Solid lipid nanoparticles and nanosuspension formulation of Saquinavir: preparation, characterization, pharmacokinetics and biodistribution studies.

abstract：:The blood-brain barrier (BBB) is the major problem for the treatment of central nervous system diseases. A previous study from our group showed that the brain-targeted chitosan nanoparticles-loaded with large peptide moieties can rapidly cross the barrier and provide neuroprotection. The present study aims to determin...

journal_title：Journal of microencapsulation

authors： Sahin A,Yoyen-Ermis D,Caban-Toktas S,Horzum U,Aktas Y,Couvreur P,Esendagli G,Capan Y

更新日期：2017-11-01 00:00:00

abstract：:Using formalin inactivated Actinobacillus pleuropneumoniae antigens and aqueous ethylcellulose dispersions, microspheres of oral vaccines were developed by a co-spray drying process. The present study attempted to determine whether the dosage formulations of microspheres could form enteric matrices. To assess the ente...

journal_title：Journal of microencapsulation

authors： Liao CW,Cheng IC,Yeh KS,Lin FY,Weng CN

更新日期：2001-05-01 00:00:00

abstract：:The aim of this study was to investigate how glass transition temperature (Tg) influenced polymer microsphere formation and degradation of three chemically, similar novel salicylatebased poly(anhydride-esters): poly[1,6-bis(o-carboxyphenoxy)hexanoate] (CPH), Tg = 59 degrees C; poly[1,8-bis(o-carboxyphenoxy)octanoate] ...

journal_title：Journal of microencapsulation

authors： Yeagy BA,Prudencio A,Schmeltzer RC,Uhrich KE,Cook TJ

更新日期：2006-09-01 00:00:00

abstract：:A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...

journal_title：Journal of microencapsulation

authors： Gulati M,Bajad S,Singh S,Ferdous AJ,Singh M

更新日期：1998-03-01 00:00:00

abstract：:The factors influencing the encapsulation of azathioprine (AZA) into liposomes were investigated to find out the conditions for its optimal entrapment. Similar studies for comparison were also carried out on 6-mercaptopurine (6-MP), of which AZA is a prodrug. AZA and also 6-MP show higher encapsulation efficiencies in...

journal_title：Journal of microencapsulation

authors： Gulati M,Grover M,Singh M,Singh S

更新日期：1998-07-01 00:00:00

abstract：:Prototype fragrances, prepared from common fragrance components, were extracted with water, recovered, and characterized by gas chromatography before and after the water treatment, revealing a significant loss of the more water-soluble components. Unextracted prototype fragrances were also microencapsulated by a gelat...

journal_title：Journal of microencapsulation

authors： Flores RJ,Wall MD,Carnahan DW,Orofino TA

更新日期：1992-07-01 00:00:00

abstract：:This paper discusses the optimization of the solvent evaporation process to produce double-walled (DW) microspheres in a single-step. Five process variables were studied: polymer solution concentration, polymer weight ratio, polymer solution volume ratios, encapsulation temperature, and air flow rate across the top of...

journal_title：Journal of microencapsulation

authors： Leach K,Noh K,Mathiowitz E

更新日期：1999-03-01 00:00:00

abstract：:The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...

journal_title：Journal of microencapsulation

authors： Ustariz-Peyret C,Coudane J,Vert M,Kaltsatos V,Boisramené B

更新日期：2000-09-01 00:00:00

abstract：:Water-in-oil-in-water multiple emulsions of chloroquine diphosphate were prepared, using olive oil, arachis oil, Span 80, gelatin, acacia and Tween 80. Emulsifiers were employed individually or in combination. An attempt was made to correlate preparative variables with stability and drug release of multiple emulsions ...

journal_title：Journal of microencapsulation

authors： Vaziri A,Warburton B

更新日期：1994-11-01 00:00:00

abstract：:Co-flowing media of a polymeric solution (30 wt% polymethylsilsesquioxane in ethanol) and a ceramic suspension (10 wt% alumina in glycerol) were subjected to an electric field. The flow rates of the media (10-30 microL min(-1)) and the applied voltage (0-11 kV) were varied systematically during the experimentation by ...

