Abstract：
:DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review the mechanisms of DNA methylation, including the genetic and environmental factors affecting methylation changes. We report and discuss major findings regarding DNA methylation in psychiatric patients, both within the context of global methylation studies and gene-specific methylation studies. Finally, we discuss issues surrounding data quality improvement, the limitations of current methylation analysis methods, and the possibility of using DNA methylation-based treatment for psychiatric disorders in the future.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Liu C,Jiao C,Wang K,Yuan Ndoi
10.1016/bs.pmbts.2018.01.006subject
Has Abstractpub_date
2018-01-01 00:00:00pages
175-232eissn
1877-1173issn
1878-0814pii
S1877-1173(18)30019-Xjournal_volume
157pub_type
杂志文章,评审abstract：:Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the rol...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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abstract：:Obesity is a condition in which excess body fat has accumulated over an extent that increases the risk of many chronic diseases. The current clinical classification of obesity is based on measurement of body mass index (BMI), waist-hip ratio, and body fat percentage. However, these measurements do not account for the ...
journal_title：Progress in molecular biology and translational science
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abstract：:Mechanotransduction, the conversion of a mechanical stimulus into an electrical signal, is a central mechanism to several physiological functions in mammals. It relies on the function of mechanosensitive ion channels (MSCs). Although the first single-channel recording from MSCs dates back to 30 years ago, the identity...
journal_title：Progress in molecular biology and translational science
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abstract：:In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...
journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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abstract：:Arrestins are a small protein family with only four members in mammals. Arrestins demonstrate an amazing versatility, interacting with hundreds of different G protein-coupled receptor (GPCR) subtypes, numerous nonreceptor signaling proteins, and components of the internalization machinery, as well as cytoskeletal elem...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-387685-0.00013-5
更新日期：2011-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.04.023
更新日期：2020-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.03.005
更新日期：2019-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2017.07.002
更新日期：2017-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-396456-4.00002-X
更新日期：2012-01-01 00:00:00
abstract：:Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-spec...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-385071-3.00005-8
更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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doi：10.1016/bs.pmbts.2020.02.004
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
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abstract：:Reported exposure to traumatic event is relatively common within the general population (40-90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD). Indeed, the lifetime prevalence of PTSD is estimated to range between 7% and 12%. The factors influencing risk or resilience to PTSD af...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families ex...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-415795-8.00002-7
更新日期：2011-01-01 00:00:00
