Pennarun AL,Prost C,Renard D,Poncelet D,Demaimay D

更新日期：2003-01-01 00:00:00

abstract：:The factors influencing the encapsulation of azathioprine (AZA) into liposomes were investigated to find out the conditions for its optimal entrapment. Similar studies for comparison were also carried out on 6-mercaptopurine (6-MP), of which AZA is a prodrug. AZA and also 6-MP show higher encapsulation efficiencies in...

journal_title：Journal of microencapsulation

authors： Gulati M,Grover M,Singh M,Singh S

更新日期：1998-07-01 00:00:00

abstract：:Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...

journal_title：Journal of microencapsulation

authors： Shu XZ,Zhu KJ

更新日期：2001-03-01 00:00:00

abstract：:Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemic...

journal_title：Journal of microencapsulation

authors： Lalla JK,Ahuja PL

更新日期：1991-01-01 00:00:00

abstract：:Nanoparticles and microspheres made from human serum albumin are biodegradable and, as a physiological material, less cytocidal than cyanoacrylates. Therefore, they should be a suitable carrier system for targeting drugs into cells of the mononuclear phagocyte system. Nevertheless, the process of phagocytic uptake and...

journal_title：Journal of microencapsulation

authors： Schäfer V,von Briesen H,Rübsamen-Waigmann H,Steffan AM,Royer C,Kreuter J

更新日期：1994-05-01 00:00:00

abstract：:Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...

journal_title：Journal of microencapsulation

authors： Hogan SA,O'Riordan ED,O'Sullivan M

更新日期：2003-09-01 00:00:00

abstract：:PLGA microspheres with high drug loading and high encapsulation efficiency were fabricated by a novel solvent evaporation process-in-situ S/O/W process. Insulin was dissolved in DMSO and dispersed into DCM to form fine particles due to an anti-solvent effect. The in-situ formed suspension was then added into an aqueou...

journal_title：Journal of microencapsulation

authors： Bao W,Zhou J,Luo J,Wu D

更新日期：2006-08-01 00:00:00

abstract：:Aims: The study was carried out to synthesise and characterise the chitosan-encapsulated genistein (CHI-En/Gen) and determine its anti-cancer and anti-angiogenic properties.Methods: The cytotoxic and anti-angiogenic activity of CHI-En/Gen was performed using MTT and chorioallantoic membrane assay. The molecular action...

journal_title：Journal of microencapsulation

authors： Rahmani F,Karimi E,Oskoueian E

更新日期：2020-06-01 00:00:00

abstract：:Sequential interpenetrating networks of poly(methacrylic acid) and poly(vinyl alcohol) have been prepared and cross-linked with glutaraldehyde to obtain pH sensitive microspheres by a water-in-oil emulsification method. Microspheres have been used to deliver the chosen model anti-inflammatory drug viz., ibuprofen to t...

journal_title：Journal of microencapsulation

authors： Mundargi RC,Patil SA,Kulkarni PV,Mallikarjuna NN,Aminabhavi TM

更新日期：2008-06-01 00:00:00

abstract：:The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulat...

journal_title：Journal of microencapsulation

authors： Castro GA,Oréfice RL,Vilela JM,Andrade MS,Ferreira LA

更新日期：2007-08-01 00:00:00

abstract：:This article describes the development of a freeze-dried formulation of chitosan (CS) nanocapsules containing docetaxel (DCX) and the evaluation of its efficacy in the NCI-H460 cancer cell line. More specifically, two prototypes of nanocapsules differing in their coating, CS alone or in combination with poloxamer 188 ...

journal_title：Journal of microencapsulation

authors： Lozano MV,Esteban H,Brea J,Loza MI,Torres D,Alonso MJ

更新日期：2013-01-01 00:00:00

abstract：:In this study, we evaluated a system for oral vaccine delivery, consisting of liposomes coated first with a layer of tremella and then with an outer layer of acid-induced alginate. In vitro release studies showed that the triple layer of alginate-tremella-liposomes was more resistant to an acidic pH and modulated the ...

journal_title：Journal of microencapsulation

authors： Cheng HC,Chang CY,Hsieh FI,Yeh JJ,Chien MY,Pan RN,Deng MC,Liu DZ

更新日期：2011-01-01 00:00:00

abstract：:Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...

journal_title：Journal of microencapsulation

authors： Wang L,Ma Y,Gu Y,Liu Y,Zhao J,Yan B,Wang Y

更新日期：2018-05-01 00:00:00

abstract：:Encapsulated vitro-derived apical buds of M.26 apple rootstock (Malus pumila Mill) can be employed for the formation of the synthetic seed. Satisfactory levels of conversion (plantlets from synthetic seed) can be achieved if there are adequate (i) rooting induction treatment, (ii) protocol of encapsulation, and (iii) ...

journal_title：Journal of microencapsulation

authors： Micheli M,Pellegrino S,Piccioni E,Standardi A

更新日期：2002-05-01 00:00:00

abstract：:Radioembolization is used in diagnostic imaging of the lungs and for radioembolization therapy of hepatic tumours. Presently, 99mTc labelled macroaggregates or microspheres of human serum albumin (HAM) are used for this purpose. Poly lactic acid (PLA) is biodegradable, like HAM, and, unlike HAM, is not a blood product...

journal_title：Journal of microencapsulation

authors： Ergün EL,Ercan MT,Selek H,Kaş HS,Ruacan S,Unsal IS,Mutlu M

更新日期：2000-07-01 00:00:00

abstract：:In recent years, wormwood has been successfully applied in various fields, such as flavouring agent, plant dye, insect repellent and medical product. Wormwood oil encapsulated microcapsules with continuous release behaviours would be further applied in the health care textiles. Here, wormwood oil encapsulated microcap...

journal_title：Journal of microencapsulation

authors： Wang L,Li T,Xin B,Liu Y,Zhang F

更新日期：2020-06-01 00:00:00