Data-driven modeling of synaptic transmission and integration.

abstract：:Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators ...

journal_title：Progress in molecular biology and translational science

authors： Chen J,Khalil RA

更新日期：2017-01-01 00:00:00

abstract：:Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the ...

journal_title：Progress in molecular biology and translational science

authors： Zhang YP,Zhang YY,Duan DD

更新日期：2016-01-01 00:00:00

abstract：:The production of transgenic mice expressing different forms of the prion protein (PrP) or devoid of PrP has enabled researchers to study the role of PrP in the infectious process of a prion disease and its normal function in the healthy individual. A wide range of transgenic models have been produced ranging from PrP...

journal_title：Progress in molecular biology and translational science

authors： Diack AB,Alibhai JD,Manson JC

更新日期：2017-01-01 00:00:00

abstract：:The hair follicle has been known, since 1990, to contain stem cells located in the bulge area. In 2003, we reported a new type of stem cell in the hair follicle that expresses the brain stem-cell marker nestin. We have termed these cells as hair-follicle-associated pluripotent (HAP) stem cells. HAP stem cells can diff...

journal_title：Progress in molecular biology and translational science

authors： Hoffman RM,Amoh Y

更新日期：2018-01-01 00:00:00

abstract：:In 1982, the Cech group discovered that an intron structure in an rRNA precursor of Tetrahymena thermophila is sufficient to complete splicing without assistance from proteins. This was the first moment that scientists recognized RNAs can have catalytic activities derived from their own unique three-dimensional struct...

journal_title：Progress in molecular biology and translational science

authors： Lee CH,Han SR,Lee SW

更新日期：2018-01-01 00:00:00

abstract：:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular m...

journal_title：Progress in molecular biology and translational science

authors： Ovcinnikovs V,Walker LS

更新日期：2015-01-01 00:00:00

abstract：:Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic pat...

journal_title：Progress in molecular biology and translational science

authors： Wang X,Zhang R,Zhang L,Tian Z

更新日期：2019-01-01 00:00:00

abstract：:The pituitary gonadotrope is central to reproductive function. Gonadotropes develop in a systematic process dependent on signaling factors secreted from surrounding tissues and those produced within the pituitary gland itself. These signaling pathways are important for stimulating specific transcription factors that u...

journal_title：Progress in molecular biology and translational science

authors： Stallings CE,Kapali J,Ellsworth BS

更新日期：2016-01-01 00:00:00

abstract：:Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current ...

journal_title：Progress in molecular biology and translational science

authors： Lardenoije R,Pishva E,Lunnon K,van den Hove DL

更新日期：2018-01-01 00:00:00

abstract：:Over the last two centuries, the discovery and understanding of the principle of fluorescence have provided new means of characterizing physical/biological/chemical processes in a noninvasive manner. Fluorescence spectroscopy has become one of the most powerful and widely applied methods in the life sciences, from fun...

journal_title：Progress in molecular biology and translational science

authors： Deshayes S,Divita G

更新日期：2013-01-01 00:00:00

abstract：:Cadherin-based cell-cell adhesions are dynamic structures that mediate tissue organization and morphogenesis. They link cells together, mediate cell-cell recognition, and influence cell shape, motility, proliferation, and differentiation. At the cellular level, operation of classical cadherin adhesion systems is coord...

journal_title：Progress in molecular biology and translational science

authors： Ratheesh A,Priya R,Yap AS

更新日期：2013-01-01 00:00:00

abstract：:The failure of neuropathic pain to abate even years after trauma suggests that adverse changes to synaptic function must exist in a chronic pathological state in nociceptive pathways. The chronicity of neuropathic pain therefore underscores the importance of understanding the contribution of dendritic spines--micron-s...

journal_title：Progress in molecular biology and translational science

authors： Tan AM

更新日期：2015-01-01 00:00:00

abstract：:Workers experience large interindividual variability in exposure and biological response following exposure to chemicals. Quantitative methods to investigate occupational exposures and their relationship with biomarker levels, toxicokinetics of chemicals, and gene-environment interactions in disease development can be...

journal_title：Progress in molecular biology and translational science

authors： Flack S,Nylander-French LA

更新日期：2012-01-01 00:00:00

abstract：:Bombesin (Bn) is a 14-amino acid peptide isolated from the skin of the frog Bombina bombina. The mammalian homologs of this peptide include three forms of gastrin-releasing peptide (GRP): GRP-10, GRP-27, and GRP-29, and a 10-amino acid peptide referred to as neuromedin-B (NMB). These peptides evoke a number of respons...

journal_title：Progress in molecular biology and translational science

authors： Sayegh AI

更新日期：2013-01-01 00:00:00

abstract：:Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and ch...

