Abstract:
:One of the main challenges in radiation oncology is to overcome the resistance of cancer cells against treatment by molecular targeted approaches. Among the most promising targets is the inhibitor of apoptosis protein survivin, known to be associated with increased tumour aggressiveness and therapy resistance. The objective of this study was the development of a human serum albumin-based nanoparticulate carrier system for plasmid-mediated RNA interference (miRNA) and the investigation of its in vitro efficacy on survivin knockdown and cellular toxicity in SW480 colorectal cancer cells. The results demonstrate a robust nanoparticulate system of a size around 220 nm with a plasmid incorporation efficacy of about 90%. Moreover, treatment of carcinoma cells with survivin-miRNA nanoparticles resulted in reduction of survivin expression by 50% and increased cytotoxicity if combined with ionising irradiation. These nanoparticles comprise a promising option to enhance the response of carcinoma cells to therapy with ionising irradiation.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Gaca S,Reichert S,Rödel C,Rödel F,Kreuter Jdoi
10.3109/02652048.2012.680511subject
Has Abstractpub_date
2012-01-01 00:00:00pages
685-94issue
7eissn
0265-2048issn
1464-5246journal_volume
29pub_type
杂志文章abstract::The sorption of 5-fluorouracil from aqueous solutions onto poly(methyl methacrylate) was investigated. Linear sorption isotherms were obtained and no crystallinity of the nanoparticles after sorption was detectable by X-ray analysis indicating a partitioning of the drug into the polymer particles-forming a solid solut...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048609031560
更新日期:1986-04-01 00:00:00
abstract::Ionotropic gelation was used to entrap sulindac into calcium alginate beads as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Beads were investigated in vitro for a possible sustained drug release and their use in vivo as a gastroprotective system for sulindac. Process parameters such a...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701298153
更新日期:2007-06-01 00:00:00
abstract::We demonstrate the microencapsulation of a double-base (DB) rocket propellant stabiliser, 2-nitrodiphenylamine (2-NDPA), that can potentially increase the shelf life of DB rocket propellants. Poly(lactide-co-glycolide) (PLG) microspheres loaded with 2-NDPA were prepared using the oil-in-water emulsion technique. The m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2012.668956
更新日期:2012-01-01 00:00:00
abstract::The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1375039
更新日期:2017-11-01 00:00:00
abstract::Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009021848
更新日期:1990-07-01 00:00:00
abstract::Secretory leukocyte protease inhibitor (SLPI) is an endogenous serine protease inhibitor that protects the lungs from excessive tissue damage caused by leukocyte proteases released during inflammation. Recombinant SLPI (rSLPI) has shown potential as a treatment for inflammatory lung conditions. To date, its clinical a...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040802466535
更新日期:2009-09-01 00:00:00
abstract::Multilamellar liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.) leaves were produced by dry film hydration. Gas chromatography demonstrated the compounds found in the essential oil were effectively incorporated in the aqueous dispersions of liposomes. Differential scanning calorimetry ana...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652040903367327
更新日期:2010-01-01 00:00:00
abstract::Silica gel microspheres are ideal materials for bioencapsulation due to their mechanical properties, biocompatibility, and stability. Encapsulated cells are isolated from the environment and protected from predators, changes in pH, and osmotic stress. However methods for the production of silica gel microspheres suita...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1202346
更新日期:2016-08-01 00:00:00
abstract::Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemic...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109021856
更新日期:1991-01-01 00:00:00
abstract::Indomethacin micro-crystals sized approximately 2 microm have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on approximately 2 microm drug micro-c...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040500044972
更新日期:2005-02-01 00:00:00
abstract::Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the ente...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040010019442
更新日期:2001-05-01 00:00:00
abstract::The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulat...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701288519
更新日期:2007-08-01 00:00:00
abstract::Chronic osteomyelitis is still the cause of many problems in orthopaedics in terms of therapy and infection persistence. Four-to-six week systemic antibiotic therapy is required along with bone and soft tissue debridement in the therapy of chronic osteomyelitis. Prolonged-release local antibiotic therapy has been take...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/0265204031000154179
更新日期:2003-11-01 00:00:00
abstract::In this study, we formulated a microparticulate melanoma cancer vaccine via the transdermal route. The vaccine was delivered using microneedle-based Dermaroller® which is available for cosmetic purposes. Unlike subcutaneous injections, administration using microneedles is painless and in general can increase the perme...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.559287
