Abstract:
:Using liposomes radiolabelled by the 99mTechnetium-stannous chloride technique we have investigated the effect of surface charge on the stability of the isotope in vitro and in vivo. Dialysis of 99mTc-labelled positive, negative and neutral liposomes, which had been incubated in either saline or normal rat serum showed no significant loss of the isotope from the liposome surface with only 2 per cent of the isotope dialysed. A comparison of gel chromatography with dialysis confirmed that most of the isotope remained attached to the liposome surface, but it did reveal greater loss of the isotope, between 15 and 23 per cent. The liposome clearance rates obtained from 125I-egg phosphatidylcholine (EPC) and 99mTc dual-labelled positive or neutral liposomes were significantly different. The 99mTc marker was cleared five times faster from the positive liposomes and twice as fast from the neutral liposomes as the 125I-EPC integral membrane marker. The 99mTc attached to liposomes with a negative surface charge was stable in vivo and had the same clearance rate from the circulation as the 125I-EPC marker. These results indicate that the commonly used in vitro techniques for assessing liposome radiolabel stability are unsuitable for predicting the stability of the 99mTc in vivo.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Love WG,Amos N,Williams BD,Kellaway IWdoi
10.3109/02652048909019907subject
Has Abstractpub_date
1989-01-01 00:00:00pages
105-13issue
1eissn
0265-2048issn
1464-5246journal_volume
6pub_type
杂志文章abstract::The present research work was aimed at development and optimization of alginate mucoadhesive microspheres of carvedilol for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres were prepared by a water-in-oil (w/o) ...
journal_title:Journal of microencapsulation
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abstract::The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulat...
journal_title:Journal of microencapsulation
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doi:10.1080/02652040701288519
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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doi:10.1080/026520400288382
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abstract::Low molecular weight heparin (LMWH)-loaded flexible liposomes (flexosomes) were formulated for transdermal delivery, and their physicochemical and pharmacokinetic parameters were compared with LMWH-loaded ethosomes. Flexosomes had similar particle size compared with ethosomes, but their deformability was higher than t...
journal_title:Journal of microencapsulation
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abstract::Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...
journal_title:Journal of microencapsulation
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doi:10.3109/02652049009021848
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040210140472
更新日期:2002-09-01 00:00:00
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049709033835
更新日期:1997-07-01 00:00:00
abstract::Monodisperse albumin microspheres were successfully prepared by both chemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersity of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier c...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049809008248
更新日期:1998-09-01 00:00:00
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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doi:10.3109/02652049609026029
更新日期:1996-07-01 00:00:00
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journal_title:Journal of microencapsulation
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doi:
更新日期:2003-03-01 00:00:00
abstract::Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size ...
journal_title:Journal of microencapsulation
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doi:10.1080/02652048.2019.1656294
更新日期:2019-09-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2015.1035683
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Quercetin (QUE) is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when orally administered. OBJECTIVES:To prepare chitosan/xanthan gum microparticles to increase QUE oral bioavailability and optimize its release in the colon. MATERIALS AND METHODS:Chitosan/xanthan gum hydrogel embe...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.913726
更新日期:2014-01-01 00:00:00
abstract::Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the ente...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040010019442
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009021838
更新日期:1990-04-01 00:00:00
abstract::Catechin (CT) is natural molecule proved for antidiabetic activity. Clinical application of CT is highly restricted because of its low bioavailability and ineffectiveness in in vivo conditions. Therefore, the main objective of the present investigation was to formulate CT-loaded Eudragit RS 100 microparticles and eval...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1337248
更新日期:2017-06-01 00:00:00
abstract:AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were com...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2014.913724
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.651498
更新日期:2012-01-01 00:00:00
abstract::A novel method for preparing the PLGA nanospheres with hydrophilic surface has been designed and characterized. Because of good solubility of tetraglycol in water, PLGA (poly(lactide-co-glycolide)) nanospheres were formed by spraying the PLGA/tetraglycol solution into water. The size of PLGA nanospheres was manipulate...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040400000520
更新日期:2004-11-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040500435436
更新日期:2006-02-01 00:00:00
abstract::Solid lipid nanoparticles (SLNs) and nanosuspensions (NSs) have shown great promise for improving bioavailability of poorly water-soluble drugs. This study was aimed to develop SLNs and NS of Saquinavir (SQ) for improvement in bioavailability. These formulations were characterized and their pharmacokinetics and biodis...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.590612
更新日期:2011-01-01 00:00:00