Preparation and characterization of D, L-PLA loaded 17-β-Estradiol valerate by emulsion/evaporation methods.

Abstract:

:PLA microparticles containing 17-β-estradiol valerate were prepared by an emulsion/evaporation method in order to sustain drug release. This system was characterized concerning particle size, particle morphology and the influence of formulation and processing parameters on drug encapsulation and in vitro drug release. The biodegradation of the microparticles was observed by tissue histological analysis. Scanning electron microscopy and particle size analysis showed that the microparticles were spherical, presenting non-aggregated homogeneous surface and had diameters in the range of 718-880 nm (inert micro-particles) and 3-4 µm (drug loaded microparticles). The encapsulation efficiency was ∼80%. Hormone released from microparticles was sustained. An in vivo degradation experiment confirmed that microparticles are biodegradable. The preparation method was shown to be suitable, since the morphological characteristics and efficiency yield were satisfactory. Thus, the method of developed microparticles seems to be a promising system for sustained release of 17-β-estradiol.

journal_name

J Microencapsul

authors

Machado SR,Lunardi LO,Tristão AP,Marchetti JM

doi

10.1080/02652040802233786

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

202-13

issue

3

eissn

0265-2048

issn

1464-5246

pii

904594834

journal_volume

26

pub_type

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