An interpretative analysis of the effect of the surfactants used for the preparation of polyalkylcyanoacrylate nanoparticles on the release process.

Abstract:

:The release of fluorescein from polyethylcyanoacrylate (PECA) or polyisobutylcyanoacrylate (PICA) nanoparticles was affected by the surfactants used for the preparation. The different surfactants also modified the molecular weight, size and loading of the nanoparticles. However, these factors were not be responsible for the different release. According to the release profiles and the Baker-Lonsdale model, a portion of fluorescein was concentrated near the nanoparticle surface. Thus, a non-homogeneous distribution of the fluorescent probe inside the nanoparticles was hypothesized. This distribution could reflect the fluorescein position inside the micella during the polymerization stage, or could be reached during the washing stage as the consequence of a different effect of the surfactants on the porosity of the nanoparticle structure.

journal_name

J Microencapsul

authors

Vandelli MA,Fresta M,Puglisi G,Forni F

doi

10.3109/02652049409034991

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

531-8

issue

5

eissn

0265-2048

issn

1464-5246

journal_volume

11

pub_type

杂志文章
  • Preparation of polyurea/melamine formaldehyde double-layered self-healing microcapsules and investigation on core fraction.

    abstract::Moisture curing type self-healing microcapsules become more attractive, while instability of active core material crippled the efficiency of self-healing behaviour. Polyurea (PU)/melamine formaldehyde (MF) double-layered self-healing microcapsules containing isophorone diisocyanate (IPDI) core with high and stable cor...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2016.1178352

    authors: Ming Y,Hu J,Xing J,Wu M,Qu J

    更新日期:2016-06-01 00:00:00

  • Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system.

    abstract::The purpose of this study was to design and characterise an oral mucoadhesive micellar drug carrier. In this regard, a mucoadhesive hydrophobic cationic aminocellulose was easily synthesised under mild homogeneous conditions with high yield. The cellulose derivative resulted in strongly improved mucoadhesive propertie...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2015.1046516

    authors: Songsurang K,Siraleartmukul K,Muangsin N

    更新日期:2015-01-01 00:00:00

  • Drug targeting using non-magnetic and magnetic albumin-globulin mix microspheres of mefenamic acid.

    abstract::Optimum conditions for the preparation of non-magnetic and magnetic microspheres of albumin-globulin mix (alglomix) containing mefenamic acid have been standardized. The effect of various parameters has been investigated with regard to the appearance, yield, drug content and encapsulation efficiency. The physicochemic...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049109021856

    authors: Lalla JK,Ahuja PL

    更新日期:1991-01-01 00:00:00

  • Survivin-miRNA-loaded nanoparticles as auxiliary tools for radiation therapy: preparation, characterisation, drug release, cytotoxicity and therapeutic effect on colorectal cancer cells.

    abstract::One of the main challenges in radiation oncology is to overcome the resistance of cancer cells against treatment by molecular targeted approaches. Among the most promising targets is the inhibitor of apoptosis protein survivin, known to be associated with increased tumour aggressiveness and therapy resistance. The obj...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2012.680511

    authors: Gaca S,Reichert S,Rödel C,Rödel F,Kreuter J

    更新日期:2012-01-01 00:00:00

  • Mixed-wall microcapsules made of cross-linked proteins and polysaccharides: preparation and properties.

    abstract::Microcapsules were prepared through an interfacial cross-linking process using terephthaloylchloride and applied to mixtures of a protein (human serum albumin or gelatin) and a polysaccharide. Their properties were compared with those of microcapsules prepared from the protein alone. Morphological characteristics of m...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049109069560

    authors: Levy MC,Andry MC

    更新日期:1991-07-01 00:00:00

  • Ciprofloxacin hydrochloride-loaded glyceryl monostearate nanoparticle: factorial design of Lutrol F68 and Phospholipon 90G.

    abstract:PURPOSE:This investigation was undertaken to develop glyceryl monostearate (Geleol)-based solid lipid nanoparticles (SLNs) of a hydrophilic drug ciprofloxacin HCl. METHODS:Hansen's solubility parameter study was carried out in screening of a suitable carrier and solvent system. Subsequently, SLNs were prepared by solv...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2011.651498

    authors: Shah M,Agrawal Y

    更新日期:2012-01-01 00:00:00

  • Effect of encapsulation of mefenamic acid with cationic Eudragit E on its bioavailability and gastric ulcerogenic activity in rabbits.

