Abstract：
:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of the patient. Over recent years, a number of therapies have been developed against numerous molecular targets in cancers. Kinase inhibitors and monoclonal antibodies have been shown to target numerous kinases, growth factor receptors, and cell signaling pathways. This can lead to effects on tumor cell growth, angiogenesis, apoptosis, and the microenvironment. Most recent findings are very promising as they relate to the use of immunotherapy to treat certain cancers. Immune checkpoint inhibitors and cancer vaccines are currently being investigated. In this review, we will highlight some novel molecular targeted strategies that are being used or considered as potential therapeutics to treat patients with pancreatic cancer.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Baines AT,Martin PM,Rorie CJdoi
10.1016/bs.pmbts.2016.09.006subject
Has Abstractpub_date
2016-01-01 00:00:00pages
277-320eissn
1877-1173issn
1878-0814pii
S1877-1173(16)30075-8journal_volume
144pub_type
杂志文章,评审abstract：:Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of importa...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(09)86010-9
更新日期：2009-01-01 00:00:00
abstract：:In today's world of genomics and large computational analyses, rapid progress has been made in identifying genes associated with human retinal diseases. Nevertheless, before significant advances toward effective therapeutic intervention is made, a clearer understanding of the molecular and cellular role of these gene ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-384878-9.00008-X
更新日期：2011-01-01 00:00:00
abstract：:Mitochondria are well-known cellular organelles that play a vital role in cellular bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism, and other metabolic activities. Given the extensive role of mitochondria in cell function, mitochondrial dysfunction plays a part in many diseases, ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2016.12.019
更新日期：2017-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that have emerged in recent years as central regulators of eukaryotic gene expression. In mammalian systems, miRNAs are associated with numerous pathological and physiological pathways. miRNAs are important in many viral infections, with different viral families ex...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-415795-8.00002-7
更新日期：2011-01-01 00:00:00
abstract：:Reported exposure to traumatic event is relatively common within the general population (40-90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD). Indeed, the lifetime prevalence of PTSD is estimated to range between 7% and 12%. The factors influencing risk or resilience to PTSD af...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-800977-2.00002-4
更新日期：2014-01-01 00:00:00
abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.05.005
更新日期：2019-01-01 00:00:00
abstract：:The increased prevalence of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, and fatty liver disease has provided increasingly negative connotations toward lipids. However, it is important to remember that lipids are essential components supporting life. Lipids are a class of molecules defined by their inhe...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.06.017
更新日期：2015-01-01 00:00:00
abstract：:The control of immune responses against self and nonharmful environmental antigens is of critical importance to the immune homeostasis. Regulatory T (Treg) cells are the key players of such immune regulation and their deficiency and dysfunction are associated with various immune disorders, such as autoimmunity and all...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.07.011
更新日期：2015-01-01 00:00:00
abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394440-5.00013-9
更新日期：2013-01-01 00:00:00
abstract：:Carbon nanotubes (CNTs) are cylinder-shaped allotropic forms of carbon, most widely produced under chemical vapor deposition. They possess astounding chemical, electronic, mechanical, and optical properties. Being among the most promising materials in nanotechnology, they are also likely to revolutionize medicine. Amo...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-416020-0.00005-X
更新日期：2011-01-01 00:00:00
abstract：:Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic pat...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2019.01.007
更新日期：2019-01-01 00:00:00
abstract：:Dynamic adaptation to stressful life events requires the co-ordinated action of the central stress response, which is mediated by the hypothalamic-pituitary-adrenal (HPA) axis, to restore and maintain homeostasis. Excessive exposure to stress or traumatic life events, such as childhood maltreatment, has been linked to...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2018.04.006
更新日期：2018-01-01 00:00:00
abstract：:In this chapter, we describe how to create mathematical models of synaptic transmission and integration. We start with a brief synopsis of the experimental evidence underlying our current understanding of synaptic transmission. We then describe synaptic transmission at a particular glutamatergic synapse in the mammali...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-397897-4.00004-8
更新日期：2014-01-01 00:00:00
abstract：:Being responsible for more than 90% of cellular functions, protein molecules are workhorses in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt diverse structures that allow them to perform myriad of functions. Beginning with the genetically directed amino acid sequence, the...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.06.001
