Development of a new delivery system consisting in 'drug-in cyclodextrin-in PLGA nanoparticles'.


:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-betaCD-loaded NPs) up to 100% (drug-methylbetaCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.


J Microencapsul


Mura P,Maestrelli F,Cecchi M,Bragagni M,Almeida A




Has Abstract


2010-01-01 00:00:00












  • Influence of alginate cross-linking method on neurite response to microencapsulated neurotrophin-producing fibroblasts.

    abstract::Transplantation of cells genetically modified to produce neurotrophins is a promising spinal cord repair strategy. Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF. We here compared...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Francis NL,Shanbhag MS,Fischer I,Wheatley MA

    更新日期:2011-01-01 00:00:00

  • Microencapsulation of Lactobacillus rhamnosus GG with flaxseed mucilage using co-extrusion technique.

    abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Lai K,How Y,Pui L

    更新日期:2020-12-28 00:00:00

  • Preparation of soft microcapsules containing multiple core materials with interfacial dehydration reaction using the (W/O)/W emulsion.

    abstract::The soft microcapsules containing eucalyptus oil, ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the water-in-oil-in-water type multiple (W/O)/W emulsion. The diameters of the microcapsules and the content and the mi...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Taguchi Y,Suzuki T,Saito N,Yokoyama H,Tanaka M

    更新日期:2017-12-01 00:00:00

  • An investigation of internal phase losses during the microencapsulation of fragrances.

    abstract::Prototype fragrances, prepared from common fragrance components, were extracted with water, recovered, and characterized by gas chromatography before and after the water treatment, revealing a significant loss of the more water-soluble components. Unextracted prototype fragrances were also microencapsulated by a gelat...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Flores RJ,Wall MD,Carnahan DW,Orofino TA

    更新日期:1992-07-01 00:00:00

  • Release characteristics of microspheres prepared by co-spray drying Actinobacillus pleuropneumoniae antigens and aqueous ethyl-cellulose dispersion.

    abstract::Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the ente...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Liao CW,Cheng IC,Yeh KS,Lin FY,Weng CN

    更新日期:2001-05-01 00:00:00

  • Effect of encapsulation of mefenamic acid with cationic Eudragit E on its bioavailability and gastric ulcerogenic activity in rabbits.

    abstract::Encapsulation of mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug with cationic acrylic resin, Eudragit E, was carried out using a fluidized-bed granulator (Glatt AG). Three drug:polymer ratios were prepared using 50 ml of 1, 2.5 and 5 per cent w/v aqueous suspension of Eudragit to coat 100 mg powde...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ramadan EM,el-Helw A,el-Said Y

    更新日期:1987-04-01 00:00:00

  • Assessment of formulated amodiaquine microparticles in Leishmania donovani infected rats.

    abstract::The aim of this study was to formulate, characterise and evaluate the activity of amodiaquine microparticles against Leishmania donovani. Microparticles were formulated by encapsulating the drug in bovine serum albumin using the spray-dryer method. The microparticles were evaluated for size, zeta potential, drug conte...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Nettey H,Allotey-Babington GL,Somuah I,Banga NB,Afrane B,Amponsah SK,Annor H,Darko H,Hanson K,Aidoo A,Broni MN,Sasu C,Nyarko A

    更新日期:2017-02-01 00:00:00

  • Chitosan/gelatin microspheres prepared by modified emulsification and ionotropic gelation.

    abstract::Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Shu XZ,Zhu KJ

    更新日期:2001-03-01 00:00:00

  • Production of monodisperse silica gel microspheres for bioencapsulation by extrusion into an oil cross-flow.

    abstract::Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Benson JJ,Wackett LP,Aksan A

    更新日期:2016-08-01 00:00:00

  • Water-in-oil-in-water double emulsions loaded with chlorogenic acid: release mechanisms and oxidative stability.

    abstract::Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Dima C,Dima S

    更新日期:2018-09-01 00:00:00

  • Studies on the in vitro release characteristics of ibuprofen-loaded polystyrene microparticles.

    abstract::Ibuprofen-loaded polystyrene microparticles were prepared by the emulsion-solvent evaporation process from an aqueous system. The effects of different parameters on the drug content and on the release of the drug from the microparticles were investigated. The drug content, in all the formulations, was less than the th...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Tamilvanan S,Sa B

    更新日期:2000-01-01 00:00:00

  • Preparation of polyurea/melamine formaldehyde double-layered self-healing microcapsules and investigation on core fraction.

    abstract::Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ming Y,Hu J,Xing J,Wu M,Qu J

    更新日期:2016-06-01 00:00:00

  • Oxprenolol release from bioadhesive gelatin/poly(acrylic acid) microspheres.

    abstract::Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Leucuta SE,Ponchel G,Duchêne D

    更新日期:1997-07-01 00:00:00

  • Reinvestigating nanoprecipitation via Box-Behnken design: a systematic approach.

    abstract::This work demonstrates Box-Behnken design (BBD)'s capability in exploring scientific principles governing a process, different from its use in process optimisation. We have investigated nanoprecipitation (NP) of temozolomide with polycaprolactone. Five factors, surfactant, stirring speed (SS), dropping rate (DR), phas...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Singh Y,Ojha P,Srivastava M,Chourasia MK

    更新日期:2015-01-01 00:00:00

  • Development of liposomal amphotericin B formulation.

    abstract::A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章,评审


    authors: Gulati M,Bajad S,Singh S,Ferdous AJ,Singh M

    更新日期:1998-03-01 00:00:00

  • Polymethylene-co-guanidine based capsules: a mechanistic study of the formation using alginate and cellulose sulphate.