    abstract::Encapsulation of mefenamic acid (MFA), a potent non-steroidal anti-inflammatory drug with cationic acrylic resin, Eudragit E, was carried out using a fluidized-bed granulator (Glatt AG). Three drug:polymer ratios were prepared using 50 ml of 1, 2.5 and 5 per cent w/v aqueous suspension of Eudragit to coat 100 mg powde...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048709021807

    authors: Ramadan EM,el-Helw A,el-Said Y

    更新日期:1987-04-01 00:00:00

  • In vitro and in vivo evaluation of ranitidine hydrochloride ethyl cellulose floating microparticles.

    abstract::The real issue in the development of oral controlled release dosage forms is not just to prolong the delivery of drugs but also to prolong the presence of dosage forms in the stomach in order to improve the bioavailability of drugs with a 'narrow absorption window'. In the present study, an anti-ulcer drug, ranitidine...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040801973101

    authors: Mastiholimath VS,Dandagi PM,Gadad AP,Mathews R,Kulkarni AR

    更新日期:2008-08-01 00:00:00

  • Lacidipine encapsulated gastroretentive microspheres prepared by chemical denaturation for pylorospasm.

    abstract::The purpose of this research work was to formulate and systematically evaluate in vitro performance of mucoadhesive microspheres of lacidipine for treatment of pylorospasm. Lacidipine microspheres containing chitosan were prepared by chemical denaturation using glutaraldehyde as a cross-linking agent. The microspheres...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040802376429

    authors: Sultana S,Bhavna,Iqbal Z,Panda BP,Talegaonkar S,Bhatnagar A,Ahmad FJ

    更新日期:2009-08-01 00:00:00

  • Preparation of soft microcapsules containing multiple core materials with interfacial dehydration reaction using the (W/O)/W emulsion.

    abstract::The soft microcapsules containing eucalyptus oil, ubiquinone and the fine water droplets could be prepared with interfacial dehydration reaction between hydroxy methyl cellulose and tannic acid using the water-in-oil-in-water type multiple (W/O)/W emulsion. The diameters of the microcapsules and the content and the mi...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2017.1403494

    authors: Taguchi Y,Suzuki T,Saito N,Yokoyama H,Tanaka M

    更新日期:2017-12-01 00:00:00

  • Effects of preparation conditions on the monodispersity of albumin microspheres.

    abstract::Monodisperse albumin microspheres were successfully prepared by both chemical or thermal hardening methods via membrane emulsification using microporous glass membranes with uniform pore sizes. The monodispersity of the microspheres was found to depend strongly on parameters such as albumin concentration, emulsifier c...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049809008248

    authors: el-Mahdy M,Ibrahim ES,Safwat S,el-Sayed A,Ohshima H,Makino K,Muramatsu N,Kondo T

    更新日期:1998-09-01 00:00:00

  • Spray-dried microparticles: a potential vehicle for oral delivery of vaccines.

    abstract::This study aims to formulate a microparticle-based system that protects the protein from the harsh gastric conditions and also provides appropriate uptake via M cells for desired immune response upon oral administration. The formulation was derived using a valid statistical model, analysed by JMP® (SAS). The average s...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2011.651503

    authors: Chablani L,Tawde SA,D'Souza MJ

    更新日期:2012-01-01 00:00:00

  • Microencapsulated electric ink using gelatin/gum arabic.

    abstract::Gelatin/gum arabic (GA) microcapsules were prepared by a convenient one step complex coacervation, in which TiO2 nanoparticles modified by stearic acid (SA) and homodispersed in tetrachloroethylene (TCE) were encapsulated. The modified TiO2 was characterized by Fourier transform infrared spectroscopy (FT-IR), dynamic ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040802127806

    authors: Wang DW,Zhao XP

    更新日期:2009-02-01 00:00:00

  • The in vivo evaluation of poly(lactic acid) microcapsules of pilocarpine hydrochloride.

    abstract::Poly(lactic acid) microcapsules of pilocarpine hydrochloride were prepared and evaluated by measuring a miotic effect in rabbits. The microcapsule suspension showed prolongation of miosis and an improved bioavailability when compared with a standard eye dosage form. ...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048509033840

    authors: Vidmar V,Pepeljnjak S,Jalsenjak I

    更新日期:1985-10-01 00:00:00

  • The action of Triton X-100 and sodium dodecyl sulphate on lipid layers. Effect on monolayers and liposomes.

