Early detection and personalized medicine: Future strategies against Alzheimer's disease.

abstract：:Since the discovery of specialized T cells with regulatory function, harnessing the power of these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence that regulatory T cells (Treg) can inhibit Type 1 diabetes in animal models and humans. We discuss the anatomical sites and molecular m...

journal_title：Progress in molecular biology and translational science

authors： Ovcinnikovs V,Walker LS

更新日期：2015-01-01 00:00:00

abstract：:The development of chronic lung disease occurs as a consequence of multiple cellular events that involve an initial insult which often leads to the development of chronic inflammation, and the dysregulation of cellular proliferation and cell death mechanisms. Multiple cell types in the lung are key to the respiratory ...

journal_title：Progress in molecular biology and translational science

authors： Racanelli AC,Choi AMK,Choi ME

更新日期：2020-01-01 00:00:00

abstract：:Experimental data accumulated during the last 10 years strongly support the existence and functional significance of oligomerization of G protein-coupled receptors (GPCRs). In this essay, we discuss the unique biochemical properties of GPCR oligomers in the frame of "allosterism" and how these properties can be used t...

journal_title：Progress in molecular biology and translational science

authors： Ferré S,Ciruela F,Casadó V,Pardo L

更新日期：2020-01-01 00:00:00

abstract：:Insulin resistance plays a key role in the development of type 2 diabetes mellitus and is also associated with several other diseases, such as obesity, hypertension, and cardiovascular diseases. Type 2 diabetes and obesity have become epidemic worldwide in the past few decades, and epidemiological and metabolic eviden...

journal_title：Progress in molecular biology and translational science

authors： Rachek LI

更新日期：2014-01-01 00:00:00

abstract：:A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proporti...

journal_title：Progress in molecular biology and translational science

authors： Goodfellow JA,Willison HJ

更新日期：2018-01-01 00:00:00

abstract：:The hair follicle has been known, since 1990, to contain stem cells located in the bulge area. In 2003, we reported a new type of stem cell in the hair follicle that expresses the brain stem-cell marker nestin. We have termed these cells as hair-follicle-associated pluripotent (HAP) stem cells. HAP stem cells can diff...

journal_title：Progress in molecular biology and translational science

authors： Hoffman RM,Amoh Y

更新日期：2018-01-01 00:00:00

abstract：:Midbrain dopamine neurons are pacemakers in vitro, but in vivo they fire less regularly and occasionally in bursts that can lead to a temporary cessation in firing produced by depolarization block. The therapeutic efficacy of antipsychotic drugs used to treat the positive symptoms of schizophrenia has been attributed ...

journal_title：Progress in molecular biology and translational science

authors： Yu N,Tucker KR,Levitan ES,Shepard PD,Canavier CC

更新日期：2014-01-01 00:00:00

abstract：:The worldwide epidemic of metabolic disease indicates that a better understanding of the pathways contributing to the pathogenesis of this constellation of diseases need to be determined. Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors that control development, differentiatio...

journal_title：Progress in molecular biology and translational science

authors： Huang HJ,Schulman IG

更新日期：2009-01-01 00:00:00

abstract：:The cardiorenal metabolic syndrome (CRS) consists of a constellation of cardiac, renal, and metabolic disorders including insulin resistance (IR), obesity, metabolic dyslipidemia, high-blood pressure, and evidence of early cardiac and renal disease. Mitochondria dysfunction often occurs in the CRS, and this dysfunctio...

journal_title：Progress in molecular biology and translational science

authors： Jia G,Aroor AR,Sowers JR

更新日期：2014-01-01 00:00:00

abstract：:The production of transgenic mice expressing different forms of the prion protein (PrP) or devoid of PrP has enabled researchers to study the role of PrP in the infectious process of a prion disease and its normal function in the healthy individual. A wide range of transgenic models have been produced ranging from PrP...

