Abstract：
:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental risk factors. However, the translation of preclinical data into suitable drug targets must overcome three critical hurdles: (i) ASD comprises a highly heterogeneous group of conditions that can markedly differ in terms of their clinical presentation and symptoms, (ii) the plethora of genetic and environmental risk factors suggests a complex, non-unitary, etiopathology, and (iii) the lack of consensus over the myriad of preclinical models, with respect to both construct validity and face validity. Against this backdrop, this Chapter traces how the endocannabinoid system (ECS) has emerged as a promising target for intervention with predictive validity. Recent supportive preclinical evidence is summarized, especially studies in mice demonstrating the emergence of ASD-like behaviors following diverse genetic or pharmacological manipulations targeting the ECS. The critical relevance of ECS to the complex pathogenesis of ASD is underscored by its multiple roles in modulating neuronal functions and shaping brain development. Finally, we argue that important lessons have been learned from the novel mouse models of ASD, which not only stimulate game-changing innovative treatments but also foster a consensual framework to integrate the diverse approaches applied in the search of novel treatments for ASD.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Pietropaolo S,Bellocchio L,Bouzón-Arnáiz I,Yee BKdoi
10.1016/bs.pmbts.2020.04.016subject
Has Abstractpub_date
2020-01-01 00:00:00pages
183-208eissn
1877-1173issn
1878-0814pii
S1877-1173(20)30060-0journal_volume
173pub_type
杂志文章abstract：:Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammar...
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2011-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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更新日期：2013-01-01 00:00:00
abstract：:Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current ...
journal_title：Progress in molecular biology and translational science
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doi：10.1016/bs.pmbts.2018.04.008
更新日期：2018-01-01 00:00:00
