Abstract：
:The size dependent and size independent contributions to the mechanical properties of poly(ethyleneglycol) microspheres with encapsulated air, made for medical ultrasound imaging, have been studied. A relation between the size of microspheres in a reference group and their acoustic attenuation efficacy was derived by partial least square regression. The developed model was used to estimate acoustic attenuation as a function of the measured size distribution for various preparations made during formulation and process studies. The ratio between the measured attenuation and model estimated attenuation was then used to evaluate variations in the mechanical properties of the polymer shell and the contribution of such variations to the acoustical properties of the substance. The statistical parameter was compared with results for the mechanical compressibility derived from a theoretical approach and the results from the two methods mutually confirmed each other. The statistical procedure outlined has been found applicable for studies of other particulate products with size dependent in vitro or in vivo properties.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Dyrstad K,Sontum PC,Hoff Ldoi
10.1080/026520400288292subject
Has Abstractpub_date
2000-05-01 00:00:00pages
323-30issue
3eissn
0265-2048issn
1464-5246journal_volume
17pub_type
杂志文章abstract：PURPOSE:To develop a stable and reproducible modified release pellet formulation containing ibuprofen. METHODS:Using extrusion-spheronization technology to produce pellets. RESULTS:The percentage yield, size distribution and overall pellet shape within the desired size range of 1000-1400 microm was found to be depend...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500162535
更新日期：2005-09-01 00:00:00
abstract：:The aim was to study the effect of the type of polymer solvent on characteristics of microspheres produced by spray drying. The water-soluble model protein, bovine serum albumin (BSA) was microencapsulated into biodegradable poly(D,L-lactic acid) using the following 10 different polymer solvents: acetaldehyde dimethyl...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049509051129
更新日期：1995-01-01 00:00:00
abstract：:Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1202346
更新日期：2016-08-01 00:00:00
abstract：:Prototype fragrances, prepared from common fragrance components, were extracted with water, recovered, and characterized by gas chromatography before and after the water treatment, revealing a significant loss of the more water-soluble components. Unextracted prototype fragrances were also microencapsulated by a gelat...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049209021244
更新日期：1992-07-01 00:00:00
abstract：:The present research work was aimed at development and optimization of alginate mucoadhesive microspheres of carvedilol for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres were prepared by a water-in-oil (w/o) ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802456726
更新日期：2009-08-01 00:00:00
abstract：:Nanoparticles prepared of human serum albumin (HSA) represent promising carriers for drug delivery. Desolvating procedure is a common method to obtain protein-based particles. However process parameters have a great influence on size, size distribution and particle yield of the resulting formulation. Therefore, it is ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.635218
更新日期：2012-01-01 00:00:00
abstract：:The transport pathway of PBCA nanoparticles through the rabbit cornea and conjunctiva was studied using fluorescence microscopy. Nanoparticles were produced by an emulsion-polymerization process, purified by a GPC procedure, and labelled with rhodamine 6G or propidium iodide as fluorescent laser dyes. The stability of...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049109021873
更新日期：1991-10-01 00:00:00
abstract：:The present study describes the development of a new cyclosporine formulation based on polycaprolactone (PCL) microspheres (MS) prepared by the solvent evaporation method. Ternary phase diagrams were used to identify the domains where MS were formed. The application of central composite designs established the influen...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055270
更新日期：2002-01-01 00:00:00
abstract：:Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement,...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1393113
更新日期：2017-12-01 00:00:00
abstract：:The soft microcapsules containing eucalyptus oil, ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the water-in-oil-in-water type multiple (W/O)/W emulsion. The diameters of the microcapsules and the content and the mi...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1403494
更新日期：2017-12-01 00:00:00
abstract：:Hyaluronidase is a protein whose enzymatic activity is successfully employed in extravasation therapy. Taking into account that several proteins (e.g. gelatin and albumin) have been employed as natural polymers for the preparation of microspheres, this work approaches a comprehensive investigation on hyaluronidase inj...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809006838
更新日期：1998-01-01 00:00:00
abstract：:The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1375039
更新日期：2017-11-01 00:00:00
