Abstract:
:PLA microparticles containing 17-β-estradiol valerate were prepared by an emulsion/evaporation method in order to sustain drug release. This system was characterized concerning particle size, particle morphology and the influence of formulation and processing parameters on drug encapsulation and in vitro drug release. The biodegradation of the microparticles was observed by tissue histological analysis. Scanning electron microscopy and particle size analysis showed that the microparticles were spherical, presenting non-aggregated homogeneous surface and had diameters in the range of 718-880 nm (inert micro-particles) and 3-4 µm (drug loaded microparticles). The encapsulation efficiency was ∼80%. Hormone released from microparticles was sustained. An in vivo degradation experiment confirmed that microparticles are biodegradable. The preparation method was shown to be suitable, since the morphological characteristics and efficiency yield were satisfactory. Thus, the method of developed microparticles seems to be a promising system for sustained release of 17-β-estradiol.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Machado SR,Lunardi LO,Tristão AP,Marchetti JMdoi
10.1080/02652040802233786subject
Has Abstractpub_date
2009-05-01 00:00:00pages
202-13issue
3eissn
0265-2048issn
1464-5246pii
904594834journal_volume
26pub_type
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journal_title:Journal of microencapsulation
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更新日期:1996-11-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1985-04-01 00:00:00
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