更新日期:2011-01-01 00:00:00
abstract::Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048609021799
更新日期:1986-10-01 00:00:00
abstract::For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/0265204031000093096
更新日期:2003-07-01 00:00:00
abstract::The use of polymeric carriers in formulations of therapeutic drug delivery systems has gained widespread application, due to their advantage of being biodegradable and biocompatible. Among the microparticulate systems, microspheres have a special importance since it is possible to target drugs and provide controlled r...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/026520400288382
更新日期:2000-03-01 00:00:00
abstract::The mechanism by which microcapsule aggregation is diminished in the presence of low concentrations of adjunct non-walling polymers such as polyisobutylene (PIB) in organic solvents is uncertain. It is here investigated by phase separation studies employing the non-solvent addition method (cyclohexane) in parallel wit...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009028419
更新日期:1990-01-01 00:00:00
abstract::Oil-containing polyterephthalamide microcapsules were synthesized by the interfacial polymerization of an oil-soluble monomer (terephthaloyl dichloride, TDC) and a mixture of two water-soluble monomers (diethylenetriamine, DETA, and 1, 6-hexamethylenediamine, HMDA). The influence of several synthesis parameters (e.g. ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040110055243
更新日期:2001-11-01 00:00:00
abstract::The real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. In the present study, an anti-ulcer drug, ranitidine...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040801973101
更新日期:2008-08-01 00:00:00
abstract::For slow release of tea tree oil (TTO), TTO were encapsulated by urea-formaldehyde (UF) resin via in situ polymerisation. The effects of curing time and drying condition on particle size, and TTO loading of the TTO/UF microcapsules were investigated. The results indicated that TTO/UF resin microcapsules with curing ti...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1735548
更新日期:2020-06-01 00:00:00
abstract::Prototype fragrances, prepared from common fragrance components, were extracted with water, recovered, and characterized by gas chromatography before and after the water treatment, revealing a significant loss of the more water-soluble components. Unextracted prototype fragrances were also microencapsulated by a gelat...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049209021244
更新日期:1992-07-01 00:00:00
abstract::This study focuses on development and in vitro characterisation of a nasal delivery system based on uncoated or chitosan-coated solid lipid microparticles (SLMs) containing resveratrol, a natural anti-inflammatory molecule, as an effective alternative to the conventional steroidal drugs. The physico-chemical character...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1260659
更新日期:2016-12-01 00:00:00
abstract::This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1409819
更新日期:2018-01-01 00:00:00
abstract::The effects of different loading procedures of magnetic nanoparticles (MNs) on the structure and physicochemical properties of cisplatin magnetic liposomes were investigated by X-ray diffraction, infrared spectroscopy, transmission electron microscopy, and fluorescence spectroscopy. 1, 2-Dipalmitoyl-sn-glycero-3-Phosp...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2012.692397
更新日期:2012-01-01 00:00:00
abstract::The regularities of release of therapeutic antioxidant enzyme superoxide dismutase (SOD) from various alginate-based delivery systems (DS) into simulated gastric and intestinal fluids were determined. The following systems were used: Ca-alginate granules (AG) prepared by various methods, porous carbonate cores with mu...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1206146
更新日期:2016-08-01 00:00:00
abstract::The formation of microcapsules which contain rosemary oil, is herewith described. The process is based on two steps: (a) formation of oil-in-water emulsions, by using lecithin as emulsifier, thus imparting negative charges on the oil droplets; (b) addition of a cationic biopolymer, chitosan, in conditions that favor t...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049709015332
更新日期:1997-03-01 00:00:00
abstract::H-n.m.r. spectroscopy of small unilamellar phospholipid vesicles in the presence of the lanthanide probe ion Dy3+ has been used to study the permeability of these liposomes induced by the bile salts (glycocholate and glycodeoxycholate) and pancreatic phospholipase A2. A marked synergism is demonstrated in the combined...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048409038515
更新日期:1984-04-01 00:00:00
abstract::Microencapsulation is almost exclusively performed in batch processes. With today's chemistry increasingly performed in flow reactors, this work aims to realise a continuous reactor setup for the encapsulation of an ester with a polyuria (PU) shell. The generation of an emulsion template is performed in a recirculatio...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1633433
更新日期:2019-06-01 00:00:00
abstract::The present study is part of a larger project whose aim is to understand how the oyster Crassostrea gigas develops its aromas from a lipid precursor, the eicosapentaenoic acid (EPA), in glyceride form. The objective of this study is, therefore, to prepare an encapsulation process that will enable the bivalve to be sup...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00