journal_title：Progress in molecular biology and translational science

authors： Diack AB,Alibhai JD,Manson JC

更新日期：2017-01-01 00:00:00

abstract：:In today's world of genomics and large computational analyses, rapid progress has been made in identifying genes associated with human retinal diseases. Nevertheless, before significant advances toward effective therapeutic intervention is made, a clearer understanding of the molecular and cellular role of these gene ...

journal_title：Progress in molecular biology and translational science

authors： Cook T,Zelhof A,Mishra M,Nie J

更新日期：2011-01-01 00:00:00

abstract：:Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration. The bis-retino...

journal_title：Progress in molecular biology and translational science

authors： Crouch RK,Koutalos Y,Kono M,Schey K,Ablonczy Z

更新日期：2015-01-01 00:00:00

abstract：:Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and periph...

journal_title：Progress in molecular biology and translational science

authors： Fu L,Kettner NM

更新日期：2013-01-01 00:00:00

abstract：:Transition metals such as manganese are essential nutrients for both pathogen and host. Vertebrates exploit this necessity to combat invading microbes by restricting access to these critical nutrients, a defense known as nutritional immunity. During infection, the host uses several mechanisms to impose manganese limit...

journal_title：Progress in molecular biology and translational science

authors： Kelliher JL,Kehl-Fie TE

更新日期：2016-01-01 00:00:00

abstract：:G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy termin...

journal_title：Progress in molecular biology and translational science

authors： Moreno JL,Holloway T,González-Maeso J

更新日期：2013-01-01 00:00:00

abstract：:Carbon nanotubes (CNTs) are cylinder-shaped allotropic forms of carbon, most widely produced under chemical vapor deposition. They possess astounding chemical, electronic, mechanical, and optical properties. Being among the most promising materials in nanotechnology, they are also likely to revolutionize medicine. Amo...

journal_title：Progress in molecular biology and translational science

authors： Gomez-Gualdrón DA,Burgos JC,Yu J,Balbuena PB

更新日期：2011-01-01 00:00:00

abstract：:Ndsts (N-deacetylase/N-sulfotransferases) are enzymes responsible for N-sulfation during heparan sulfate (HS) and heparin biosynthesis. In this review, basic features of the Ndst1 enzyme are covered and a brief description of HS biosynthesis and its regulation is presented. Effects of Ndst1 deficiency on embryonic dev...

journal_title：Progress in molecular biology and translational science

authors： Ringvall M,Kjellén L

更新日期：2010-01-01 00:00:00

abstract：:Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns ...

journal_title：Progress in molecular biology and translational science

authors： Taneyhill LA,Schiffmacher AT

更新日期：2013-01-01 00:00:00

abstract：:Cell-surface receptors govern the critical information passage from outside to inside the cell and hence control important cellular decisions such as survival, growth, and differentiation. These receptors, structurally grouped into different families, utilize common intracellular signaling-proteins and pathways, yet p...

journal_title：Progress in molecular biology and translational science

authors： Girnita L,Takahashi SI,Crudden C,Fukushima T,Worrall C,Furuta H,Yoshihara H,Hakuno F,Girnita A

更新日期：2016-01-01 00:00:00

abstract：:Neurodegenerative diseases are complex, progressive disorders and affect millions of people worldwide, contributing significantly to the global burden of disease. In recent years, research has begun to investigate epigenetic mechanisms for a potential role in disease etiology. In this chapter, we describe the current ...

journal_title：Progress in molecular biology and translational science

authors： Lardenoije R,Pishva E,Lunnon K,van den Hove DL

更新日期：2018-01-01 00:00:00

abstract：:Guanine nucleotide-binding proteins of the inhibitory (Gi/o) class play critical physiological roles and the receptors that activate them are important therapeutic targets (e.g., mu opioid, serotonin 5HT1a, etc.). Gi/o proteins are negatively regulated by regulator of G protein signaling (RGS) proteins. The redundant ...

