Liposomes and lipopolymeric carriers for gene delivery.

Abstract:

:In this work we have examined the ability of various lipopolyplexes to deliver genes into liver cancer cells. We evaluated different parameters such as the protocol of preparation, the lipid/DNA molar ratio, and the molecular weight and type of PEI, to optimize the formulation to achieve high transfection activity. Our hypothesis was that the association of PEI with cationic liposomes (lipopolyplexes) would increase luciferase expression compared to lipoplexes (cationic lipid and DNA) and polyplexes (cationic polymer and DNA) alone.

journal_name

J Microencapsul

authors

Tros de Ilarduya C,García L,Düzgünes N

doi

10.3109/02652048.2010.501396

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

602-8

issue

7

eissn

0265-2048

issn

1464-5246

journal_volume

27

pub_type

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