Abstract：
:Proliposomes of ibuprofen were successfully prepared using effervescent granules as solid carriers of dried phospholipids along with other lipids (soyabean lecithin, stearylamine and cholesterol). Liposomes of regular size with uniform size distribution resulted when proliposomal formulations were hydrated under the effervescence produced by the production of carbon dioxide gas. The inert atmosphere of carbon dioxide gas prevents the chance of oxidative degradation of phospholipids. The size distribution of liposomes was noted to be related to the degree of agitation provided by effervescence. Encapsulation efficiency of liposomes derived from proliposomes was shown to be nearly 100 per cent. Preparations were shown to be quite stable at 20 degrees C when stored under an umbrella of nitrogen. The enhanced anti-inflammatory activity of ibuprofen entrapped in liposomes was exhibited when compared with plain ibuprofen following intravenous administration using the carrageenan induced paw oedema test.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Katare OP,Vyas SP,Dixit VKdoi
10.3109/02652049009040467subject
Has Abstractpub_date
1990-10-01 00:00:00pages
455-62issue
4eissn
0265-2048issn
1464-5246journal_volume
7pub_type
杂志文章abstract：:The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040802685241
更新日期：2009-12-01 00:00:00
abstract：:Redox-responsive magnetic protein microcapsules with Fe3O4 magnetic nanoparticles (MNPs) encapsulated inside have been obtained using a facile, cost-effective and fast sonochemical method from hen egg white proteins. Such prepared redox-responsive magnetic hen egg white protein microcapsules (MHEWPMCs) could be easily...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2015.1073389
更新日期：2015-01-01 00:00:00
abstract：:Ibuprofen-loaded polystyrene microparticles were prepared by the emulsion-solvent evaporation process from an aqueous system. The effects of different parameters on the drug content and on the release of the drug from the microparticles were investigated. The drug content, in all the formulations, was less than the th...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400288553
更新日期：2000-01-01 00:00:00
abstract：:The objective of this study was to prepare floating theophylline microspheres with zero order release profiles for use as buoyant reservoirs with increased retention time in the stomach. The microspheres were prepared by a modified emulsion-solvent evaporation method using a polymer mixture of cellulose acetate butyra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809008255
更新日期：1998-11-01 00:00:00
abstract：:Eudragit RS microspheres containing verapamil HCl for oral use were prepared using three different dispersing agents: aluminium tristearate, magnesium stearate and sucrose stearate, by a solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040310001637893
更新日期：2004-03-01 00:00:00
abstract：:Polylactide (PLA) and polylactide-co-glycolide (PLGA) particles entrapping rotavirus (strain SA11) were formulated using a solvent evaporation technique. To minimize denaturation of viral antigen during the emulsification process, serum albumin was used as a stabilizer. Use of NaHCO(3) and sucrose during the primary e...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802211709
更新日期：2009-03-01 00:00:00
abstract：:Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a sa...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701657820
更新日期：2007-12-01 00:00:00
abstract：:Polyelectrolyte complexes (PEC) provide new opportunities for controlled release system of drugs, and have potentials to address challenges on the way to effective oral insulin delivery. Here, an innovative pH-sensitive PEC for insulin oral administration was developed, which was formed by self-assembly of two opposit...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2019.1604846
更新日期：2019-01-01 00:00:00
abstract：:Bacampicillin hydrochloride has been microencapsulated to mask its very bitter taste. The objective of the study was to compare the in vitro release and bioavailability of bacampicillin hydrochloride from microcapsules coated with two principally different polymers: a water-insoluble polymer, ethylcellulose, and an ac...