    abstract::The action of two detergents, Triton X-100 and sodium dodecyl sulphate (SDS), on large, unilamellar liposomes was determined as liposome size variation, polydispersity and ability to release a soluble marker from liposomes. Triton X-100 produced stronger effects than SDS. Nevertheless, these differences in behaviour o...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049009021838

    authors: Hernández-Borrell J,Pons M,Juarez JC,Estelrich J

    更新日期:1990-04-01 00:00:00

  • Microencapsulation of Lactobacillus rhamnosus GG with flaxseed mucilage using co-extrusion technique.

    abstract:AIM:This study aimed to evaluate the protective effect of flaxseed mucilage on the co-extrusion microencapsulation of Lactobacillus rhamnosus GG. METHODS:Core flow rate, chitosan coating, and flaxseed mucilage concentration were optimised for the microencapsulation of L. rhamnosus. The microbeads were characterised an...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2020.1863490

    authors: Lai K,How Y,Pui L

    更新日期:2020-12-28 00:00:00

  • Effect of surfactant HLB and different formulation variables on the properties of poly-D,L-lactide microspheres of naltrexone prepared by double emulsion technique.

    abstract::The aim of this work was to investigate the role of HLB of emulsifier as well as volume of the internal aqueous phase (W(1)) and presence of salt in the external aqueous phase (W(2)) on the morphology, size and encapsulation efficiency of poly(D,L-lactide) microspheres containing naltrexone HCl. PLA microparticles con...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040400026392

    authors: Dinarvand R,Moghadam SH,Sheikhi A,Atyabi F

    更新日期:2005-03-01 00:00:00

  • Exploiting ionisable nature of PEtOx-co-PEI to prepare pH sensitive, doxorubicin-loaded micelles.

    abstract:AIMS:This study was conducted to evaluate block copolymers containing two different poly(ethyleneimine) (PEI) amounts, as new pH-sensitive micellar delivery systems for doxorubicin. METHODS:Micelles were prepared with block copolymers consisting of poly(2-ethyl-2-oxazoline)-co-poly(ethyleneimine) (PEtOx-co-PEI) and po...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2020.1792566

    authors: Ozturk N,Kara A,Gulyuz S,Ozkose UU,Tasdelen MA,Bozkir A,Yilmaz O,Vural I

    更新日期:2020-11-01 00:00:00

  • Sulindac loaded alginate beads for a mucoprotective and controlled drug release.

    abstract::Ionotropic gelation was used to entrap sulindac into calcium alginate beads as a potential drug carrier for the oral delivery of this anti-inflammatory drug. Beads were investigated in vitro for a possible sustained drug release and their use in vivo as a gastroprotective system for sulindac. Process parameters such a...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040701298153

    authors: Yegin BA,Moulari B,Durlu-Kandilci NT,Korkusuz P,Pellequer Y,Lamprecht A

    更新日期:2007-06-01 00:00:00

  • Microencapsulation of fragrant oil via in situ polymerization: effects of pH and melamine-formaldehyde molar ratio.

    abstract::Microcapsules containing fragrant oil (Foral oil) were synthesized via the in situ polymerization method using melamine-formaldehyde (M-F) as a wall material. The encapsulation efficiency and other physical properties were analysed with varying formaldehyde/melamine (F/M) mole ratio and pH of emulsion medium. The pH o...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040210140472

    authors: Lee HY,Lee SJ,Cheong IW,Kim JH

    更新日期:2002-09-01 00:00:00

  • Preparation and study of release kinetics of rosin pentaerythritol ester microcapsules.

    abstract::Rosin was esterified with pentaerythritol and intermediate reaction products with different acid values were isolated. Microcapsules containing sulphadiazine were prepared by a solvent evaporation technique using these esters as wall materials. The microcapsules were evaluated for their size, drug content, and release...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652049409040434

    authors: Sheorey DS,Dorle AK

    更新日期:1994-01-01 00:00:00

  • Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers.

    abstract::Freeze-drying is an effective way to improve long-term physical stability of nanosuspension in drug delivery applications. Nanosuspension also known as suspension of nanoparticles. In this study, the effect of freeze-drying with different cryoprotectants on the physicochemical characteristics of resveratrol (RSV) nano...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2018.1462416

    authors: Wang L,Ma Y,Gu Y,Liu Y,Zhao J,Yan B,Wang Y

    更新日期:2018-05-01 00:00:00

  • In vitro antibiotic release from poly(3-hydroxybutyrate-co-3-hydroxyvalerate) rods.

