Contribution of mechanosensitive ion channels to somatosensation.

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:Reported exposure to traumatic event is relatively common within the general population (40-90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD). Indeed, the lifetime prevalence of PTSD is estimated to range between 7% and 12%. The factors influencing risk or resilience to PTSD af...

journal_title：Progress in molecular biology and translational science

authors： Rampp C,Binder EB,Provençal N

更新日期：2014-01-01 00:00:00

abstract：:Here we describe the principles of protein surgery and its application to the molecular design for regulating the protein conformation. We initially describe the Poincare duality that defines the basis of complementarity in the time-dependent geometrical space. Next we introduce the theory of protein surgery consistin...

journal_title：Progress in molecular biology and translational science

authors： Kuwata K

更新日期：2020-01-01 00:00:00

abstract：:Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators ...

journal_title：Progress in molecular biology and translational science

authors： Chen J,Khalil RA

更新日期：2017-01-01 00:00:00

abstract：:Ribosomal protein S6 kinase (S6K) has been implicated in the phosphorylation of multiple substrates and is subject to activation by a wide variety of signals that converge at mammalian target of rapamycin (mTOR). In the course of the search for its physiological role, it was proposed that S6K activation and ribosomal ...

journal_title：Progress in molecular biology and translational science

authors： Meyuhas O,Dreazen A

更新日期：2009-01-01 00:00:00

abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...

journal_title：Progress in molecular biology and translational science

authors： Thorburn A

更新日期：2020-01-01 00:00:00

abstract：:Midbrain dopamine neurons are pacemakers in vitro, but in vivo they fire less regularly and occasionally in bursts that can lead to a temporary cessation in firing produced by depolarization block. The therapeutic efficacy of antipsychotic drugs used to treat the positive symptoms of schizophrenia has been attributed ...

journal_title：Progress in molecular biology and translational science

authors： Yu N,Tucker KR,Levitan ES,Shepard PD,Canavier CC

更新日期：2014-01-01 00:00:00

abstract：:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental ri...

journal_title：Progress in molecular biology and translational science

authors： Pietropaolo S,Bellocchio L,Bouzón-Arnáiz I,Yee BK

更新日期：2020-01-01 00:00:00

abstract：:Transmissible spongiform encephalopathies or prion diseases describe a number of different human disorders that differ in their clinical phenotypes, which are nonetheless united by their transmissible nature and common pathology. Clinical variation in the absence of a conventional infectious agent is believed to be en...

journal_title：Progress in molecular biology and translational science

authors： Ellett LJ,Revill ZT,Koo YQ,Lawson VA

更新日期：2020-01-01 00:00:00

abstract：:Heterotrimeric G proteins convey receptor signals to intracellular effectors. Superimposed over the basic GPCR-G protein-effector scheme are three types of auxiliary proteins that also modulate Gα. Regulator of G protein signaling proteins and G protein signaling modifier proteins respectively promote GTPase activity ...

journal_title：Progress in molecular biology and translational science

authors： Zhao P,Cladman W,Van Tol HH,Chidiac P

更新日期：2013-01-01 00:00:00

abstract：:Viruses have evolved to exploit the vast complexity of cellular processes for their success within the host cell. The entry mechanisms of enveloped viruses (viruses with a surrounding outer lipid bilayer membrane) are usually classified as being either endocytotic or fusogenic. Different mechanisms have been proposed ...

journal_title：Progress in molecular biology and translational science

authors： Vancini R,Hernandez R,Brown D

更新日期：2015-01-01 00:00:00

abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...

journal_title：Progress in molecular biology and translational science

authors： He Y,Zhang L,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Among the most sensitive, specific and practical of methods for detecting prions are the real-time quaking-induced conversion (RT-QuIC) assays. These assays exploit the fundamental self-propagating activity of prions to amplify the presence of prion seeds by as much as a trillion-fold. The reactions can detect most of...

journal_title：Progress in molecular biology and translational science

authors： Caughey B,Orru CD,Groveman BR,Hughson AG,Manca M,Raymond LD,Raymond GJ,Race B,Saijo E,Kraus A

更新日期：2017-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...

journal_title：Progress in molecular biology and translational science

authors： Bohinc BN,Gesty-Palmer D

更新日期：2013-01-01 00:00:00

abstract：:The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to re...

journal_title：Progress in molecular biology and translational science

authors： Salomon C,Rice GE

更新日期：2017-01-01 00:00:00

abstract：:In this chapter, we describe how to create mathematical models of synaptic transmission and integration. We start with a brief synopsis of the experimental evidence underlying our current understanding of synaptic transmission. We then describe synaptic transmission at a particular glutamatergic synapse in the mammali...