journal_title：Progress in molecular biology and translational science

authors： Neubig RR

更新日期：2015-01-01 00:00:00

abstract：:Glycated serum protein (GSP, measured as serum fructosamine concentration in μmol/L) is a product of glycation reaction between glucose and serum proteins in the blood circulation. GSP is used along with blood glucose, glycated hemoglobin (HbA1c), and glycated albumin as indicators of glycemic control for diabetic pat...

journal_title：Progress in molecular biology and translational science

authors： Wang X,Zhang R,Zhang L,Tian Z

更新日期：2019-01-01 00:00:00

abstract：:The self-assembling protein shells of viruses have provided convenient scaffolds for the construction of many new materials with well-defined nanoscale architectures. In some cases, the native amino acid functional groups have served as nucleation sites for the deposition of metals and semiconductors, leading to organ...

journal_title：Progress in molecular biology and translational science

authors： Dedeo MT,Finley DT,Francis MB

更新日期：2011-01-01 00:00:00

abstract：:Alpha-fetoprotein (AFP) is a glycoprotein and belongs to the gene family of serum albumins. The serum AFP levels were found to be elevated in the sera of liver cancer patients in 1964 and were subsequently developed and used as a liver cancer biomarker. However, elevated serum AFP levels have been observed in patients...

journal_title：Progress in molecular biology and translational science

authors： He Y,Lu H,Zhang L

更新日期：2019-01-01 00:00:00

abstract：:The hammerhead ribozyme has long been considered a prototype for understanding RNA catalysis, but discrepancies between the earlier crystal structures of a minimal hammerhead self-cleaving motif and various biochemical investigations frustrated attempt to understand hammerhead ribozyme catalysis in terms of structure....

journal_title：Progress in molecular biology and translational science

authors： Scott WG,Horan LH,Martick M

更新日期：2013-01-01 00:00:00

abstract：:Transmissible spongiform encephalopathies or prion diseases describe a number of different human disorders that differ in their clinical phenotypes, which are nonetheless united by their transmissible nature and common pathology. Clinical variation in the absence of a conventional infectious agent is believed to be en...

journal_title：Progress in molecular biology and translational science

authors： Ellett LJ,Revill ZT,Koo YQ,Lawson VA

更新日期：2020-01-01 00:00:00

abstract：:Circulating tumor cells (CTCs) can be separated and characterized from normal hematopoietic cellular constituents by a variety of methods. Different strategies have included separation by physical characteristics, such as size or weight, or by biological characteristics, such as expression of epithelial or cancer-spec...

journal_title：Progress in molecular biology and translational science

authors： Hayes DF,Smerage JB

更新日期：2010-01-01 00:00:00

abstract：:Neuroinflammation is thought to play a key role in the development and progression of neurodegenerative diseases such as Alzheimer's disease. Positron emission tomography (PET) is an in vivo imaging technique capable of studying the biochemical processes which provide the molecular basis of disease. PET imaging of neu...

journal_title：Progress in molecular biology and translational science

authors： Janssen B,Mach RH

更新日期：2019-01-01 00:00:00

abstract：:Being responsible for more than 90% of cellular functions, protein molecules are workhorses in all the life forms. In order to cater for such a high demand, proteins have evolved to adopt diverse structures that allow them to perform myriad of functions. Beginning with the genetically directed amino acid sequence, the...

journal_title：Progress in molecular biology and translational science

authors： Bhopatkar AA,Uversky VN,Rangachari V

更新日期：2020-01-01 00:00:00

abstract：:Regulators of G protein signaling (RGS) comprise a diverse group of about 40 proteins which determine signaling amplitude and duration via modulation of receptor/G protein or receptor/effector coupling. Several members of the RGS family are expressed in the brain, where they have precise roles in regulation of importa...

journal_title：Progress in molecular biology and translational science

authors： Terzi D,Stergiou E,King SL,Zachariou V

更新日期：2009-01-01 00:00:00