Abstract:
:Biodegradable hollow capsules filled with fluorescently labelled bovine serum albumin (BSA) as a model drug were prepared via layer-by-layer (LbL) self-assembly of type-I collagen (COL) and hyaluronic acid (HA) using calcium carbonate micro-particles and co-precipitation method. Capsules loaded with fluorescein isothiocyanate (FITC)-BSA, tetramethylrhodamin isothiocyanate (TRITC)-BSA or Alex-Fluor-488-BSA, respectively, were characterised before and after core removal using Confocal Laser Scanning Microscopy (CLSM), whilst the morphologies of individual hollow capsules were assessed using Atomic Force Microscopy (AFM). The sustained release of the encapsulated FITC-BSA protein was attained using enzymatic degradation of the capsule shells by collagenase. The released profile of the fluorescently-labelled BSA indicated that it could be successfully controlled by modulating the number of layers and/or by collagen crosslinking either before or after the capsule's assembly.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Sousa F,Kreft O,Sukhorukov GB,Möhwald H,Kokol Vdoi
10.3109/02652048.2013.834995subject
Has Abstractpub_date
2014-01-01 00:00:00pages
270-6issue
3eissn
0265-2048issn
1464-5246journal_volume
31pub_type
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