journal_title：Progress in molecular biology and translational science

authors： Rothman JS,Silver RA

更新日期：2014-01-01 00:00:00

abstract：:The control of immune responses against self and nonharmful environmental antigens is of critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players of such immune regulation and their deficiency and dysfunction are associated with various immune disorders, such as autoimmunity and all...

journal_title：Progress in molecular biology and translational science

authors： Kitagawa Y,Wing JB,Sakaguchi S

更新日期：2015-01-01 00:00:00

abstract：:A metaplastic change where normal squamous mucosa of the esophagus is replaced by columnar mucosa is considered an adaptive process to withstand the chronic gastroesophageal reflux injury. However, this phenotypic switch in the esophageal mucosa is associated with an increased propensity to undergo neoplastic transfor...

journal_title：Progress in molecular biology and translational science

authors： Singh A,Demars C,Buttar NS

更新日期：2010-01-01 00:00:00

abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...

journal_title：Progress in molecular biology and translational science

authors： Baines AT,Martin PM,Rorie CJ

更新日期：2016-01-01 00:00:00

abstract：:Mitochondria are well-known cellular organelles that play a vital role in cellular bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism, and other metabolic activities. Given the extensive role of mitochondria in cell function, mitochondrial dysfunction plays a part in many diseases, ...

journal_title：Progress in molecular biology and translational science

authors： Akhter F,Chen D,Yan SF,Yan SS

更新日期：2017-01-01 00:00:00

abstract：:Transition metals such as manganese are essential nutrients for both pathogen and host. Vertebrates exploit this necessity to combat invading microbes by restricting access to these critical nutrients, a defense known as nutritional immunity. During infection, the host uses several mechanisms to impose manganese limit...

journal_title：Progress in molecular biology and translational science

authors： Kelliher JL,Kehl-Fie TE

更新日期：2016-01-01 00:00:00

abstract：:Mutations in SNCA, PINK1, parkin, and DJ-1 are associated with autosomal-dominant or autosomal-recessive forms of Parkinson's disease (PD), the second most common neurodegenerative disorder. Studies on the structural and functional properties of the corresponding gene products have provided significant insights into t...

journal_title：Progress in molecular biology and translational science

authors： Rochet JC,Hay BA,Guo M

更新日期：2012-01-01 00:00:00

abstract：:The etiology of obesity is multifactorial, involving complex interactions among the genetic makeup, neuroendocrine status, fetal programming, and different unhealthy environmental factors, such as sedentarism or inadequate dietary habits. Among the different mechanisms causing obesity, epigenetics, defined as the stud...

journal_title：Progress in molecular biology and translational science

authors： Campión J,Milagro F,Martínez JA

更新日期：2010-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes mellitus and is also associated with several other diseases, such as obesity, hypertension, and cardiovascular diseases. Type 2 diabetes and obesity have become epidemic worldwide in the past few decades, and epidemiological and metabolic eviden...

journal_title：Progress in molecular biology and translational science

authors： Rachek LI

更新日期：2014-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families ex...

journal_title：Progress in molecular biology and translational science

authors： Roberts AP,Lewis AP,Jopling CL

更新日期：2011-01-01 00:00:00

abstract：:Ndsts (N-deacetylase/N-sulfotransferases) are enzymes responsible for N-sulfation during heparan sulfate (HS) and heparin biosynthesis. In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented. Effects of Ndst1 deficiency on embryonic dev...

journal_title：Progress in molecular biology and translational science

authors： Ringvall M,Kjellén L

更新日期：2010-01-01 00:00:00

abstract：:Genomic imprinting is the phenomenon where the expression of a locus differs between the maternally and paternally inherited alleles. Typically, this manifests as transcriptional silencing of one of the alleles, although many genes are imprinted in a tissue- or isoform-specific manner. Diseases associated with imprint...

journal_title：Progress in molecular biology and translational science

authors： Wilkins JF,Úbeda F

更新日期：2011-01-01 00:00:00

abstract：:Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration. The bis-retino...

journal_title：Progress in molecular biology and translational science

authors： Crouch RK,Koutalos Y,Kono M,Schey K,Ablonczy Z

更新日期：2015-01-01 00:00:00

abstract：:Single-molecule approaches permit an unrivalled view of how complex systems operate and have recently been used to understand DNA-protein interactions. These tools have enabled advances in a particularly challenging problem, the search for damaged sites on DNA. DNA repair proteins are present at the level of just a fe...

journal_title：Progress in molecular biology and translational science

authors： Kad NM,Van Houten B

更新日期：2012-01-01 00:00:00

abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...

journal_title：Progress in molecular biology and translational science

authors： Avni A,Swasthi HM,Majumdar A,Mukhopadhyay S

更新日期：2019-01-01 00:00:00