Liquid phase coating to produce controlled-release alginate microspheres.


:This study explored a liquid phase coating technique to produce polymethyl methacrylate (PMMA)-coated alginate microspheres. Alginate microspheres with a mean diameter of 85.6 microm were prepared using an emulsification method. The alginate microspheres, as cores, were then coated with different types of PMMA by a liquid phase coating technique. The release characteristics of these coated microspheres in simulated gastric (SGF) and intestinal (SIF) fluids and the influence of drug load on encapsulation efficiency were studied. The release of paracetamol, as a model hydrophilic drug, from the coated microspheres in SGF and SIF was greatly retarded. Release rates of Eudragit RS100-coated microspheres in SGF and SIF were similar as the rate-controlling polymer coat was insoluble in both media. Drug release from Eudragit S100-coated microspheres was more sustained in SGF than in SIF, due to the greater solubility of the coating polymer in media with pH greater than 7.0. The drug release rate was affected by the core:coat ratio. Drug release from the coated microspheres was best described by the Higuchi's square root model. The liquid phase coating technique developed offers an efficient method of coating small microspheres with markedly reduced drug loss and possible controlled drug release.


J Microencapsul


Chan LW,Liu X,Heng PW




Has Abstract


2005-12-01 00:00:00














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    abstract::This study optimized and evaluated the conditions for surface coating of microspheres using a spray-dryer. Four formulations of Bromophenol blue (BPB)-loaded albumin microspheres were prepared using a spray-dryer, cross-linked at different concentrations and time periods. One of the optimized formulations with the des...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Bejugam NK,Uddin AN,Gayakwad SG,D'Souza MJ

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  • Development of liposomal amphotericin B formulation.

    abstract::A considerable effort has been spent in the past three decades to investigate various aspects of liposomes as novel drug delivery systems. In 1990, the first amphotericin B (AmB) liposomal preparation (L-AmB) under the brand name AmBisome was introduced into the market by Vestar. The successful marketing of the produc...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章,评审


    authors: Gulati M,Bajad S,Singh S,Ferdous AJ,Singh M

    更新日期:1998-03-01 00:00:00

  • Encapsulation and stability of clofazimine liposomes.

    abstract::The entrapment of clofazimine (CLO) in a liposomal delivery system for topical application can protect it from absorption into the blood circulation and increase its residence time within the skin. This may reduce the very long mean period of leprosy treatment, as well as the side effects due to the long term administ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Patel VB,Misra AN

    更新日期:1999-05-01 00:00:00

  • Formulation and evaluation of vinylpyrrolidone/vinylacetate copolymer microspheres with griseofulvin.

    abstract::Regular spherical microspheres of 220-260 microns average size have been prepared from vinylpyrrolidone/vinylacetate copolymer using a solvent evaporation method. Griseofulvin has been incorporated into these microspheres and its physical characterization has been carried out by differential scanning calorimetry (DSC)...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Vojnovic D,Rubessa F,Bogataj M,Mrhar A

    更新日期:1993-01-01 00:00:00

  • Preparation and in vitro evaluation of thiolated chitosan microparticles.

    abstract::The objective of this study was to prepare a microparticulate drug delivery system being based on a new thiomer, namely a chitosan 2-iminothiolane conjugate (chitosan-TBA conjugate). Due to thiol groups being immobilized on chitosan, chitosan-TBA conjugate exhibits improved mucoadhesive and permeation enhancing proper...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Maculotti K,Genta I,Perugini P,Imam M,Bernkop-Schnürch A,Pavanetto F

    更新日期:2005-08-01 00:00:00

  • Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers.

    abstract::Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Wang L,Ma Y,Gu Y,Liu Y,Zhao J,Yan B,Wang Y

    更新日期:2018-05-01 00:00:00

  • Incorporation of the reovirus M cell attachment protein into small unilamellar vesicles: incorporation efficiency and binding capability to L929 cells in vitro.

    abstract::Neutral phosphatidylcholine/cholesterol (10 : 3) liposomes with the reovirus M cell attachment protein sigma 1 were made by means of detergent dialysis method. An immunological evaluation method revealed an incorporation efficiency (pg protein/microgram lipid) of 314. Binding studies with mouse fibroblasts (L929 cells...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Rubas W,Banerjea AC,Gallati H,Speiser PP,Joklik WK

    更新日期:1990-07-01 00:00:00

  • Oxprenolol release from bioadhesive gelatin/poly(acrylic acid) microspheres.

