Abstract:
:The release of fluorescein from polyethylcyanoacrylate (PECA) or polyisobutylcyanoacrylate (PICA) nanoparticles was affected by the surfactants used for the preparation. The different surfactants also modified the molecular weight, size and loading of the nanoparticles. However, these factors were not be responsible for the different release. According to the release profiles and the Baker-Lonsdale model, a portion of fluorescein was concentrated near the nanoparticle surface. Thus, a non-homogeneous distribution of the fluorescent probe inside the nanoparticles was hypothesized. This distribution could reflect the fluorescein position inside the micella during the polymerization stage, or could be reached during the washing stage as the consequence of a different effect of the surfactants on the porosity of the nanoparticle structure.
journal_name
J Microencapsuljournal_title
Journal of microencapsulationauthors
Vandelli MA,Fresta M,Puglisi G,Forni Fdoi
10.3109/02652049409034991subject
Has Abstractpub_date
1994-09-01 00:00:00pages
531-8issue
5eissn
0265-2048issn
1464-5246journal_volume
11pub_type
杂志文章abstract::Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2016.1178352
更新日期:2016-06-01 00:00:00
abstract::The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive propertie...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2015.1046516
更新日期:2015-01-01 00:00:00
abstract::Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemic...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109021856
更新日期:1991-01-01 00:00:00
abstract::One of the main challenges in radiation oncology is to overcome the resistance of cancer cells against treatment by molecular targeted approaches. Among the most promising targets is the inhibitor of apoptosis protein survivin, known to be associated with increased tumour aggressiveness and therapy resistance. The obj...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2012.680511
更新日期:2012-01-01 00:00:00
abstract::Microcapsules were prepared through an interfacial cross-linking process using terephthaloylchloride and applied to mixtures of a protein (human serum albumin or gelatin) and a polysaccharide. Their properties were compared with those of microcapsules prepared from the protein alone. Morphological characteristics of m...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049109069560
更新日期:1991-07-01 00:00:00
abstract:PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.651498
更新日期:2012-01-01 00:00:00
abstract::Encapsulation of mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug with cationic acrylic resin, Eudragit E, was carried out using a fluidized-bed granulator (Glatt AG). Three drug:polymer ratios were prepared using 50 ml of 1, 2.5 and 5 per cent w/v aqueous suspension of Eudragit to coat 100 mg powde...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048709021807
更新日期:1987-04-01 00:00:00
abstract::The real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. In the present study, an anti-ulcer drug, ranitidine...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040801973101
更新日期:2008-08-01 00:00:00
abstract::The purpose of this research work was to formulate and systematically evaluate in vitro performance of mucoadhesive microspheres of lacidipine for treatment of pylorospasm. Lacidipine microspheres containing chitosan were prepared by chemical denaturation using glutaraldehyde as a cross-linking agent. The microspheres...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040802376429
更新日期:2009-08-01 00:00:00
abstract::The soft microcapsules containing eucalyptus oil, ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the water-in-oil-in-water type multiple (W/O)/W emulsion. The diameters of the microcapsules and the content and the mi...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2017.1403494
更新日期:2017-12-01 00:00:00
abstract::Monodisperse albumin microspheres were successfully prepared by both chemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersity of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier c...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049809008248
更新日期:1998-09-01 00:00:00
abstract::This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2011.651503
更新日期:2012-01-01 00:00:00
abstract::Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040802127806
更新日期:2009-02-01 00:00:00
abstract::Poly(lactic acid) microcapsules of pilocarpine hydrochloride were prepared and evaluated by measuring a miotic effect in rabbits. The microcapsule suspension showed prolongation of miosis and an improved bioavailability when compared with a standard eye dosage form. ...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048509033840
更新日期:1985-10-01 00:00:00
abstract::The action of two detergents, Triton X-100 and sodium dodecyl sulphate (SDS), on large, unilamellar liposomes was determined as liposome size variation, polydispersity and ability to release a soluble marker from liposomes. Triton X-100 produced stronger effects than SDS. Nevertheless, these differences in behaviour o...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049009021838
更新日期:1990-04-01 00:00:00
abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1863490
更新日期:2020-12-28 00:00:00
abstract::The aim of this work was to investigate the role of HLB of emulsifier as well as volume of the internal aqueous phase (W(1)) and presence of salt in the external aqueous phase (W(2)) on the morphology, size and encapsulation efficiency of poly(D,L-lactide) microspheres containing naltrexone HCl. PLA microparticles con...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040400026392
更新日期:2005-03-01 00:00:00
abstract:AIMS:This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. METHODS:Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and po...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2020.1792566
更新日期:2020-11-01 00:00:00
abstract::Ionotropic gelation was used to entrap sulindac into calcium alginate beads as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Beads were investigated in vitro for a possible sustained drug release and their use in vivo as a gastroprotective system for sulindac. Process parameters such a...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701298153
更新日期:2007-06-01 00:00:00
abstract::Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040210140472
更新日期:2002-09-01 00:00:00
abstract::Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652049409040434
更新日期:1994-01-01 00:00:00
abstract::Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2018.1462416
更新日期:2018-05-01 00:00:00
abstract::Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may no...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040110065413
更新日期:2002-03-01 00:00:00
abstract::A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment f...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040110055225
更新日期:2002-11-01 00:00:00
abstract::Using liposomes radiolabelled by the 99mTechnetium-stannous chloride technique we have investigated the effect of surface charge on the stability of the isotope in vitro and in vivo. Dialysis of 99mTc-labelled positive, negative and neutral liposomes, which had been incubated in either saline or normal rat serum showe...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048909019907
更新日期:1989-01-01 00:00:00
abstract::Capsules have been prepared based on a polyanion blend of sodium alginate and sodium cellulose sulphate, gelled in the presence of calcium chloride and sodium chloride. In a second step a membrane was formed via the addition of polymethylene-co-guanidine (PMCG), an oligocation. A mechanistic study examined the influen...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040601058418
更新日期:2007-02-01 00:00:00
abstract::Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a sa...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040701657820
更新日期:2007-12-01 00:00:00
abstract::Polyurethane modified with polylactic acid microcapsules were fabricated for controlled release of chlorpyrifos (one of the high usage solid phosphorous insecticides) via interfacial polymerisation with diphenylmethane diisocyanate, polyether triol, 1,4-butanediol and polylactic acid as modifier. The structure, morpho...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652048.2019.1599075
更新日期:2019-01-01 00:00:00
abstract::The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was sl...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.1080/02652040410001729241
更新日期:2004-06-01 00:00:00
abstract::The purpose of the present study was to provide further insights on the applicability of microencapsulation using emulsification method, to immobilise Clostridium acetobutylicum ATCC 824 spores, for biobutanol production. The encapsulated spores were revived using heat shock treatment and the fermentation efficiency o...
journal_title:Journal of microencapsulation
pub_type: 杂志文章
doi:10.3109/02652048.2015.1017617
更新日期:2015-01-01 00:00:00