Abstract:
:Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the role that these genetic structures have in disease risk and mortality in human populations. This chapter provides an overview of the current telomere epidemiology research and discusses approaches taken in these investigations. We also highlight important methodological considerations that may affect data interpretation.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Bodelon C,Savage SA,Gadalla SMdoi
10.1016/B978-0-12-397898-1.00005-0subject
Has Abstractpub_date
2014-01-01 00:00:00pages
113-31eissn
1877-1173issn
1878-0814pii
B978-0-12-397898-1.00005-0journal_volume
125pub_type
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更新日期:2012-01-01 00:00:00
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journal_title:Progress in molecular biology and translational science
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