    abstract::Drug release from gelatin/poly(acrylic acid) oxprenolol-loaded microspheres has been evaluated using an in situ sink immersion method and a wetting method. The kinetics of drug release were analysed by applying the empirical exponential equation and by the calculation of the approximate contribution of the diffusional...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Leucuta SE,Ponchel G,Duchêne D

    更新日期:1997-07-01 00:00:00

  • Nifedipine encapsulated core-shell type nanoparticles based on poly(gamma-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers.

    abstract::The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was sl...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Jeong YI,Sun HS,Shim YH,Kim C,Park SH,Choi KC,Cho CS

    更新日期:2004-06-01 00:00:00

  • Studies on the transport pathway of PBCA nanoparticles in ocular tissues.

    abstract::The transport pathway of PBCA nanoparticles through the rabbit cornea and conjunctiva was studied using fluorescence microscopy. Nanoparticles were produced by an emulsion-polymerization process, purified by a GPC procedure, and labelled with rhodamine 6G or propidium iodide as fluorescent laser dyes. The stability of...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Zimmer A,Kreuter J,Robinson JR

    更新日期:1991-10-01 00:00:00

  • Preparation of TTO/UF resin microcapsule via in situ polymerisation and modelling of its slow release.

    abstract::For slow release of tea tree oil (TTO), TTO were encapsulated by urea-formaldehyde (UF) resin via in situ polymerisation. The effects of curing time and drying condition on particle size, and TTO loading of the TTO/UF microcapsules were investigated. The results indicated that TTO/UF resin microcapsules with curing ti...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Huang Q,Gong S,Han W,Chen Y,Shu X

    更新日期:2020-06-01 00:00:00

  • Preparation and characterization of ofloxacin microspheres for the eradication of bone associated bacterial biofilm.

    abstract::Biodegradable polymers for localized delivery of antibiotics have emerged as an important approach to treating orthopaedic infections. In chronic forms of osteomyelitis which are thought to be associated with bacterial biofilm, localized delivery of a suitable antibiotic is desirable. This paper describes the formulat...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Habib M,Onyilofor S,Ebube NK,Owusu-Ababio G

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  • Effects of tremella-alginate-liposome encapsulation on oral delivery of inactivated H5N3 vaccine.

    abstract::In this study, we evaluated a system for oral vaccine delivery, consisting of liposomes coated first with a layer of tremella and then with an outer layer of acid-induced alginate. In vitro release studies showed that the triple layer of alginate-tremella-liposomes was more resistant to an acidic pH and modulated the ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Cheng HC,Chang CY,Hsieh FI,Yeh JJ,Chien MY,Pan RN,Deng MC,Liu DZ

    更新日期:2011-01-01 00:00:00

  • Effect of manufacturing conditions on the formation of double-walled polymer microspheres.

    abstract::This paper discusses the optimization of the solvent evaporation process to produce double-walled (DW) microspheres in a single-step. Five process variables were studied: polymer solution concentration, polymer weight ratio, polymer solution volume ratios, encapsulation temperature, and air flow rate across the top of...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Leach K,Noh K,Mathiowitz E

    更新日期:1999-03-01 00:00:00

  • Effect of manufacturing parameters on the characteristics of vitamin C encapsulated tripolyphosphate-chitosan microspheres prepared by spray-drying.

    abstract::To prepare the sustained release vitamin C carriers, vitamin C was successfully encapsulated in tripolyphosphate (TPP) cross-linked chitosan (TPP-chitosan) microspheres by the spray-drying method at different manufacturing conditions. Manufacturing parameters (inlet temperature, liquid flow rate, chitosan concentratio...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Desai KG,Park HJ

    更新日期:2006-02-01 00:00:00

  • Impact of the oil droplet size on the oxidative stability of microencapsulated oil.

    abstract::Microencapsulation aims to protect polyunsaturated fatty acids against oxidation by embedding oil droplets in a solid matrix. The effect of the oil droplet size on the oxidation was evaluated under consideration of the non-encapsulated oil and the powder particle size. An O/W emulsion (1.6%(w/w) soy protein; 30.4%(w/w...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Linke A,Hinrichs J,Kohlus R

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  • Effect of encapsulation of mefenamic acid with cationic Eudragit E on its bioavailability and gastric ulcerogenic activity in rabbits.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ramadan EM,el-Helw A,el-Said Y

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  • Preparation and cellular targeting study of VEGF-conjugated PLGA nanoparticles.

    abstract::Vascular endothelial growth factor receptor (VEGFR) is over-expressed on a variety of tumour cells and tumour neovasculature, and so becomes well-documented target for cancer treatment. This study was designed to evaluate the cellular targeting and anti-tumor potency of VEGF-conjugated nanoparticles (VEGF-NPs). The po...

