Preparation of microcapsules from complex coacervation of Gantrez-gelatin. III. Bioavailability of nitrofurantoin microcapsules.

Abstract:

:The bioavailability of marketed nitrofurantoin capsules was compared to capsules filled with Gantrez-gelatin nitrofurantoin microcapsules of a core:coat ratio of 1:2. The collective results obtained from the analysis of urine samples of five volunteers indicated that nitrofurantoin microcapsules provided a prolonged release compared with that of the control formulation. Analysis of variance showed statistically significant differences between the control formulation and the capsule filled with the microcapsule. Non-significant intersubject variation was noticed.

journal_name

J Microencapsul

authors

Mortada SA,el Egaky MA,Motawi AM,el Khodery KA

doi

10.3109/02652048809036727

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

311-7

issue

4

eissn

0265-2048

issn

1464-5246

journal_volume

5

pub_type

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