Effect of different dispersing agents on the characteristics of Eudragit microspheres prepared by a solvent evaporation method.

Abstract:

:Eudragit RS microspheres containing verapamil HCl for oral use were prepared using three different dispersing agents: aluminium tristearate, magnesium stearate and sucrose stearate, by a solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentration on the size and T63.2%, (the time at which 63.2% of the drug is released) of microspheres were determined by multiple linear regression analysis. The morphology of microspheres was characterized by scanning electron microscopy. The surface of microspheres prepared with sucrose stearate was smoother and non-porous and the drug release from these microspheres was the fastest. When aluminium tristearate or magnesium stearate were used as dispersing agents, the particle size of microspheres became smaller. Increasing amounts of these two dispersing agents led to the accumulation of their free particles onto the surfaces of the microspheres. The drug release from the microspheres was slower than that of the microspheres from sucrose stearate depending on their hydrophobic structures. According to the results of the multiple linear regression analysis among the dispersing agents used, aluminium tristearate showed the best correlation between the examined input (dispersing agent and polymer concentrations) and output (T63.2%. and particle size) variables.

journal_name

J Microencapsul

authors

Horoz BB,Kiliçarslan M,Yüksel N,Baykara T

doi

10.1080/02652040310001637893

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

191-202

issue

2

eissn

0265-2048

issn

1464-5246

pii

AT3F3AMP4DCRDF0T

journal_volume

21

pub_type

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