Regulation of metabolism by nuclear hormone receptors.

abstract：:Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and the destruction of extracellular matrix (ECM). Furthermore...

journal_title：Progress in molecular biology and translational science

authors： Rabkin SW

更新日期：2017-01-01 00:00:00

abstract：:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular m...

journal_title：Progress in molecular biology and translational science

authors： Ovcinnikovs V,Walker LS

更新日期：2015-01-01 00:00:00

abstract：:Transmissible spongiform encephalopathies or prion diseases describe a number of different human disorders that differ in their clinical phenotypes, which are nonetheless united by their transmissible nature and common pathology. Clinical variation in the absence of a conventional infectious agent is believed to be en...

journal_title：Progress in molecular biology and translational science

authors： Ellett LJ,Revill ZT,Koo YQ,Lawson VA

更新日期：2020-01-01 00:00:00

abstract：:Transition metals such as manganese are essential nutrients for both pathogen and host. Vertebrates exploit this necessity to combat invading microbes by restricting access to these critical nutrients, a defense known as nutritional immunity. During infection, the host uses several mechanisms to impose manganese limit...

journal_title：Progress in molecular biology and translational science

authors： Kelliher JL,Kehl-Fie TE

更新日期：2016-01-01 00:00:00

abstract：:Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic pat...

journal_title：Progress in molecular biology and translational science

authors： Wang X,Zhang R,Zhang L,Tian Z

更新日期：2019-01-01 00:00:00

abstract：:Ndsts (N-deacetylase/N-sulfotransferases) are enzymes responsible for N-sulfation during heparan sulfate (HS) and heparin biosynthesis. In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented. Effects of Ndst1 deficiency on embryonic dev...

journal_title：Progress in molecular biology and translational science

authors： Ringvall M,Kjellén L

更新日期：2010-01-01 00:00:00

abstract：:DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review t...

journal_title：Progress in molecular biology and translational science

authors： Liu C,Jiao C,Wang K,Yuan N

更新日期：2018-01-01 00:00:00

abstract：:A metaplastic change where normal squamous mucosa of the esophagus is replaced by columnar mucosa is considered an adaptive process to withstand the chronic gastroesophageal reflux injury. However, this phenotypic switch in the esophageal mucosa is associated with an increased propensity to undergo neoplastic transfor...

journal_title：Progress in molecular biology and translational science

authors： Singh A,Demars C,Buttar NS

更新日期：2010-01-01 00:00:00

abstract：:Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns ...

journal_title：Progress in molecular biology and translational science

authors： Taneyhill LA,Schiffmacher AT

更新日期：2013-01-01 00:00:00

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attempt to understand hammerhead ribozyme catalysis in terms of structure....

journal_title：Progress in molecular biology and translational science

authors： Scott WG,Horan LH,Martick M

更新日期：2013-01-01 00:00:00

abstract：:Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of importa...

journal_title：Progress in molecular biology and translational science

authors： Terzi D,Stergiou E,King SL,Zachariou V

更新日期：2009-01-01 00:00:00

abstract：:In 1982, the Cech group discovered that an intron structure in an rRNA precursor of Tetrahymena thermophila is sufficient to complete splicing without assistance from proteins. This was the first moment that scientists recognized RNAs can have catalytic activities derived from their own unique three-dimensional struct...

journal_title：Progress in molecular biology and translational science

authors： Lee CH,Han SR,Lee SW

更新日期：2018-01-01 00:00:00

abstract：:-1 Programmed ribosomal frameshifting is a translational recoding event in which ribosomes slip backward along messenger RNA presumably due to increased tension disrupting the codon-anticodon interaction at the ribosome's coding site. Single-molecule physical methods and recent experiments characterizing the physical ...

journal_title：Progress in molecular biology and translational science

authors： Visscher K

更新日期：2016-01-01 00:00:00

abstract：:Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino ...

journal_title：Progress in molecular biology and translational science

authors： Nguyen PH,Sterpone F,Derreumaux P

更新日期：2020-01-01 00:00:00

abstract：:The production of transgenic mice expressing different forms of the prion protein (PrP) or devoid of PrP has enabled researchers to study the role of PrP in the infectious process of a prion disease and its normal function in the healthy individual. A wide range of transgenic models have been produced ranging from PrP...

