pH-dependent release property of alginate beads containing calcium carbonate particles.

Abstract:

:Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a saturation manner. When no calcium carbonate was contained, the release exhibited no marked variation with pH and the values were 27-39%. On the other hand, in case calcium carbonate was included in the matrix of alginate beads, intensive release(40-50%) was achieved in acidic and neutral conditions and the degrees of release were suppressed in alkali conditions and the values were approximately 20%. The pH-sensitive release property is possibly because the particles of calcium carbonate embedded in the matrix of beads were leached out in acidic and neutral conditions, leaving cavities in the matrix. The cavities are likely to be main pathways for the release of blue dextran.

journal_name

J Microencapsul

authors

Han MR,Kwon MC,Lee HY,Kim JC,Kim JD,Yoo SK,Sin IS,Kim SM

doi

10.1080/02652040701657820

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

787-96

issue

8

eissn

0265-2048

issn

1464-5246

pii

782920607

journal_volume

24

pub_type

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