Formulation and evaluation of albumin microspheres and its enteric coating using a spray-dryer.

Abstract:

:This study optimized and evaluated the conditions for surface coating of microspheres using a spray-dryer. Four formulations of Bromophenol blue (BPB)-loaded albumin microspheres were prepared using a spray-dryer, cross-linked at different concentrations and time periods. One of the optimized formulations with the desired characteristics was selected for enteric coating with Eudragit L100-55. The procedure involved suspending BPB microspheres in polymer solution and spray-drying it. Four enteric coated formulations were prepared with different concentrations of microspheres in suspension (0.25 and 0.5%w/v) and polymer concentrations (0.25 and 0.5%w/v). Change in the mean particle size after coating was determined using a Laser Particle Counter. The surface coating technique employed did not significantly increase the particle size. Enteric coating efficiency was determined in simulated gastric fluid. Compared to the uncoated microspheres the cumulative amount of drug released from coated microspheres was significantly lower for 3 h, implying efficient surface coating.

journal_name

J Microencapsul

authors

Bejugam NK,Uddin AN,Gayakwad SG,D'Souza MJ

doi

10.1080/02652040802476187

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

577-83

issue

8

eissn

0265-2048

issn

1464-5246

pii

905299236

journal_volume

25

pub_type

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