Abstract：
:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular mechanisms of Treg suppressive function in the Type 1 diabetes setting, citing evidence that Treg can function in both the pancreatic lymph nodes and within the pancreatic lesion. Involvement of the CTLA-4 pathway, as well as TGF-β and IL-2 deprivation will be considered. Finally, we summarize current efforts to manipulate Treg therapeutically in individuals with Type 1 diabetes. The translation of this research area from bench to bedside is still in its infancy, but the remarkable therapeutic potential of successfully manipulating Treg populations is clear to see.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Ovcinnikovs V,Walker LSdoi
10.1016/bs.pmbts.2015.08.004subject
Has Abstractpub_date
2015-01-01 00:00:00pages
245-77eissn
1877-1173issn
1878-0814pii
S1877-1173(15)00187-8journal_volume
136pub_type
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
