Formulation and evaluation of albumin microspheres and its enteric coating using a spray-dryer.


:This study optimized and evaluated the conditions for surface coating of microspheres using a spray-dryer. Four formulations of Bromophenol blue (BPB)-loaded albumin microspheres were prepared using a spray-dryer, cross-linked at different concentrations and time periods. One of the optimized formulations with the desired characteristics was selected for enteric coating with Eudragit L100-55. The procedure involved suspending BPB microspheres in polymer solution and spray-drying it. Four enteric coated formulations were prepared with different concentrations of microspheres in suspension (0.25 and 0.5%w/v) and polymer concentrations (0.25 and 0.5%w/v). Change in the mean particle size after coating was determined using a Laser Particle Counter. The surface coating technique employed did not significantly increase the particle size. Enteric coating efficiency was determined in simulated gastric fluid. Compared to the uncoated microspheres the cumulative amount of drug released from coated microspheres was significantly lower for 3 h, implying efficient surface coating.


J Microencapsul


Bejugam NK,Uddin AN,Gayakwad SG,D'Souza MJ




Has Abstract


2008-12-01 00:00:00














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    abstract::Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...

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    authors: Benson JJ,Wackett LP,Aksan A

    更新日期:2016-08-01 00:00:00

  • Controlled release captopril microcapsules: effect of ethyl cellulose viscosity grade on the in vitro dissolution from microcapsules and tableted microcapsules.

    abstract::Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Singh J,Robinson DH

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  • An interpretative analysis of the effect of the surfactants used for the preparation of polyalkylcyanoacrylate nanoparticles on the release process.

    abstract::The release of fluorescein from polyethylcyanoacrylate (PECA) or polyisobutylcyanoacrylate (PICA) nanoparticles was affected by the surfactants used for the preparation. The different surfactants also modified the molecular weight, size and loading of the nanoparticles. However, these factors were not be responsible f...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Vandelli MA,Fresta M,Puglisi G,Forni F

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  • Functionality of protective colloids affecting the formation, size uniformity and morphology of drug-free polylactic acid microspheres.

    abstract::Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Lin SY,Chen KS,Teng HH

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  • Preparation of soft microcapsules containing multiple core materials with interfacial dehydration reaction using the (W/O)/W emulsion.

    abstract::The soft microcapsules containing eucalyptus oil, ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the water-in-oil-in-water type multiple (W/O)/W emulsion. The diameters of the microcapsules and the content and the mi...

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    authors: Taguchi Y,Suzuki T,Saito N,Yokoyama H,Tanaka M

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  • Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne.

    abstract::The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulat...

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    authors: Castro GA,Oréfice RL,Vilela JM,Andrade MS,Ferreira LA

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  • Formulation and in vitro-in vivo evaluation of ketoprofen-loaded albumin microspheres for intramuscular administration.

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    authors: Mathew ST,Devi SG,Prasanth VV,Vinod B

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  • Prolonged retention and in vivo evaluation of cationic nanoparticles loaded with Mitomycin C designed for intravesical chemotherapy of bladder tumours.

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    authors: Erdoğar N,Iskit AB,Mungan NA,Bilensoy E

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  • Nanobiotechnologic approach to a promising vaccine prototype for immunisation against leishmaniasis: a fast and effective method to incorporate GPI-anchored proteins of Leishmania amazonensis into liposomes.

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    authors: Colhone MC,Silva-Jardim I,Stabeli RG,Ciancaglini P

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  • A novel microparticulate vaccine for melanoma cancer using transdermal delivery.

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    authors: Bhowmik T,D'Souza B,Shashidharamurthy R,Oettinger C,Selvaraj P,D'Souza MJ

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  • Catechin-loaded Eudragit microparticles for the management of diabetes: formulation, characterization and in vivo evaluation of antidiabetic efficacy.

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    authors: Meena KP,Vijayakumar MR,Dwibedy PS

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  • Application of whey protein micro-bead coatings for enhanced strength and probiotic protection during fruit juice storage and gastric incubation.

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    authors: Doherty SB,Auty MA,Stanton C,Ross RP,Fitzgerald GF,Brodkorb A

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  • Water-in-oil-in-water double emulsions loaded with chlorogenic acid: release mechanisms and oxidative stability.

    abstract::Chlorogenic acid (CA) is a natural compound used as an antioxidant in the preparation of food, drugs, and cosmetics. Due to their low stability and bioavailability, many researchers have studied the encapsulation of CA in various delivery colloidal systems. The aim of this study was to evaluate the stability of water-...

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    authors: Dima C,Dima S

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  • Development of liposomal amphotericin B formulation.

    abstract::A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...

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    pub_type: 杂志文章,评审


    authors: Gulati M,Bajad S,Singh S,Ferdous AJ,Singh M

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    authors: Hunt GR,Jones IC

    更新日期:1984-04-01 00:00:00

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    authors: Desai NM,Gilbert Stanley J,Murthy PS

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  • Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro.

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    authors: Rubas W,Banerjea AC,Gallati H,Speiser PP,Joklik WK

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    authors: Mundargi RC,Patil SA,Kulkarni PV,Mallikarjuna NN,Aminabhavi TM

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ertan G,Karasulu E,Abou-Nada M,Tosun M,Ozer A

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    pub_type: 杂志文章


    authors: Gottschalk P,Brodesser B,Poncelet D,Jaeger H,Rennhofer H,Cole S

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    pub_type: 杂志文章


    authors: Tröster SD,Kreuter J

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Nayak B,Panda AK,Ray P,Ray AR

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    pub_type: 杂志文章


    authors: Habib M,Onyilofor S,Ebube NK,Owusu-Ababio G

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    pub_type: 杂志文章


    authors: Yoshida PA,Yokota D,Foglio MA,Rodrigues RA,Pinho SC

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    pub_type: 杂志文章


    authors: Mura P,Maestrelli F,Cecchi M,Bragagni M,Almeida A

    更新日期:2010-01-01 00:00:00

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Liu L,Yonetani T

    更新日期:1994-07-01 00:00:00