Abstract:
:Multilamellar liposomes incorporating essential oil of Brazilian cherry (Eugenia uniflora L.) leaves were produced by dry film hydration. Gas chromatography demonstrated the compounds found in the essential oil were effectively incorporated in the aqueous dispersions of liposomes. Differential scanning calorimetry analyses revealed the incorporation of the essential oil did not cause phase separation in the membrane structure; the gel-liquid crystalline transition temperature (main transition) remained the same despite the higher heterogeneity indicated by the transition peak broadening. Different cryoprotectors (sucrose and trehalose) were added to the liposomal formulations to be tested in their ability to protect the liposomal structure during the lyophilization. The morphological aspect of the lyophilized powders analysed by scanning electron microscopy showed significant differences among the samples with and without cryoprotectors. Fourier-transform infrared spectroscopy indicated the cryoprotectors interacted effectively with the polar heads of phospholipids in the bilayer. In terms of water absorption, trehalose was identified as a much more effective protector agent against it than sucrose. The cryoprotectors showed different degrees of effectiveness of preservation of the liposomal structure when the rehydration assays of lyophilized liposomes were carried out, as particle size measurements indicated a moderate process of fusion when the formulations with sucrose were rehydrated.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Yoshida PA,Yokota D,Foglio MA,Rodrigues RA,Pinho SCdoi
10.3109/02652040903367327subject
Has Abstractpub_date
2010-01-01 00:00:00pages
416-25issue
5eissn
0265-2048issn
1464-5246journal_volume
27pub_type
杂志文章abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title:Journal of microencapsulation
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更新日期:2020-12-28 00:00:00
abstract::Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...
journal_title:Journal of microencapsulation
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abstract::Encapsulation of mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug with cationic acrylic resin, Eudragit E, was carried out using a fluidized-bed granulator (Glatt AG). Three drug:polymer ratios were prepared using 50 ml of 1, 2.5 and 5 per cent w/v aqueous suspension of Eudragit to coat 100 mg powde...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048709021807
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abstract::The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/026520499289077
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abstract::Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size ...
journal_title:Journal of microencapsulation
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abstract::Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
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更新日期:2009-02-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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更新日期:2014-01-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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更新日期:2000-09-01 00:00:00
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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更新日期:2012-01-01 00:00:00
abstract::In this study, we formulated a microparticulate melanoma cancer vaccine via the transdermal route. The vaccine was delivered using microneedle-based Dermaroller® which is available for cosmetic purposes. Unlike subcutaneous injections, administration using microneedles is painless and in general can increase the perme...
journal_title:Journal of microencapsulation
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of microencapsulation
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abstract::Liposomes are known to be a potent adjuvant for a wide range of antigens, as well as appropriate antigen carriers for antibody generation response in vivo. In addition, liposomes are effective vehicles for peptides and proteins, thus enhancing their immunogenicity. Considering these properties of liposomes and the ant...
journal_title:Journal of microencapsulation
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abstract::Drug-free polylactic acid (PLA) microspheres were prepared by an emulsification-solvent evaporation technique using different types of protective colloids. The influence of five types of hydrophilic prolymers (polysaccharides, proteins, synthetic cellulose derivatives, synthetic nonionic polymers and surfactants) on t...
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更新日期:1998-05-01 00:00:00
abstract::The chitosan microspheres were prepared by a membrane emulsification method with variations of the N2 gas pressure and the chitosan concentration. The pressure of N2 gas was varied within the range from 0.2 x 10(5) to 0.8 x 10(5) Pa at chitosan concentration 1.5 wt%. In addition, the concentration of chitosan was vari...
journal_title:Journal of microencapsulation
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更新日期:2004-08-01 00:00:00
abstract::Nanoencapsulation by spray drying was performed to protect and preserve antioxidant rich dietary polyphenols from green coffee beans. Nano-encapsulation of green coffee was done using maltodextrin as wall material. The nanoparticles were further characterised by zetasizer, differential scanning colorimetry, X-ray diff...
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abstract::The aim of the present study is to construct a type of polyion complex micelles made of PF127-PEI copolymer and cholic acid (CA) and to evaluate the potential of this type of micelles as a targeted drug delivery system for paclitaxel (PTX). To further improve the targeting capability of micelles, folate was also incor...
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