Abstract：
:The muscular dystrophies (MDs) represent a diverse collection of inherited human disorders, which affect to varying degrees skeletal, cardiac, and sometimes smooth muscle (Emery, 2002). To date, more than 50 different genes have been implicated as causing one or more types of MD (Bansal et al., 2003). In many cases, invaluable insights into disease mechanisms, structure and function of gene products, and approaches for therapeutic interventions have benefited from the study of animal models of the different MDs (Arnett et al., 2009). The large number of genes that are associated with MD and the tremendous number of animal models that have been developed preclude a complete discussion of each in the context of this review. However, we summarize here a number of the more commonly used models together with a mixture of different types of gene and MD, which serves to give a general overview of the value of animal models of MD for research and therapeutic development.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Ng R,Banks GB,Hall JK,Muir LA,Ramos JN,Wicki J,Odom GL,Konieczny P,Seto J,Chamberlain JR,Chamberlain JSdoi
10.1016/B978-0-12-394596-9.00004-4subject
Has Abstractpub_date
2012-01-01 00:00:00pages
83-111eissn
1877-1173issn
1878-0814pii
B978-0-12-394596-9.00004-4journal_volume
105pub_type
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