Abstract:
:Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a saturation manner. When no calcium carbonate was contained, the release exhibited no marked variation with pH and the values were 27-39%. On the other hand, in case calcium carbonate was included in the matrix of alginate beads, intensive release(40-50%) was achieved in acidic and neutral conditions and the degrees of release were suppressed in alkali conditions and the values were approximately 20%. The pH-sensitive release property is possibly because the particles of calcium carbonate embedded in the matrix of beads were leached out in acidic and neutral conditions, leaving cavities in the matrix. The cavities are likely to be main pathways for the release of blue dextran.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Han MR,Kwon MC,Lee HY,Kim JC,Kim JD,Yoo SK,Sin IS,Kim SMdoi
10.1080/02652040701657820subject
Has Abstractpub_date
2007-12-01 00:00:00pages
787-96issue
8eissn
0265-2048issn
1464-5246pii
782920607journal_volume
24pub_type
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