Isotretinoin and α-tocopherol acetate-loaded solid lipid nanoparticle topical gel for the treatment of acne.

Abstract:

AIMS:This study was aimed to develop Isotretinoin (ITN) and α-tocopherol acetate (α-TA) loaded solid lipid nanoparticle topical gel for better skin sensitivity and potentiation of efficacy. METHODS:ITN and α-TA-loaded solid lipid nanoparticles (AE-SLN) were prepared by microemulsion method with glyceryl mono-stearate as lipid and tween 80: butanol as surfactantmix and characterised. AE-SLN gel was evaluated for physicochemical characteristics, drug release, skin irritation and anti-acne activity in rats. RESULTS:AE-SLNs had mean particle size of 193.4 nm (zeta-potential -29 mV) and entrapment efficiency of 84%w/w for ITN and 77.4%w/w for α-TA. AE-SLN gel showed sustained drug release for 24 h with a final cumulative release of 95.8% w/w and 89.1%w/w for ITN and α-TA. AE-SLN gel showed no erythema or edoema in rabbits and potent efficacy in rat model of acne. CONCLUSION:In conclusion, AE-SLN gel has the potential to use as a non-irritant topical formulation for the treatment of acne.

journal_name

J Microencapsul

authors

Gupta S,Wairkar S,Bhatt LK

doi

10.1080/02652048.2020.1823499

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

557-565

issue

8

eissn

0265-2048

issn

1464-5246

journal_volume

37

pub_type

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