Abstract:
:A combined approach based on drug cyclodextrin (CD) complexation and loading into PLGA nanoparticles (NP) has been developed to improve oxaprozin therapeutic efficiency. This strategy exploits the solubilizing and stabilizing properties of CDs and the prolonged-release and targeting properties of PLGA NPs. Drug-loaded NPs, prepared by double-emulsion, were examined for dimensions, zeta-potential and entrapment efficiency. Solid-state studies demonstrated the absence of drug-polymer interactions and assessed the amorphous state of the drug-CD complex loaded into NPs. Drug release rate from NPs was strongly influenced by the presence and kind of CD used. The percentage released at 24 h varied from 16% (plain drug-loaded NPs) to 50% (drug-betaCD-loaded NPs) up to 100% (drug-methylbetaCD-loaded NPs). This result suggests the possibility of using CD complexation not only to promote, but also to regulate drug release rate from NPs, by selecting the proper type of CD or CD combination.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Mura P,Maestrelli F,Cecchi M,Bragagni M,Almeida Adoi
10.3109/02652040903515508subject
Has Abstractpub_date
2010-01-01 00:00:00pages
479-86issue
6eissn
0265-2048issn
1464-5246journal_volume
27pub_type
杂志文章abstract::Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs) was used to improve its oral bioavailability. In this work, we evaluat...
journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049809008248
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journal_title:Journal of microencapsulation
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abstract::This paper describes a novel approach to prepare and characterize calcium-shellac spheres as a carrier of a tooth whitening agent carbamide peroxide. Calcium-shellac spheres were prepared using an extrusion technique based on dropping aqueous ammonium shellac solution into calcium chloride solution. The effects of for...
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049309031522
更新日期:1993-07-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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doi:10.3109/02652049609052903
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049709051134
更新日期:1997-05-01 00:00:00
abstract::Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1692946
更新日期:2020-01-01 00:00:00
abstract::Polyurethane modified with polylactic acid microcapsules were fabricated for controlled release of chlorpyrifos (one of the high usage solid phosphorous insecticides) via interfacial polymerisation with diphenylmethane diisocyanate, polyether triol, 1,4-butanediol and polylactic acid as modifier. The structure, morpho...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract::In the previous report, microencapsulation of lipase employing a (w/o)/w multiple phase emulsion technique, with 2:1 polystyrene (PS)-SBR mixture being used as a wall material, was proposed. Catalysis of the encapsulated enzyme was investigated, and the hydrolysis of triacetin (triglyceride of acetic acid) was success...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048909019911
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009028424
更新日期:1990-01-01 00:00:00
abstract::Sub-100-nm nanoparticles were prepared from beta-lactoglobulin (BLG) with a narrow size distribution by a desolvation method using glutaraldehyde for cross-linking. With pre-heating of the BLG solution to 60 degrees C and subsequent pH readjustment to 9.0, nanoparticles of 59 +/- 5 nm were obtained with improved unifo...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040601035143
更新日期:2006-12-01 00:00:00
abstract::Ionotropic gelation was used to entrap sulindac into calcium alginate beads as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Beads were investigated in vitro for a possible sustained drug release and their use in vivo as a gastroprotective system for sulindac. Process parameters such a...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701298153
更新日期:2007-06-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章,评审
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更新日期:1993-04-01 00:00:00
abstract::Background: Lavender oil consists of around 100 components and is susceptible to volatilisation and degradation reactions. Aim: Microencapsulate lavender oil by spray drying using a biocompatible polymeric blend of gum acacia and maltodextrin to protect the oil components. Effect of total polymer content, oil loading,...
journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1409819
更新日期:2018-01-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049209021244
更新日期:1992-07-01 00:00:00
abstract::Proliposomes of ibuprofen were successfully prepared using effervescent granules as solid carriers of dried phospholipids along with other lipids (soyabean lecithin, stearylamine and cholesterol). Liposomes of regular size with uniform size distribution resulted when proliposomal formulations were hydrated under the e...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009040467
更新日期:1990-10-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00
abstract::A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment f...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
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更新日期:2002-11-01 00:00:00
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journal_title:Journal of microencapsulation
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of microencapsulation
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of microencapsulation
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更新日期:2017-12-01 00:00:00
abstract::The effect of process variables such as nozzle size, flow-rate of dispersed phase, inter-electrode distance, and presence of an acid acceptor and a thickening agent in the dispersed phase, on the production and size distribution of nylon 6-10 microcapsules prepared by interfacial polymerization in a high-voltage elect...
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