    abstract::Provision and maintenance of adequate concentrations of antibiotics at infection sites is very important in treating highly resistant infections. For diseases like implant related osteomyelitis (IRO) it is best to provide this locally via implanted drug formulations, as systemic administration of the antibiotic may no...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040110065413

    authors: Gurselt I,Yagmurlu F,Korkusuz F,Hasirci V

    更新日期:2002-03-01 00:00:00

  • The synthesis of semipermeable membrane microcapsules using in situ cyanoacrylate ester polymerization.

    abstract::A new material for the microencapsulation of biological systems was discovered and characterized with regards to the effects of reaction conditions on product yield. By using poly(cyanoacrylate ester), membrane microcapsules were produced with sufficient strength and porosity to be effective in a process environment f...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040110055225

    authors: Holl RJ,Chambers RP

    更新日期:2002-11-01 00:00:00

  • Effect of liposome surface charge on the stability of technetium (99mTc) radiolabelled liposomes.

    abstract::Using liposomes radiolabelled by the 99mTechnetium-stannous chloride technique we have investigated the effect of surface charge on the stability of the isotope in vitro and in vivo. Dialysis of 99mTc-labelled positive, negative and neutral liposomes, which had been incubated in either saline or normal rat serum showe...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048909019907

    authors: Love WG,Amos N,Williams BD,Kellaway IW

    更新日期:1989-01-01 00:00:00

  • Polymethylene-co-guanidine based capsules: a mechanistic study of the formation using alginate and cellulose sulphate.

    abstract::Capsules have been prepared based on a polyanion blend of sodium alginate and sodium cellulose sulphate, gelled in the presence of calcium chloride and sodium chloride. In a second step a membrane was formed via the addition of polymethylene-co-guanidine (PMCG), an oligocation. A mechanistic study examined the influen...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040601058418

    authors: Renken A,Hunkeler D

    更新日期:2007-02-01 00:00:00

  • pH-dependent release property of alginate beads containing calcium carbonate particles.

    abstract::Alginate bead containing calcium carbonate particle were prepared by dropping the suspension of alginate/calcium carbonate (4/1, w/w) into aqueous solution of CaCl(2) (0.1 M). The pH-dependent release property of the bead was observed for 12 h using blue dextran as a model drug. The release increased up to 4 h in a sa...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040701657820

    authors: Han MR,Kwon MC,Lee HY,Kim JC,Kim JD,Yoo SK,Sin IS,Kim SM

    更新日期:2007-12-01 00:00:00

  • Preparation and characterisation of polylactic acid modified polyurethane microcapsules for controlled-release of chlorpyrifos.

    abstract::Polyurethane modified with polylactic acid microcapsules were fabricated for controlled release of chlorpyrifos (one of the high usage solid phosphorous insecticides) via interfacial polymerisation with diphenylmethane diisocyanate, polyether triol, 1,4-butanediol and polylactic acid as modifier. The structure, morpho...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652048.2019.1599075

    authors: Zheng T,Chen K,Chen W,Wu B,Sheng Y,Xiao Y

    更新日期:2019-01-01 00:00:00

  • Nifedipine encapsulated core-shell type nanoparticles based on poly(gamma-benzyl L-glutamate)/poly(ethylene glycol) diblock copolymers.

    abstract::The diblock copolymers based on PBLG and PEO (GE) were synthesized and characterized. Nanoparticles showed spherical shape from the observations of TEM and approved core-shell structure. Drug contents were increased with use of higher initial drug concentration and higher Mw of GE. Nifedipine (NFD) release rate was sl...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.1080/02652040410001729241

    authors: Jeong YI,Sun HS,Shim YH,Kim C,Park SH,Choi KC,Cho CS

    更新日期:2004-06-01 00:00:00

  • Microencapsulation of Clostridium acetobutylicum ATCC 824 spores in gellan gum microspheres for the production of biobutanol.

    abstract::The purpose of the present study was to provide further insights on the applicability of microencapsulation using emulsification method, to immobilise Clostridium acetobutylicum ATCC 824 spores, for biobutanol production. The encapsulated spores were revived using heat shock treatment and the fermentation efficiency o...

    journal_title:Journal of microencapsulation

    pub_type: 杂志文章

    doi:10.3109/02652048.2015.1017617

    authors: Rathore S,Wan Sia Heng P,Chan LW

    更新日期:2015-01-01 00:00:00