abstract：:Vascular endothelial growth factor receptor (VEGFR) is over-expressed on a variety of tumour cells and tumour neovasculature, and so becomes well-documented target for cancer treatment. This study was designed to evaluate the cellular targeting and anti-tumor potency of VEGF-conjugated nanoparticles (VEGF-NPs). The po...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1035683
更新日期：2015-01-01 00:00:00
abstract：:The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499289077
更新日期：1999-05-01 00:00:00
abstract：:In this study, ethylcellulose and acrylate-methacrylate copolymer (Eudragit RL 100, Eudragit RS 100) membranes were prepared by using appropriate types and amounts of plasticizers. Thirty percent and 20% of triacetin based on polymer weight were found to be appropriate plasticizers for ethylcellulose membranes and acr...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049609026048
更新日期：1996-11-01 00:00:00
abstract：:Polyurethane modified with polylactic acid microcapsules were fabricated for controlled release of chlorpyrifos (one of the high usage solid phosphorous insecticides) via interfacial polymerisation with diphenylmethane diisocyanate, polyether triol, 1,4-butanediol and polylactic acid as modifier. The structure, morpho...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1599075
更新日期：2019-01-01 00:00:00
abstract：:The purpose of the present study was to provide further insights on the applicability of microencapsulation using emulsification method, to immobilise Clostridium acetobutylicum ATCC 824 spores, for biobutanol production. The encapsulated spores were revived using heat shock treatment and the fermentation efficiency o...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1017617
更新日期：2015-01-01 00:00:00
abstract：:Catechin (CT) is natural molecule proved for antidiabetic activity. Clinical application of CT is highly restricted because of its low bioavailability and ineffectiveness in in vivo conditions. Therefore, the main objective of the present investigation was to formulate CT-loaded Eudragit RS 100 microparticles and eval...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1337248
更新日期：2017-06-01 00:00:00
abstract：:The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400417667
更新日期：2000-09-01 00:00:00
abstract：:This work investigated the means for the efficient encapsulation of muramyl dipeptide (MDP) in poly(epsilon-caprolactone) (PCL) microparticles (MP) by a solvent evaporation method in order to optimize the effect of the adjuvant for oral immunization. Therefore, the influence of MDP concentration in the inner aqueous p...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499288799
更新日期：1999-09-01 00:00:00
abstract：:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040903515508
更新日期：2010-01-01 00:00:00
abstract：AIMS:This study was aimed to develop Isotretinoin (ITN) and α-tocopherol acetate (α-TA) loaded solid lipid nanoparticle topical gel for better skin sensitivity and potentiation of efficacy. METHODS:ITN and α-TA-loaded solid lipid nanoparticles (AE-SLN) were prepared by microemulsion method with glyceryl mono-stearate ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1823499
更新日期：2020-12-01 00:00:00
abstract：:Emulsions of menhaden oil and sodium caseinate (NaCas) incorporating carbohydrates of varying dextrose equivalence (DE) were spray-dried to yield encapsulated fish oil powders. The effects of carbohydrate DE (5.5-38), core/wall ratio and NaCas/carbohydrate ratio on microencapsulation efficiency (ME) and oxidative stab...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000151974
更新日期：2003-09-01 00:00:00
abstract：:Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028424
更新日期：1990-01-01 00:00:00
abstract：:Radioembolization is used in diagnostic imaging of the lungs and for radioembolization therapy of hepatic tumours. Presently, 99mTc labelled macroaggregates or microspheres of human serum albumin (HAM) are used for this purpose. Poly lactic acid (PLA) is biodegradable, like HAM, and, unlike HAM, is not a blood product...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400405750
更新日期：2000-07-01 00:00:00
abstract：:This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1409819
更新日期：2018-01-01 00:00:00
abstract：:Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048609021799
更新日期：1986-10-01 00:00:00
abstract：:This article describes the development of a freeze-dried formulation of chitosan (CS) nanocapsules containing docetaxel (DCX) and the evaluation of its efficacy in the NCI-H460 cancer cell line. More specifically, two prototypes of nanocapsules differing in their coating, CS alone or in combination with poloxamer 188 ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.714411
更新日期：2013-01-01 00:00:00
abstract：:This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.651503
更新日期：2012-01-01 00:00:00
abstract：:The influence of drug particle size on the production of enteric beads by a polymer precipitation technique was investigated. Drug particle dimensions are known to play an important role in most microencapsulation techniques. Bead morphology was greatly influenced by drug particle size, and spherical shaped beads coul...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040050161729
更新日期：2000-11-01 00:00:00
