Abstract:
AIMS:This study was aimed to develop Isotretinoin (ITN) and α-tocopherol acetate (α-TA) loaded solid lipid nanoparticle topical gel for better skin sensitivity and potentiation of efficacy. METHODS:ITN and α-TA-loaded solid lipid nanoparticles (AE-SLN) were prepared by microemulsion method with glyceryl mono-stearate as lipid and tween 80: butanol as surfactantmix and characterised. AE-SLN gel was evaluated for physicochemical characteristics, drug release, skin irritation and anti-acne activity in rats. RESULTS:AE-SLNs had mean particle size of 193.4 nm (zeta-potential -29 mV) and entrapment efficiency of 84%w/w for ITN and 77.4%w/w for α-TA. AE-SLN gel showed sustained drug release for 24 h with a final cumulative release of 95.8% w/w and 89.1%w/w for ITN and α-TA. AE-SLN gel showed no erythema or edoema in rabbits and potent efficacy in rat model of acne. CONCLUSION:In conclusion, AE-SLN gel has the potential to use as a non-irritant topical formulation for the treatment of acne.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Gupta S,Wairkar S,Bhatt LKdoi
10.1080/02652048.2020.1823499subject
Has Abstractpub_date
2020-12-01 00:00:00pages
557-565issue
8eissn
0265-2048issn
1464-5246journal_volume
37pub_type
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