Abstract：
:Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may not be effective due to damaged vasculature. In this study, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) rods containing 7, 14 and 22% (mol) 3-hydroxyvalerate were loaded with sulbactam:cefoperazone or gentamicin, and their antibiotic release behaviours were studied under in vitro conditions in physiological phosphate buffer at room temperature. The release patterns were representative of release from monolithic devices where a rapid early release phase is followed by a slower and prolonged release. With PHBV 22 rods, the latter phase continued for approximately 2 months. This duration is critical because a proper antibiotic therapy of IRO requires the minimal effective concentration for at least 6 weeks. After in vitro release, voids with sharp edges were detected on the rods, indicating that the drug crystals dissolved but the polymer did not undergo erosion within this test period. Changing the polymer:drug ratio from 2:1 to 20:1 substantially decreased the drug release rate. A change of polymer type, however, did not lead to any detectable changes in the release patterns. Gentamicin release also followed a similar pattern, except that the concentration of the drug in the release medium exhibited a decrease after long release periods, indicating degradation (or decomposition) of the antibiotic in the release medium.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Gurselt I,Yagmurlu F,Korkusuz F,Hasirci Vdoi
10.1080/02652040110065413subject
Has Abstractpub_date
2002-03-01 00:00:00pages
153-64issue
2eissn
0265-2048issn
1464-5246journal_volume
19pub_type
杂志文章abstract：:The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...
journal_title：Journal of microencapsulation
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abstract：:To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or po...
journal_title：Journal of microencapsulation
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doi：10.3109/02652048.2012.668957
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abstract：:The effect of lecithin and starch on viability of alginate encapsulated probiotics was determined at different temperatures. Probiotic organisms (1% v/v>10Log CFU ml(-1)) were encapsulated using alginate (2% w/v), gelatinized starches (2% w/v) and lecithin (0-4% w/v) and stored in sealed containers at 4, 23 and 37 deg...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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doi：10.3109/02652049609026029
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abstract：:The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled r...
journal_title：Journal of microencapsulation
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doi：10.1080/026520400288382
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abstract：:Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...
journal_title：Journal of microencapsulation
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doi：10.1080/02652040210140472
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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abstract：:This work demonstrates Box-Behnken design (BBD)'s capability in exploring scientific principles governing a process, different from its use in process optimisation. We have investigated nanoprecipitation (NP) of temozolomide with polycaprolactone. Five factors, surfactant, stirring speed (SS), dropping rate (DR), phas...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.950710
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abstract：:Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morp...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of microencapsulation
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更新日期：2016-06-01 00:00:00
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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abstract：:PLGA microspheres with high drug loading and high encapsulation efficiency were fabricated by a novel solvent evaporation process-in-situ S/O/W process. Insulin was dissolved in DMSO and dispersed into DCM to form fine particles due to an anti-solvent effect. The in-situ formed suspension was then added into an aqueou...
journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
pub_type： 杂志文章
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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abstract：:The present research work was aimed at development and optimization of alginate mucoadhesive microspheres of carvedilol for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres were prepared by a water-in-oil (w/o) ...
journal_title：Journal of microencapsulation
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abstract：:The present study describes the development of a new cyclosporine formulation based on polycaprolactone (PCL) microspheres (MS) prepared by the solvent evaporation method. Ternary phase diagrams were used to identify the domains where MS were formed. The application of central composite designs established the influen...
journal_title：Journal of microencapsulation
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更新日期：2002-01-01 00:00:00
abstract：:One of the main challenges in radiation oncology is to overcome the resistance of cancer cells against treatment by molecular targeted approaches. Among the most promising targets is the inhibitor of apoptosis protein survivin, known to be associated with increased tumour aggressiveness and therapy resistance. The obj...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.680511
更新日期：2012-01-01 00:00:00
abstract：:The transport pathway of PBCA nanoparticles through the rabbit cornea and conjunctiva was studied using fluorescence microscopy. Nanoparticles were produced by an emulsion-polymerization process, purified by a GPC procedure, and labelled with rhodamine 6G or propidium iodide as fluorescent laser dyes. The stability of...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：1991-10-01 00:00:00
abstract：:The purpose of this study was to assess the antioxidant and anti-inflammatory potential of liposomal formulations enriched with Hypericum hookerianum (Hyp) aqueous extracts. Cotyledon segments derived from protocorms of H. hookerianum were cultured on Murashige and Skoog (MS) media supplemented with Kinetin (KN, 1 mgl...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
abstract：:Microencapsulation aims to protect polyunsaturated fatty acids against oxidation by embedding oil droplets in a solid matrix. The effect of the oil droplet size on the oxidation was evaluated under consideration of the non-encapsulated oil and the powder particle size. An O/W emulsion (1.6%(w/w) soy protein; 30.4%(w/w...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1713243
更新日期：2020-03-01 00:00:00