更新日期：2020-01-01 00:00:00
abstract：:Ribosomal protein S6 kinase (S6K) has been implicated in the phosphorylation of multiple substrates and is subject to activation by a wide variety of signals that converge at mammalian target of rapamycin (mTOR). In the course of the search for its physiological role, it was proposed that S6K activation and ribosomal ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S1877-1173(09)90003-5
更新日期：2009-01-01 00:00:00
abstract：:Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammar...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2017.11.020
更新日期：2018-01-01 00:00:00
abstract：:A substantive volume of research on autism spectrum disorder (ASD) has emerged in recent years adding to our understanding of the etiopathological process. Preclinical models in mice and rats have been highly instrumental in modeling and dissecting the contributions of a multitude of known genetic and environmental ri...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.04.016
更新日期：2020-01-01 00:00:00
abstract：:As obligate parasites of cellular processes, viruses must take over cellular macromolecular machinery. It is also becoming clear that viruses routinely control intracellular signaling pathways through the direct or indirect control of kinases and phosphatases. This control of cellular phosphoproteins is important to p...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-396456-4.00002-X
更新日期：2012-01-01 00:00:00
abstract：:Pathologic aggregates of tau protein are observed in several neurodegenerative diseases and are used to diagnose and stage disease postmortem. Recent advances in positron emission tomography radioligands allow for the detection of aggregated tau proteins in living persons. This chapter describes the development and ch...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.07.007
更新日期：2019-01-01 00:00:00
abstract：:In this chapter, I shall discuss the genetics, mode of inheritance and molecular origin of several corneal dystrophies. ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.04.004
更新日期：2015-01-01 00:00:00
abstract：:Immunoproteasomes contain replacements for the three catalytic subunits of standard proteasomes. In most cells, oxidative stress and proinflammatory cytokines are stimuli that lead to elevated production of immunoproteasomes. Immune system cells, especially antigen-presenting cells, express a higher basal level of imm...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-397863-9.00003-1
更新日期：2012-01-01 00:00:00
abstract：:Cerebral amyloid angiopathy (CAA) is commonly found in older people and in patients with Alzheimer's disease (AD) accompanying cerebrovascular disorders and dementia. Early-onset CAA cases generally have been found only in rare genetic forms of CAA. Interestingly, however, CAA-related hemorrhages have been recently re...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.05.012
更新日期：2019-01-01 00:00:00
abstract：:Parkinson's disease (PD) devastates 6.3 million people, ranking it as one of the most prevalent neurodegenerative motor disorders worldwide. PD patients may manifest symptoms of postural instability, bradykinesia, and resting tremors as a result of increasing α-synuclein aggregation and neuron death with disease progr...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2019.06.007
更新日期：2019-01-01 00:00:00
abstract：:G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy termin...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-386931-9.00008-8
更新日期：2013-01-01 00:00:00
abstract：:Escherichia coli contains a large number of suicide or toxin genes, whose expression leads to cell growth arrest and eventual cell death. One such toxin, MazF, is an ACA-specific endoribonuclease, termed "mRNA interferase."E. coli contains other mRNA interferases with different sequence specificities, which are consid...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/S0079-6603(08)00812-X
更新日期：2009-01-01 00:00:00
abstract：:The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
doi：10.1016/bs.pmbts.2020.02.001
更新日期：2020-01-01 00:00:00
abstract：:Over the last two centuries, the discovery and understanding of the principle of fluorescence have provided new means of characterizing physical/biological/chemical processes in a noninvasive manner. Fluorescence spectroscopy has become one of the most powerful and widely applied methods in the life sciences, from fun...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-386932-6.00004-1
更新日期：2013-01-01 00:00:00
abstract：:Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current ...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2018.04.008
更新日期：2018-01-01 00:00:00
abstract：:High blood pressure (BP) is a complex trait determined by both genetic and environmental factors, as well as the interactions between these factors. Over the past few decades, there has been substantial progress in elucidating the genetic determinants underlying the BP response to sodium intake, or BP salt sensitivity...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-398397-8.00010-1
更新日期：2012-01-01 00:00:00
abstract：:Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration. The bis-retino...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/bs.pmbts.2015.06.005
更新日期：2015-01-01 00:00:00