    abstract::Capsules have been prepared based on a polyanion blend of sodium alginate and sodium cellulose sulphate, gelled in the presence of calcium chloride and sodium chloride. In a second step a membrane was formed via the addition of polymethylene-co-guanidine (PMCG), an oligocation. A mechanistic study examined the influen...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Renken A,Hunkeler D

    更新日期:2007-02-01 00:00:00

  • pH-dependent release property of alginate beads containing calcium carbonate particles.

    abstract::Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a sa...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Han MR,Kwon MC,Lee HY,Kim JC,Kim JD,Yoo SK,Sin IS,Kim SM

    更新日期:2007-12-01 00:00:00

  • Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen.

    abstract::Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Goto S,Kawata M,Nakamura M,Maekawa K,Aoyama T

    更新日期:1986-10-01 00:00:00

  • Preparation and characterization of textile-based carrier systems for anal fissure treatment.

    abstract::Anal fissure is common and painful disease of anorectum. In this study, microparticles containing nifedipine and lidocaine HCl were prepared by spray drying and applied to bio-degradable and bio-stable tampons. Characterization of microparticles was determined by visual analyses, mass yield, particle size measurement,...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Sarıışık AM,Karavana SY,Türkoğlu GC,Rençber S,Önder T

    更新日期:2017-12-01 00:00:00

  • Formation of essential oil containing microparticles comprising a hydrogenated vegetable oil matrix and characterisation thereof.

    abstract::Microparticles with different essential oil concentrations 0, 75, 150, 225 and 300 gkg-1, (g of essential oil per kg of microparticles), were produced by dispersing the essential oils within a hydrogenated vegetable fat matrix and forming spherical solid particles by spray-chilling. Size distribution, flowability, sur...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gottschalk P,Brodesser B,Poncelet D,Jaeger H,Rennhofer H,Cole S

    更新日期:2018-09-01 00:00:00

  • Preparation of chitosan microspheres using membrane emulsification and its size modelling.

    abstract::The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 x 10(5) to 0.8 x 10(5) Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was vari...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Park SB,Jeon YJ,Haam S,Park HY,Kim WS

    更新日期:2004-08-01 00:00:00

  • Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro.

    abstract::Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Rubas W,Banerjea AC,Gallati H,Speiser PP,Joklik WK

    更新日期:1990-07-01 00:00:00

  • Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix.

    abstract::The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ustariz-Peyret C,Coudane J,Vert M,Kaltsatos V,Boisramené B

    更新日期:2000-09-01 00:00:00

  • Physicochemical characterization of protamine-phosphorothioate nanoparticles.

    abstract::Protamine-oligonucleotide nanoparticles represent effective colloidal drug carriers for antisense phosphorothioate oligonucleotides (PTO). This study describes improvements in particle preparation and the physicochemical properties of the complexes prepared. The influence of component concentrations, length of the PTO...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Lochmann D,Vogel V,Weyermann J,Dinauer N,von Briesen H,Kreuter J,Schubert D,Zimmer A

    更新日期:2004-09-01 00:00:00

  • Resveratrol solid lipid microparticles as dry powder formulation for nasal delivery, characterization and in vitro deposition study.

    abstract::This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical character...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Martignoni I,Trotta V,Lee WH,Loo CY,Pozzoli M,Young PM,Scalia S,Traini D

    更新日期:2016-12-01 00:00:00

  • Development, optimization and in vitro evaluation of alginate mucoadhesive microspheres of carvedilol for nasal delivery.

    abstract::The present research work was aimed at development and optimization of alginate mucoadhesive microspheres of carvedilol for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres were prepared by a water-in-oil (w/o) ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Patil SB,Sawant KK

    更新日期:2009-08-01 00:00:00

  • Self-assembly pH-sensitive chitosan/alginate coated polyelectrolyte complexes for oral delivery of insulin.

    abstract::Polyelectrolyte complexes (PEC) provide new opportunities for controlled release system of drugs, and have potentials to address challenges on the way to effective oral insulin delivery. Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two opposit...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Chen T,Li S,Zhu W,Liang Z,Zeng Q

    更新日期:2019-01-01 00:00:00

  • Nifedipine encapsulated core-shell type nanoparticles based on poly(gamma-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers.

    abstract::The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was sl...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Jeong YI,Sun HS,Shim YH,Kim C,Park SH,Choi KC,Cho CS

    更新日期:2004-06-01 00:00:00

  • Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. II. Some process parameters influencing the preparation and properties of microspheres.

    abstract::D,L-polylactic acid (PLA) microspheres containing quinidine base and quinidine sulphate were prepared by the solvent evaporation method. The present study was carried out to examine how various process parameters in the aqueous phase influenced the preparation and properties of PLA-microspheres. The amount of drug tha...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Bodmeier R,McGinity JW

    更新日期:1987-10-01 00:00:00

  • Application of whey protein micro-bead coatings for enhanced strength and probiotic protection during fruit juice storage and gastric incubation.

    abstract:CONTEXT:Coated whey protein micro-beads may improve probiotic protection and provide delayed cell-release mechanisms. OBJECTIVE:Lactobacillus rhamnosus GG was encapsulated in whey protein micro-beads by droplet extrusion with coating via electrostatic deposition: primary-polysaccharide and secondary-whey protein. MAT...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Doherty SB,Auty MA,Stanton C,Ross RP,Fitzgerald GF,Brodkorb A

    更新日期:2012-01-01 00:00:00