journal_title：Journal of microencapsulation

authors： Nangrejo M,Ahmad Z,Edirisinghe M

更新日期：2010-01-01 00:00:00

abstract：:Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...

journal_title：Journal of microencapsulation

authors： Ming Y,Hu J,Xing J,Wu M,Qu J

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:Naproxen CR tablets have been obtained from its microspheres prepared by coprecipitation with Eudragit L100-55. The purpose of this work was to evaluate the main and interaction effects of deaggregating agent concentration (X1), compression pressure (X2) and amount of precipitating water (X3) on naproxen releas...

journal_title：Journal of microencapsulation

authors： Zaghloul AA,Vaithiyalingam SR,Faltinek J,Reddy IK,Khan MA

更新日期：2001-09-01 00:00:00

abstract：:Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size ...

journal_title：Journal of microencapsulation

authors： Wang B,Cheng W,Zhang C,Bao Y,Zha L,Qian J,Hong L,Chen W

更新日期：2019-09-01 00:00:00

abstract：:Magnetic and pH-responsive chitosan microcapsules (MPRCMCs) were prepared by a simple sonochemical method. Superparamagnetic oleic acid modified Fe3O4 nanoparticles (OA-Fe3O4 NPs) and hydrophobic drugs could be directly loaded into MPRCMCs during sonication. The obtained microcapsules had a well-defined spherical morp...

journal_title：Journal of microencapsulation

authors： Xu F,Zhao T,Wang S,Liu S,Yang T,Li Z,Wang H,Cui X

更新日期：2016-01-01 00:00:00

abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...

journal_title：Journal of microencapsulation

authors： Kiyoyama S,Shiomori K,Kawano Y,Hatate Y

更新日期：2003-07-01 00:00:00

abstract：:This study demonstrates the feasibility of using a single-capillary electrospray (ES) system to generate novel alpha-lipoic acid encapsulated poly(ethylene oxide)-chitosan (ALA/PEO/CS) particles with a monodispersed diameter. Scanning electron microscopic images (SEM) and dynamic light scattering (DLS) results indicat...

journal_title：Journal of microencapsulation

authors： Bai MY,Hu YM

更新日期：2014-01-01 00:00:00

abstract：:The present research work was aimed at development and optimization of alginate mucoadhesive microspheres of carvedilol for nasal delivery to avoid first pass metabolism and to improve the therapeutic efficacy in the treatment of hypertension and angina pectoris. The microspheres were prepared by a water-in-oil (w/o) ...

journal_title：Journal of microencapsulation

authors： Patil SB,Sawant KK

更新日期：2009-08-01 00:00:00

abstract：:The in vivo absorption of crystalline nitrofurantoin and the dosage forms of nitrofurantoin prepared with microcapsules were carried out in man by determination of urinary excretion of unchanged nitrofurantoin. The cumulative amount of drug excreted and the duration of the therapeutic urine levels were compared. The m...

journal_title：Journal of microencapsulation

authors： Ertan G,Karasulu E,Abou-Nada M,Tosun M,Ozer A

更新日期：1994-03-01 00:00:00

abstract：:Catechin (CT) is natural molecule proved for antidiabetic activity. Clinical application of CT is highly restricted because of its low bioavailability and ineffectiveness in in vivo conditions. Therefore, the main objective of the present investigation was to formulate CT-loaded Eudragit RS 100 microparticles and eval...

journal_title：Journal of microencapsulation

authors： Meena KP,Vijayakumar MR,Dwibedy PS

更新日期：2017-06-01 00:00:00

abstract：:To improve poor water solubility of cyclosporine A (CsA), hydroxypropyl-beta-cyclodextrin (HPβCD) was incorporated into the nanoparticle formulation. Solid complexes of CsA with HPβCD in different ratios were prepared by the kneading method. CsA containing alone or in combination with HPβCD in poly-lactide-co-glycolid...

