Abstract：
:Water-in-oil-in-water multiple emulsions of chloroquine diphosphate were prepared, using olive oil, arachis oil, Span 80, gelatin, acacia and Tween 80. Emulsifiers were employed individually or in combination. An attempt was made to correlate preparative variables with stability and drug release of multiple emulsions of roughly comparative particle size. When the emulsions were satisfactorily stabilized by the optimum blend of surfactants the rate of release varied with the nature and/or combination of emulsifiers employed. The possible effects of phase-inversion temperature, spontaneous emulsification and liquid crystal stabilization on the systems have been discussed. The mechanism probably involved complex interfacial adsorption and hydrodynamic phenomena in the presence of natural oils, co-surfactants and natural stabilizers of individual HLB number, particularly when acacia is present in the system. This could be attributed to the existence of protein in some species of acacia, since there are about 130 species of acacia, the gummy exudations of which are considered official in compendia. The protein content could be a reasonable additional specification for acacia as an emulsifier.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Vaziri A,Warburton Bdoi
10.3109/02652049409051115subject
Has Abstractpub_date
1994-11-01 00:00:00pages
649-56issue
6eissn
0265-2048issn
1464-5246journal_volume
11pub_type
杂志文章abstract：:The aim of the present study is to construct a type of polyion complex micelles made of PF127-PEI copolymer and cholic acid (CA) and to evaluate the potential of this type of micelles as a targeted drug delivery system for paclitaxel (PTX). To further improve the targeting capability of micelles, folate was also incor...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.940010
更新日期：2014-01-01 00:00:00
abstract：:For the preparation of microcapsules using the W/O/W (water in oil in water) emulsion system, it is essential to control various factors such as the dispersed state of the organic phase in the W/O/W emulsion, the difference in the solute concentration between the inner and outer aqueous phases and the volume fraction ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/0265204031000093096
更新日期：2003-07-01 00:00:00
abstract：:The aim of this study was to design and develop microspheres of indomethacin with pH and transit time dependent release properties for achieving targeted delivery to the colon. Microspheres containing varying proportions of ethyl cellulose and Eudragit (L100 or S100) either alone or in combination were prepared using ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802424021
更新日期：2009-08-01 00:00:00
abstract：:The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-water (w/o/w) double emulsions, containing salbutamol sulphate and/or be...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040903052044
更新日期：2010-01-01 00:00:00
abstract：:The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520400417667
更新日期：2000-09-01 00:00:00
abstract：:Microencapsulation of ketoprofen using Eudragit RS and RL (acrylic resins) was investigated based on the dispersion system of ketoprofen-containing acetone in liquid paraffin. Aluminium tristearate was used as an additive for the preparation of microcapsules. Good reproducibility was observed in the microencapsulation...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048609021799
更新日期：1986-10-01 00:00:00
abstract：:A biocompatible emulsification method has been developed for microencapsulation of live cells and enzymes within a calcium alginate matrix. Fabrication of alginate beads was achieved by premixing a sequestering agent (sodium polyphosphate) and the calcium source (calcium sulphate) with the hydrogel monomer prior to th...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049509010294
更新日期：1995-05-01 00:00:00
abstract：:Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040802127806
更新日期：2009-02-01 00:00:00
abstract：:An extrusion-based encapsulation process has been developed for making salt grain-sized iron premix for salt fortification. The first step of extrusion agglomeration process has been studied and reported previously. The focus of this study is on the optimisation of the colour-masking and polymer coating steps. Several...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.651493
更新日期：2012-01-01 00:00:00
abstract：:The effect of lecithin and starch on viability of alginate encapsulated probiotics was determined at different temperatures. Probiotic organisms (1% v/v>10Log CFU ml(-1)) were encapsulated using alginate (2% w/v), gelatinized starches (2% w/v) and lecithin (0-4% w/v) and stored in sealed containers at 4, 23 and 37 deg...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040902982183
更新日期：2010-01-01 00:00:00
abstract：:The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing s...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652040802685241
更新日期：2009-12-01 00:00:00
abstract：:Protamine-oligonucleotide nanoparticles represent effective colloidal drug carriers for antisense phosphorothioate oligonucleotides (PTO). This study describes improvements in particle preparation and the physicochemical properties of the complexes prepared. The influence of component concentrations, length of the PTO...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040400000504
更新日期：2004-09-01 00:00:00
abstract：:Aims: The study was carried out to synthesise and characterise the chitosan-encapsulated genistein (CHI-En/Gen) and determine its anti-cancer and anti-angiogenic properties.Methods: The cytotoxic and anti-angiogenic activity of CHI-En/Gen was performed using MTT and chorioallantoic membrane assay. The molecular action...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2020.1740804
更新日期：2020-06-01 00:00:00
abstract：:Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009021848
更新日期：1990-07-01 00:00:00
abstract：:A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment f...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040110055225
更新日期：2002-11-01 00:00:00
abstract：:The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied. The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism. Micro-pellets produced were sieved into several fractions and...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040500100345
更新日期：2005-05-01 00:00:00
abstract：:In ophthalmic drug delivery, a major problem is retaining an adequate concentration of a therapeutic agent in the pre-corneal area. Polycarboxylic acid carriers such as polyacrylic acid and polyitaconic acid in sub-colloidal, nanoparticulate hydrogel form have a strong potential for sustained release of a drug in ocul...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040400008515
更新日期：2004-12-01 00:00:00
abstract：:Liposomes were introduced first in 1980 for topical drug delivery and since then have attracted considerable interest and generated many speculative claims concerning their potential utility both as a drug carrier and reservoir for controlled release of drugs within various layers of the skin. A number of clinical stu...
