Abstract：
:The aim of this study was to formulate, characterise and evaluate the activity of amodiaquine microparticles against Leishmania donovani. Microparticles were formulated by encapsulating the drug in bovine serum albumin using the spray-dryer method. The microparticles were evaluated for size, zeta potential, drug content, encapsulation efficiency and in vitro release profile. The size range of the microparticles formulated was between 1.9 and 10 μm with an average zeta potential of -25.5 mV. Of the expected 20% drug loading, an average of 18.27% was obtained giving an encapsulation efficiency of 91.35%. Pharmacokinetic profile of amodiaquine improved with microencapsulation of the drug with Cmax, AUC0→48 and t1//2 all significantly higher than amodiaquine solution. Amodiaquine microparticles showed an overall higher bioavailability and hence were more effective in eliminating intra-tissue parasites than the drug solution. It would therefore be expected that the formulated microparticles will be more effective in treating visceral leishmaniasis.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Nettey H,Allotey-Babington GL,Somuah I,Banga NB,Afrane B,Amponsah SK,Annor H,Darko H,Hanson K,Aidoo A,Broni MN,Sasu C,Nyarko Adoi
10.1080/02652048.2017.1280094subject
Has Abstractpub_date
2017-02-01 00:00:00pages
21-28issue
1eissn
0265-2048issn
1464-5246journal_volume
34pub_type
杂志文章abstract：:The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive propertie...
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journal_title：Journal of microencapsulation
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journal_title：Journal of microencapsulation
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