journal_title：Journal of microencapsulation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/02652048509031556
更新日期：1985-04-01 00:00:00
abstract：:Microparticles with different essential oil concentrations 0, 75, 150, 225 and 300 gkg-1, (g of essential oil per kg of microparticles), were produced by dispersing the essential oils within a hydrogenated vegetable fat matrix and forming spherical solid particles by spray-chilling. Size distribution, flowability, sur...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1515998
更新日期：2018-09-01 00:00:00
abstract：CONTEXT:Flavonoids show promising anticancer potential but it is limited due to poor solubility. OBJECTIVE:The present investigation was to prepare Chrysin-Phospholipid complex loaded solid lipid nanoparticles (Ch-PC-SLNs) for improving its encapsulation as compared to that of Chrysin loaded SLNs (Ch-SLNs) and evaluat...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1559369
更新日期：2018-09-01 00:00:00
abstract：:The bioavailability of marketed nitrofurantoin capsules was compared to capsules filled with Gantrez-gelatin nitrofurantoin microcapsules of a core:coat ratio of 1:2. The collective results obtained from the analysis of urine samples of five volunteers indicated that nitrofurantoin microcapsules provided a prolonged r...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048809036727
更新日期：1988-10-01 00:00:00
abstract：AIMS:This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. METHODS:Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and po...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1792566
更新日期：2020-11-01 00:00:00
abstract：:The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 x 10(5) to 0.8 x 10(5) Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was vari...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040410001729304
更新日期：2004-08-01 00:00:00
abstract：:The action of two detergents, Triton X-100 and sodium dodecyl sulphate (SDS), on large, unilamellar liposomes was determined as liposome size variation, polydispersity and ability to release a soluble marker from liposomes. Triton X-100 produced stronger effects than SDS. Nevertheless, these differences in behaviour o...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009021838
更新日期：1990-04-01 00:00:00
abstract：:Protamine-oligonucleotide nanoparticles represent effective colloidal drug carriers for antisense phosphorothioate oligonucleotides (PTO). This study describes improvements in particle preparation and the physicochemical properties of the complexes prepared. The influence of component concentrations, length of the PTO...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040400000504
更新日期：2004-09-01 00:00:00
abstract：:N-lauroyl chitosan (NLCS) conjugates with different degrees of substitution (DS) of lauroyl group were synthesized and used to prepare surface modified poly(lactic-co-glycolic) acid (NLCS-PLGA) nanoparticles via hydrophobic interaction and ionic bond force. NLCS-PLGA nanoparticles had spherical shape with shell-core s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2013.824515
更新日期：2014-01-01 00:00:00
abstract：:Indomethacin-loaded dietheylaminoethyl trisacryl microspheres (DEAE-MS), originally designed for therapeutic embolization, were encapsulated using two methods: coacervation and solvent evaporation/extraction. This encapsulation was achieved using a biocompatible polymer, the PLGA 50 : 50, and aimed to control the rele...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701843388
更新日期：2008-03-01 00:00:00
abstract：:Nanoparticles and microspheres made from human serum albumin are biodegradable and, as a physiological material, less cytocidal than cyanoacrylates. Therefore, they should be a suitable carrier system for targeting drugs into cells of the mononuclear phagocyte system. Nevertheless, the process of phagocytic uptake and...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049409040455
更新日期：1994-05-01 00:00:00
abstract：:Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2016.1248512
更新日期：2016-12-01 00:00:00
abstract：:Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028424
更新日期：1990-01-01 00:00:00
abstract：:The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solut...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048609031560
更新日期：1986-04-01 00:00:00
abstract：:Phosphatidylcholine (from egg yolk)-cholesterol-stearylamine (7:2:2.25, molar ratio) liposomes when associated with cyclosporin A (phosphatidylcholine:cyclosporin A = 2:0.07, molar ratio) do not inhibit significantly the biosynthesis of [3H]polyglycerophosphatides and [3H]phosphatidylinositol in mitochondrial and micr...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048909098018
更新日期：1989-04-01 00:00:00
abstract：:To prepare the sustained release vitamin C carriers, vitamin C was successfully encapsulated in tripolyphosphate (TPP) cross-linked chitosan (TPP-chitosan) microspheres by the spray-drying method at different manufacturing conditions. Manufacturing parameters (inlet temperature, liquid flow rate, chitosan concentratio...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500435436
更新日期：2006-02-01 00:00:00
abstract：:Conditions of microencapsulation by in situ polycondensation, using melamine-formaldehyde as wall material, are influenced by the chemical nature of the core to encapsulate. In our study concerning the encapsulation of a photopolymerizable phase containing an electrically charged compound, it was necessary to modify t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049309031522
更新日期：1993-07-01 00:00:00
abstract：:Using liposomes radiolabelled by the 99mTechnetium-stannous chloride technique we have investigated the effect of surface charge on the stability of the isotope in vitro and in vivo. Dialysis of 99mTc-labelled positive, negative and neutral liposomes, which had been incubated in either saline or normal rat serum showe...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048909019907
更新日期：1989-01-01 00:00:00
abstract：:Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049709033835
更新日期：1997-07-01 00:00:00
abstract：:To overcome the recurrence problem in bladder tumours; nanoparticles with positive surface charge may improve interaction with biological membranes for intravesical administration. The aim of this study was to design, develop and evaluate (in vitro-in vivo) cationic nanoparticles based on chitosan, poly-L-lysine or po...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2012.668957
更新日期：2012-01-01 00:00:00
abstract：:Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2018.1559246
更新日期：2018-09-01 00:00:00
abstract：:An overview of biodegradable and biocompatible microcapsules and microspheres loaded with neuroactive substances, or cells producing neuroactive substances, and their role as drug delivery systems (DDS) for drug administration to the central nervous system (CNS) is given. In addition, closely related systems are also ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049509087248
更新日期：1995-07-01 00:00:00
