Abstract：
:G protein-coupled receptors (or GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. GPCRs contain a conserved structure of seven transmembrane domains. Their amino terminus is located extracellularly, whereas the carboxy terminus extends into the cytoplasm. Accumulating evidence suggests that GPCRs exist and function as monomeric entities. Nevertheless, more recent findings indicate that GPCRs can also form dimers or even higher order oligomers. The differential pharmacological and signaling properties of GPCR heteromeric complexes hint that their physiological effects may be different as compared to those obtained in tissue cultures that express a particular GPCR. In this chapter, we review current data on the role of GPCR heteromerization in receptor signaling, as well as its potential implication in neuropsychiatric disorders such as schizophrenia, depression, and Parkinson's disease.
journal_name
Prog Mol Biol Transl Scijournal_title
Progress in molecular biology and translational scienceauthors
Moreno JL,Holloway T,González-Maeso Jdoi
10.1016/B978-0-12-386931-9.00008-8subject
Has Abstractpub_date
2013-01-01 00:00:00pages
187-205eissn
1877-1173issn
1878-0814pii
B978-0-12-386931-9.00008-8journal_volume
117pub_type
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journal_title：Progress in molecular biology and translational science
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更新日期：2013-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
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更新日期：2009-01-01 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-375003-7.00011-X
更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Progress in molecular biology and translational science
pub_type： 杂志文章,评审
doi：10.1016/B978-0-12-800101-1.00008-9
更新日期：2014-01-01 00:00:00
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更新日期：2015-01-01 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：2020-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2013-01-01 00:00:00
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更新日期：2016-01-01 00:00:00