journal_title：Journal of microencapsulation
pub_type： 杂志文章,评审
doi：10.3109/02652049309104381
更新日期：1993-04-01 00:00:00
abstract：:Captopril microcapsules were prepared using four different viscosity grades of ethyl cellulose (core: wall ratios 1:1, 1:2 and 1:3) by temperature induced coacervation from cyclohexane. In vitro dissolution studies in 0.1 M hydrochloric acid showed that the drug release was dependent on the core to wall ratio, the vis...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049009028424
更新日期：1990-01-01 00:00:00
abstract：:Eudragit RS microspheres containing verapamil HCl for oral use were prepared using three different dispersing agents: aluminium tristearate, magnesium stearate and sucrose stearate, by a solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040310001637893
更新日期：2004-03-01 00:00:00
abstract：:The objective of this study was to prepare floating theophylline microspheres with zero order release profiles for use as buoyant reservoirs with increased retention time in the stomach. The microspheres were prepared by a modified emulsion-solvent evaporation method using a polymer mixture of cellulose acetate butyra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049809008255
更新日期：1998-11-01 00:00:00
abstract：AIM:To study the effect of poly(d,l-lactic-co-glycolic acid) (PLGA) microparticles (MPs) preparation techniques on particle physical characterization with special emphasis on burst drug release. METHODS:A basic drug clozapine was used in combination with acid-terminated PLGA. Two approaches for MP preparation were com...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.913724
更新日期：2014-01-01 00:00:00
abstract：CONTEXT:Solid lipid nanoparticles (SLNs) can efficiently and efficaciously incorporate anti-cancer agents. OBJECTIVE:To prepare and characterise tamoxifen (TAM)-loaded SLNs. MATERIALS AND METHODS:Glyceryl monostearate, Tween-80, and trehalose were used in SLNs. SLNs were tested via dynamic light scattering (DLS), tra...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2014.898707
更新日期：2014-01-01 00:00:00
abstract：:Transplantation of cells genetically modified to produce neurotrophins is a promising spinal cord repair strategy. Previously we showed that fibroblasts engineered to produce brain-derived neurotrophic factor (Fb/BDNF) microencapsulated in alginate survive, continue to grow and express bioactive BDNF. We here compared...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652048.2011.569765
更新日期：2011-01-01 00:00:00
abstract：:Regular spherical microspheres of 220-260 microns average size have been prepared from vinylpyrrolidone/vinylacetate copolymer using a solvent evaporation method. Griseofulvin has been incorporated into these microspheres and its physical characterization has been carried out by differential scanning calorimetry (DSC)...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049309015315
更新日期：1993-01-01 00:00:00
abstract：:Insulin-loaded solid lipid nanoparticles (SLN), obtained by the solvent-in-water emulsion-diffusion technique, were produced using isovaleric acid (IVA) as organic phase, glyceryl mono-stearate (GMS) as lipid, soy lecithin and sodium taurodeoxycholate (TDC) as emulsifiers. IVA, a partially water-miscible solvent with ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701532981
更新日期：2007-11-01 00:00:00
abstract：:This work aimed to investigate the potential effect of cyclodextrin encapsulation on intrinsic ability of daidzein (DAD) and genistein (GEN) to inhibit the glycosaminoglycan (GAG) synthesis in fibroblasts originating from patients with mucopolysaccharidosis (MPS), type II and III. DAD or GEN encapsulation with either ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652048.2017.1409819
更新日期：2018-01-01 00:00:00
abstract：:Conditions of microencapsulation by in situ polycondensation, using melamine-formaldehyde as wall material, are influenced by the chemical nature of the core to encapsulate. In our study concerning the encapsulation of a photopolymerizable phase containing an electrically charged compound, it was necessary to modify t...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.3109/02652049309031522
更新日期：1993-07-01 00:00:00
abstract：:The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulat...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/02652040701288519
更新日期：2007-08-01 00:00:00
abstract：:The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administ...
journal_title：Journal of microencapsulation
pub_type： 杂志文章
doi：10.1080/026520499289077
更新日期：1999-05-01 00:00:00
