Development of a new delivery system consisting in 'drug-in cyclodextrin-in PLGA nanoparticles'.

Abstract:

:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-betaCD-loaded NPs) up to 100% (drug-methylbetaCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.

journal_name

J Microencapsul

authors

Mura P,Maestrelli F,Cecchi M,Bragagni M,Almeida A

doi

10.3109/02652040903515508

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

479-86

issue

6

eissn

0265-2048

issn

1464-5246

journal_volume

27

pub_type

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