Abstract：
:The etiology of obesity is multifactorial, involving complex interactions among the genetic makeup, neuroendocrine status, fetal programming, and different unhealthy environmental factors, such as sedentarism or inadequate dietary habits. Among the different mechanisms causing obesity, epigenetics, defined as the study of heritable changes in gene expression that occur without a change in the DNA sequence, has emerged as a very important determinant. Experimental evidence concerning dietary factors influencing obesity development through epigenetic mechanisms has been described. Thus, identification of those individuals who present with changes in DNA methylation profiles, certain histone modifications, or other epigenetically related processes could help to predict their susceptibility to gain or lose weight. Indeed, research concerning epigenetic mechanisms affecting weight homeostasis may play a role in the prevention of excessive fat deposition, the prediction of the most appropriate weight reduction plan, and the implementation of newer therapeutic approaches.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Campión J,Milagro F,Martínez JAdoi
10.1016/B978-0-12-375003-7.00011-Xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
291-347eissn
1877-1173issn
1878-0814pii
B978-0-12-375003-7.00011-Xjournal_volume
94pub_type
杂志文章,评审abstract：:Attention has been focused on Wnt signaling in the mouse mammary gland for several decades, firstly by the discovery of several Wnt loci among the oncogenes revealed by MMTV-based insertional mutagenesis screening of mouse mammary gland, and then by the remarkable visualization of Wnt-dependent specification of mammar...
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abstract：:Telomeres are long nucleotide repeats and protein complexes at the ends of chromosomes that are essential for maintaining chromosomal stability. They shorten with each cell division, and therefore, telomere length is a marker for cellular aging and senescence. Epidemiological research of telomeres investigates the rol...
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更新日期：2014-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
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更新日期：2014-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-394440-5.00003-6
更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2012-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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更新日期：2013-01-01 00:00:00
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doi：10.1016/bs.pmbts.2015.07.011
更新日期：2015-01-01 00:00:00
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abstract：:Phylogeny indicates that in mammals memory CD4-dependent antibody responses evolved after monotremes split from the common ancestor of marsupial and eutherian mammals. This was strongly associated with the development of segregated B and T cell areas and the development of a linked lymph node network. The evolution of...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2015-01-01 00:00:00
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abstract：:Cadherin-based cell-cell adhesions are dynamic structures that mediate tissue organization and morphogenesis. They link cells together, mediate cell-cell recognition, and influence cell shape, motility, proliferation, and differentiation. At the cellular level, operation of classical cadherin adhesion systems is coord...
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更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
abstract：:The Wnt family of secreted glycoproteins participates in a wide array of biological processes, including cellular differentiation, proliferation, survival, apoptosis, adhesion, angiogenesis, hypertrophy, and aging. The canonical Wnt signaling primarily utilizes β-catenin-mediated activation of transcription, while the...
journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-398459-3.00007-1
更新日期：2012-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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更新日期：2020-01-01 00:00:00