journal_title：Progress in molecular biology and translational science

authors： Diack AB,Alibhai JD,Manson JC

更新日期：2017-01-01 00:00:00

abstract：:The innate immune system senses microbial infections using pattern-recognition receptors and signals to activate adaptive immunity. Type I transmembrane protein Toll-like receptors (TLRs) play important roles in antimicrobial immune responses. Upon the recognition of pathogen-associated molecular patterns, TLRs homo- ...

journal_title：Progress in molecular biology and translational science

authors： Matsumoto M,Funami K,Oshiumi H,Seya T

更新日期：2013-01-01 00:00:00

abstract：:Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may b...

journal_title：Progress in molecular biology and translational science

authors： Zhang X,Li JP

更新日期：2010-01-01 00:00:00

abstract：:Experimental data accumulated during the last 10 years strongly support the existence and functional significance of oligomerization of G protein-coupled receptors (GPCRs). In this essay, we discuss the unique biochemical properties of GPCR oligomers in the frame of "allosterism" and how these properties can be used t...

journal_title：Progress in molecular biology and translational science

authors： Ferré S,Ciruela F,Casadó V,Pardo L

更新日期：2020-01-01 00:00:00

abstract：:The pituitary gonadotrope is central to reproductive function. Gonadotropes develop in a systematic process dependent on signaling factors secreted from surrounding tissues and those produced within the pituitary gland itself. These signaling pathways are important for stimulating specific transcription factors that u...

journal_title：Progress in molecular biology and translational science

authors： Stallings CE,Kapali J,Ellsworth BS

更新日期：2016-01-01 00:00:00

abstract：:Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life events, such as childhood maltreatment, has been linked to...

journal_title：Progress in molecular biology and translational science

authors： Dick A,Provencal N

更新日期：2018-01-01 00:00:00

abstract：:Being responsible for more than 90% of cellular functions, protein molecules are workhorses in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt diverse structures that allow them to perform myriad of functions. Beginning with the genetically directed amino acid sequence, the...

journal_title：Progress in molecular biology and translational science

authors： Bhopatkar AA,Uversky VN,Rangachari V

更新日期：2020-01-01 00:00:00

abstract：:Immunoproteasomes contain replacements for the three catalytic subunits of standard proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that lead to elevated production of immunoproteasomes. Immune system cells, especially antigen-presenting cells, express a higher basal level of imm...

journal_title：Progress in molecular biology and translational science

authors： Ferrington DA,Gregerson DS

更新日期：2012-01-01 00:00:00

abstract：:The liver is the largest glandular organ in the body and plays a central role in controlling metabolism. During hepatogenesis, complex developmental processes must generate an array of cell types that are spatially arranged to generate a hepatic architecture that is essential to support liver function. The processes t...

journal_title：Progress in molecular biology and translational science

authors： Nagaoka M,Duncan SA

更新日期：2010-01-01 00:00:00

abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...

journal_title：Progress in molecular biology and translational science

authors： He Y,Zhang L,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Accumulating evidence showed that the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is an essential regulator of sexual development and reproduction from zebrafish to human. Activating and inactivating mutations of LHCGR gene have been identified from patients of different phenotypes. Familial male-limit...

journal_title：Progress in molecular biology and translational science

authors： Qiao J,Han B

更新日期：2019-01-01 00:00:00

abstract：:Skeletal muscle and white adipose tissue are the largest organs in the human body and both tissues act as endocrine organs capable of secreting many bioactive molecules. There has been some confusion about nomenclature and we suggest that the name myokine should be restricted to a protein or molecule secreted from myo...

journal_title：Progress in molecular biology and translational science

authors： Görgens SW,Eckardt K,Jensen J,Drevon CA,Eckel J

更新日期：2015-01-01 00:00:00

abstract：:Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the rol...

journal_title：Progress in molecular biology and translational science

authors： Bodelon C,Savage SA,Gadalla SM

更新日期：2014-01-01 00:00:00

abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...

journal_title：Progress in molecular biology and translational science

authors： Thorburn A

更新日期：2020-01-01 00:00:00

abstract：:In today's world of genomics and large computational analyses, rapid progress has been made in identifying genes associated with human retinal diseases. Nevertheless, before significant advances toward effective therapeutic intervention is made, a clearer understanding of the molecular and cellular role of these gene ...

journal_title：Progress in molecular biology and translational science

authors： Cook T,Zelhof A,Mishra M,Nie J

更新日期：2011-01-01 00:00:00