Abstract：
:Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated by turbidimetric titration. The results indicate that there are electrostatic interactions between the above anions and chitosan in a certain region of solution pH (1.0-7.5 for sulphate/chitosan, 4.5-7.5 for citrate/chitosan and 1.9-7.5 for tripolyphosphate/chitosan), that is related to the natural characteristics of the anions. Out of the pH region where anions interact with chitosan, no microspheres were formed. However, even in the pH region where anions can interact with chitosan, only irregular microparticles were obtained in the case of the conventional emulsification and ionotropic gelation method, while spherical microspheres with diameters in the range of tens of microns were obtained when a modified process was employed. The key point of the modified process is the introduction of gelatin and allowing the ionic cross-linking process of chitosan/gelatin w/o emulsions to take place under coagulation conditions at a low temperature. The surface of sodium sulphate cross-linked chitosan/gelatin and sodium citrate cross-linked chitosan/gelatin microspheres was very smooth, but large gaps were observed on the surface of tripolyphosphate/chitosan microspheres. The increase of stirring speed led to a decrease in diameter and a narrowing in size distribution.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Shu XZ,Zhu KJdoi
10.1080/02652040010000415subject
Has Abstractpub_date
2001-03-01 00:00:00pages
237-45issue
2eissn
0265-2048issn
1464-5246journal_volume
18pub_type
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：2020-12-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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更新日期：2000-03-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.958203
更新日期：2015-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2002-03-01 00:00:00
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更新日期：1999-03-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1035683
更新日期：2015-01-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055243
更新日期：2001-11-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400288292
更新日期：2000-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2003-11-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652048509049572
更新日期：1985-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2006-02-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049509010294
更新日期：1995-05-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2014-01-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
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更新日期：1995-07-01 00:00:00
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更新日期：2011-01-01 00:00:00
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更新日期：1992-01-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2014-01-01 00:00:00
abstract：:The objective of this study is to explore the influence of polyvinylpyrrolidone (PVP) quantity on the solubility, crystallinity and oral bioavailability of poorly water-soluble fenofibrate in solvent-evaporated microspheres. Numerous microspheres were prepared with fenofibrate, sodium lauryl sulphate (SLS) and PVP usi...
journal_title：Journal of microencapsulation
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更新日期：2016-06-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2006-12-01 00:00:00
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：1987-04-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：1994-05-01 00:00:00
abstract：:Cross-linked albumin microcapsules were prepared, using a polycondensation interfacial process. Doxorubicin was incorporated in these microcapsules by simple adsorption from aqueous solution. Increasing the extent of cross-linkage of the microcapsule walls by either increasing the cross-linking agent concentration or ...
journal_title：Journal of microencapsulation
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doi：10.3109/02652048809064170
更新日期：1988-07-01 00:00:00