journal_title：Journal of microencapsulation

authors： Aksungur P,Demirbilek M,Denkbaş EB,Unlü N

更新日期：2012-01-01 00:00:00

abstract：:Using liposomes radiolabelled by the 99mTechnetium-stannous chloride technique we have investigated the effect of surface charge on the stability of the isotope in vitro and in vivo. Dialysis of 99mTc-labelled positive, negative and neutral liposomes, which had been incubated in either saline or normal rat serum showe...

journal_title：Journal of microencapsulation

authors： Love WG,Amos N,Williams BD,Kellaway IW

更新日期：1989-01-01 00:00:00

abstract：:In this study microspheres of diclofenac sodium, an anti-inflammatory agent, were prepared by utilizing a natural polysaccharide, chitosan-H. The objective of this investigation was to sustain the action of diclofenac sodium and to show the effect of various conditions on release kinetics. For this reason factorial de...

journal_title：Journal of microencapsulation

authors： Açikgöz M,Kaş HS,Orman M,Hincal AA

更新日期：1996-03-01 00:00:00

abstract：:Artificial chylomicron remnants were investigated as a new drug carrier system for the targeting of hepatic parenchymal cells. The emulsions presented here are similar in particle size and composition to natural lipoproteins. The preparations contained triolein, phospholipid, cholesterol and cholesteryl oleate. Egg yo...

journal_title：Journal of microencapsulation

authors： Vuaridel-Bonanomi ES,Weder HG

更新日期：1991-04-01 00:00:00

abstract：:The aim of the present study is to construct a type of polyion complex micelles made of PF127-PEI copolymer and cholic acid (CA) and to evaluate the potential of this type of micelles as a targeted drug delivery system for paclitaxel (PTX). To further improve the targeting capability of micelles, folate was also incor...

journal_title：Journal of microencapsulation

authors： Li Y,Zhou Y,De B,Li L

更新日期：2014-01-01 00:00:00

abstract：:Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...

journal_title：Journal of microencapsulation

authors： Wang DW,Zhao XP

更新日期：2009-02-01 00:00:00

abstract：:Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release...

journal_title：Journal of microencapsulation

authors： Sheorey DS,Dorle AK

更新日期：1994-01-01 00:00:00

abstract：:Chitosan microspheres were prepared by an emulsion-phase separation technique without the use of chemical cross-linking agents; alternatively, ionotropic gelation was employed in a w/o emulsion. The possibility of three kinds of anions (tripolyphosphate, citrate and sulphate) to interact with chitosan was investigated...

journal_title：Journal of microencapsulation

authors： Shu XZ,Zhu KJ

更新日期：2001-03-01 00:00:00

abstract：:Polylactide (PLA) and polylactide-co-glycolide (PLGA) particles entrapping rotavirus (strain SA11) were formulated using a solvent evaporation technique. To minimize denaturation of viral antigen during the emulsification process, serum albumin was used as a stabilizer. Use of NaHCO(3) and sucrose during the primary e...

journal_title：Journal of microencapsulation

authors： Nayak B,Panda AK,Ray P,Ray AR

更新日期：2009-03-01 00:00:00

abstract：:Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...

journal_title：Journal of microencapsulation

authors： Goto S,Kawata M,Nakamura M,Maekawa K,Aoyama T

更新日期：1986-10-01 00:00:00

abstract：:Aims: The study was carried out to synthesise and characterise the chitosan-encapsulated genistein (CHI-En/Gen) and determine its anti-cancer and anti-angiogenic properties.Methods: The cytotoxic and anti-angiogenic activity of CHI-En/Gen was performed using MTT and chorioallantoic membrane assay. The molecular action...

journal_title：Journal of microencapsulation

authors： Rahmani F,Karimi E,Oskoueian E

更新日期：2020-06-01 00:00:00