journal_title：Progress in molecular biology and translational science

authors： Betthauser TJ

更新日期：2019-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes mellitus and is also associated with several other diseases, such as obesity, hypertension, and cardiovascular diseases. Type 2 diabetes and obesity have become epidemic worldwide in the past few decades, and epidemiological and metabolic eviden...

journal_title：Progress in molecular biology and translational science

authors： Rachek LI

更新日期：2014-01-01 00:00:00

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:The increased prevalence of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, and fatty liver disease has provided increasingly negative connotations toward lipids. However, it is important to remember that lipids are essential components supporting life. Lipids are a class of molecules defined by their inhe...

journal_title：Progress in molecular biology and translational science

authors： Noland RC

更新日期：2015-01-01 00:00:00

abstract：:Cannabis has been cultivated and used by humans for thousands of years. Research for decades was focused on understanding the mechanisms of an illegal/addictive drug. This led to the discovery of the vast endocannabinoid system. Research has now shifted to understanding fundamental biological questions related to one ...

journal_title：Progress in molecular biology and translational science

authors： Ronan PJ,Wongngamnit N,Beresford TP

更新日期：2016-01-01 00:00:00

abstract：:Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elem...

journal_title：Progress in molecular biology and translational science

authors： Gurevich VV,Gurevich EV

更新日期：2013-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is a glycoprotein and belongs to the gene family of serum albumins. The serum AFP levels were found to be elevated in the sera of liver cancer patients in 1964 and were subsequently developed and used as a liver cancer biomarker. However, elevated serum AFP levels have been observed in patients...

journal_title：Progress in molecular biology and translational science

authors： He Y,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：:Ribosomal protein S6 kinase (S6K) has been implicated in the phosphorylation of multiple substrates and is subject to activation by a wide variety of signals that converge at mammalian target of rapamycin (mTOR). In the course of the search for its physiological role, it was proposed that S6K activation and ribosomal ...

journal_title：Progress in molecular biology and translational science

authors： Meyuhas O,Dreazen A

更新日期：2009-01-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutic...

journal_title：Progress in molecular biology and translational science

authors： Corbo CP,Alonso Adel C

更新日期：2011-01-01 00:00:00

abstract：:The muscular dystrophies (MDs) represent a diverse collection of inherited human disorders, which affect to varying degrees skeletal, cardiac, and sometimes smooth muscle (Emery, 2002). To date, more than 50 different genes have been implicated as causing one or more types of MD (Bansal et al., 2003). In many cases, i...

journal_title：Progress in molecular biology and translational science

authors： Ng R,Banks GB,Hall JK,Muir LA,Ramos JN,Wicki J,Odom GL,Konieczny P,Seto J,Chamberlain JR,Chamberlain JS

更新日期：2012-01-01 00:00:00

abstract：:Over the past two decades, new technologies enabling targeted modification of plant genomes have been developed. Among these are zinc-finger nucleases (ZFNs) which are composed of engineered zinc-finger DNA-binding domains fused with a nuclease, generally the FokI nuclease. The zinc-finger domains are composed of a se...

journal_title：Progress in molecular biology and translational science

authors： Davies JP,Kumar S,Sastry-Dent L

更新日期：2017-01-01 00:00:00

abstract：:Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life events, such as childhood maltreatment, has been linked to...

journal_title：Progress in molecular biology and translational science

authors： Dick A,Provencal N

更新日期：2018-01-01 00:00:00

abstract：:The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attempt to understand hammerhead ribozyme catalysis in terms of structure....

journal_title：Progress in molecular biology and translational science

authors： Scott WG,Horan LH,Martick M

更新日期：2013-01-01 00:00:00

abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...

journal_title：Progress in molecular biology and translational science

authors： Baines AT,Martin PM,Rorie CJ

更新日期：2016-01-01 00:00:00

abstract：:The Wnt family of secreted glycoproteins participates in a wide array of biological processes, including cellular differentiation, proliferation, survival, apoptosis, adhesion, angiogenesis, hypertrophy, and aging. The canonical Wnt signaling primarily utilizes β-catenin-mediated activation of transcription, while the...

journal_title：Progress in molecular biology and translational science

authors： Flaherty MP,Kamerzell TJ,Dawn B

更新日期：2012-01-01 00:00:00

abstract：:Stem cell differentiation into a variety of lineages is known to involve signaling from the extracellular niche, including from the physical properties of that environment. What regulates stem cell responses to these cues is there ability to activate different mechanotransductive pathways. Here, we will review the str...

journal_title：Progress in molecular biology and translational science

authors： Kaushik G,Engler AJ

更新日期：2014-01-01 00:00:00