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    pub_type: 杂志文章


    authors: Shi Y,Zhou M,Zhang J,Lu W

    更新日期:2015-01-01 00:00:00

  • Labile conjugation of a hydrophilic drug to PLA oligomers to modify a drug delivery system: cephradin in a PLAGA matrix.

    abstract::The physical entrapment of a hydrophilic drug within degradable microspheres is generally difficult because of poor entrapment yield and/or fast release, depending on the microsphere fabrication method. In order to counter the effects of drug hydrophilicity, it is proposed to covalently attach the drug to lactic acid ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Ustariz-Peyret C,Coudane J,Vert M,Kaltsatos V,Boisramené B

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  • Preparation of polyurea/melamine formaldehyde double-layered self-healing microcapsules and investigation on core fraction.

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    pub_type: 杂志文章


    authors: Ming Y,Hu J,Xing J,Wu M,Qu J

    更新日期:2016-06-01 00:00:00

  • Survivin-miRNA-loaded nanoparticles as auxiliary tools for radiation therapy: preparation, characterisation, drug release, cytotoxicity and therapeutic effect on colorectal cancer cells.

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    pub_type: 杂志文章


    authors: Gaca S,Reichert S,Rödel C,Rödel F,Kreuter J

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  • Studies on the drug release properties of nano-encapsulated indomethacin microparticles.

    abstract::Indomethacin micro-crystals sized approximately 2 microm have been encapsulated with polyelectrolyte multi-layers for the purpose of controlled release. Charged linear poly (dimethyldiallyl ammonium chloride) (PDDA) and poly (styrene sulphonate) (PSS) were alternatively deposited on approximately 2 microm drug micro-c...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Chen Y,Lin X

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  • Microencapsulation of Clostridium acetobutylicum ATCC 824 spores in gellan gum microspheres for the production of biobutanol.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Rathore S,Wan Sia Heng P,Chan LW

    更新日期:2015-01-01 00:00:00

  • Effects of double encapsulation and coating on synthetic seed conversion in M.26 apple rootstock.

    abstract::Encapsulated vitro-derived apical buds of M.26 apple rootstock (Malus pumila Mill) can be employed for the formation of the synthetic seed. Satisfactory levels of conversion (plantlets from synthetic seed) can be achieved if there are adequate (i) rooting induction treatment, (ii) protocol of encapsulation, and (iii) ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Micheli M,Pellegrino S,Piccioni E,Standardi A

    更新日期:2002-05-01 00:00:00

  • Phagocytosis and degradation of human serum albumin microspheres and nanoparticles in human macrophages.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Schäfer V,von Briesen H,Rübsamen-Waigmann H,Steffan AM,Royer C,Kreuter J

    更新日期:1994-05-01 00:00:00

  • Microencapsulation of Lactobacillus rhamnosus GG with flaxseed mucilage using co-extrusion technique.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Lai K,How Y,Pui L

    更新日期:2020-12-28 00:00:00

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Lakkadwala S,Nguyen S,Lawrence J,Nauli SM,Nesamony J

    更新日期:2014-01-01 00:00:00

  • The action of Triton X-100 and sodium dodecyl sulphate on lipid layers. Effect on monolayers and liposomes.

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    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Hernández-Borrell J,Pons M,Juarez JC,Estelrich J

    更新日期:1990-04-01 00:00:00

  • Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation technique. II. Some process parameters influencing the preparation and properties of microspheres.

    abstract::D,L-polylactic acid (PLA) microspheres containing quinidine base and quinidine sulphate were prepared by the solvent evaporation method. The present study was carried out to examine how various process parameters in the aqueous phase influenced the preparation and properties of PLA-microspheres. The amount of drug tha...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Bodmeier R,McGinity JW

    更新日期:1987-10-01 00:00:00

  • Study of azathioprine encapsulation into liposomes.

    abstract::The factors influencing the encapsulation of azathioprine (AZA) into liposomes were investigated to find out the conditions for its optimal entrapment. Similar studies for comparison were also carried out on 6-mercaptopurine (6-MP), of which AZA is a prodrug. AZA and also 6-MP show higher encapsulation efficiencies in...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章


    authors: Gulati M,Grover M,Singh M,Singh S

    更新日期:1998-07-01 00:00:00