Abstract:
:DNA damage signaling and checkpoint control pathways are among the most commonly mutated networks in human tumors. Emerging data suggest that synthetic lethal interactions between mutated oncogenes or tumor suppressor genes with molecules involved in the DNA damage response and DNA repair pathways can be therapeutically exploited to preferentially kill cancer cells. In this review, we discuss the concept of synthetic lethality with a focus on p53, a commonly lost tumor suppressor gene, in the context of DNA damage signaling. We describe several recent examples in which this concept was successfully applied to target tumor cells in culture or in mouse models, as well as in human cancer patients.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Morandell S,Yaffe MBdoi
10.1016/B978-0-12-387665-2.00011-0subject
Has Abstractpub_date
2012-01-01 00:00:00pages
289-314eissn
1877-1173issn
1878-0814pii
B978-0-12-387665-2.00011-0journal_volume
110pub_type
杂志文章,评审abstract::Both genetic and environmental factors play roles in the development of refractive errors. Identification of genes involved in refractive errors may help in elucidating the underlying molecular mechanism related to both genetic defects and environmental pressure. Recent development of techniques for genome wide analys...
journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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更新日期:2010-01-01 00:00:00
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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更新日期:2013-01-01 00:00:00
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
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journal_title:Progress in molecular biology and translational science
pub_type: 杂志文章,评审
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journal_title:Progress in molecular biology and translational science
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更新日期:2011-01-01 00:00:00