Cationic lipid emulsions as potential bioadhesive carriers for ophthalmic delivery of palmatine.

Abstract:

:Palmatine (PM) is a potent anti-infective agent used to treat eye diseases. However, PM is less effective for ocular application due to short residence time within the eyes. This study aimed to develop a cationic lipid emulsions (CLEs) for ophthalmic delivery of PM and evaluate its suitability in infection treatment. PM-loaded CLEs (PM-CLEs) were prepared through emulsifying/high-pressure homogenisation and characterised by particle size, ζ potential and morphology. The resulting PM-CLEs possessed a particle size of 192 nm and ζ potential of 45 mV around. In vitro release illustrated that PM was released less from CLEs. Corneal bioadhesion test showed that PM-CLEs exhibited an enhanced ocular residence time. Improved anti-infective activity was achieved in the model of fungus-induced keratitis. Furthermore, PM-CLEs demonstrated predominant cellular uptake and internalisation in the corneal epithelial cells. These results provide proof of concept that CLEs are promising bioadhesive carriers for ophthalmic delivery of PM.

journal_name

J Microencapsul

authors

Yin J,Xiang C,Lu G

doi

10.1080/02652048.2016.1248512

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

718-724

issue

8

eissn

0265-2048

issn

1464-5246

journal_volume

33

pub_type

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