Abstract:
:The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types and to participate in a number of processes during development and disease such as endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation. In this review, we summarize the current understanding about KLF2 with a focus on its effects on vascular biology.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Novodvorsky P,Chico TJdoi
10.1016/B978-0-12-386930-2.00007-0subject
Has Abstractpub_date
2014-01-01 00:00:00pages
155-88eissn
1877-1173issn
1878-0814pii
B978-0-12-386930-2.00007-0journal_volume
124pub_type
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