The Principles of protein surgery and its application to the logical drug design for the treatment of neurodegenerative diseases.

abstract：:A wide range of neuroimmunological diseases, referred to as autoimmune neuropathies, affect the peripheral nervous systems (PNS). The PNS is structurally diverse with complex anatomical compartments enriched in many different myelin and neuronal glycolipids, notably gangliosides. Autoimmune neuropathies are a proporti...

journal_title：Progress in molecular biology and translational science

authors： Goodfellow JA,Willison HJ

更新日期：2018-01-01 00:00:00

abstract：:Genomic imprinting is the phenomenon where the expression of a locus differs between the maternally and paternally inherited alleles. Typically, this manifests as transcriptional silencing of one of the alleles, although many genes are imprinted in a tissue- or isoform-specific manner. Diseases associated with imprint...

journal_title：Progress in molecular biology and translational science

authors： Wilkins JF,Úbeda F

更新日期：2011-01-01 00:00:00

abstract：:Mitochondria are well-known cellular organelles that play a vital role in cellular bioenergetics, heme biosynthesis, thermogenesis, calcium homeostasis, lipid catabolism, and other metabolic activities. Given the extensive role of mitochondria in cell function, mitochondrial dysfunction plays a part in many diseases, ...

journal_title：Progress in molecular biology and translational science

authors： Akhter F,Chen D,Yan SF,Yan SS

更新日期：2017-01-01 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disease that is characterized histopathologically by the presence of plaques, mainly composed of Abeta amyloid and the tangles, mainly composed of hyperphosphorylated tau. To date, there is no treatment that can reverse the disease, and all the current therapeutic...

journal_title：Progress in molecular biology and translational science

authors： Corbo CP,Alonso Adel C

更新日期：2011-01-01 00:00:00

abstract：:The zinc-finger transcription factor KLF2 transduces the physical forces exerted by blood flow into molecular signals responsible for a wide range of biological responses. Following its initial recognition as a flow-responsive endothelial transcription factor, KLF2 is now known to be expressed in a range of cell types...

journal_title：Progress in molecular biology and translational science

authors： Novodvorsky P,Chico TJ

更新日期：2014-01-01 00:00:00

abstract：:Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps. Japanese scholars found that Grifola frondosa polysaccharide or D-fraction is the major biologically active ingredient, which is a protein-bound glucan ...

journal_title：Progress in molecular biology and translational science

authors： He Y,Zhang L,Wang H

更新日期：2019-01-01 00:00:00

abstract：:Antidepressant drugs remain poorly understood, especially with respect to pharmacological mechanisms of action. This lack of knowledge results from the extreme complexity inherent to psychopharmacology, as well as to a corresponding lack of knowledge regarding depressive disorder pathophysiology. While the final analy...

journal_title：Progress in molecular biology and translational science

authors： Cottingham C,Ferryman CJ,Wang Q

更新日期：2015-01-01 00:00:00

abstract：:Cell-surface receptors govern the critical information passage from outside to inside the cell and hence control important cellular decisions such as survival, growth, and differentiation. These receptors, structurally grouped into different families, utilize common intracellular signaling-proteins and pathways, yet p...

journal_title：Progress in molecular biology and translational science

authors： Girnita L,Takahashi SI,Crudden C,Fukushima T,Worrall C,Furuta H,Yoshihara H,Hakuno F,Girnita A

更新日期：2016-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the major form of dementia and a growing epidemic for which no disease-modifying treatments exist. AD is characterized by the early loss of synapses in the brain and, at later stages, neuronal death accompanied with progressive loss of cognitive functions. Here we focus on the mechanisms in...

journal_title：Progress in molecular biology and translational science

authors： Loera-Valencia R,Ismail MA,Nilsson P,Winblad B

更新日期：2019-01-01 00:00:00

abstract：:The cellular recycling process of macroautophagy, which is the mechanism by which cellular material is delivered to lysosomes via double membraned vesicles called autophagosomes, is intimately connected to programmed cell death pathways, especially apoptosis. In this article, I discuss some underlying mechanisms and t...

journal_title：Progress in molecular biology and translational science

authors： Thorburn A

更新日期：2020-01-01 00:00:00

abstract：:Accumulating evidence showed that the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is an essential regulator of sexual development and reproduction from zebrafish to human. Activating and inactivating mutations of LHCGR gene have been identified from patients of different phenotypes. Familial male-limit...

journal_title：Progress in molecular biology and translational science

authors： Qiao J,Han B

更新日期：2019-01-01 00:00:00

abstract：:Most aspects of mammalian function display circadian rhythms driven by an endogenous clock. The circadian clock is operated by genes and comprises a central clock in the brain that responds to environmental cues and controls subordinate clocks in peripheral tissues via circadian output pathways. The central and periph...

journal_title：Progress in molecular biology and translational science

authors： Fu L,Kettner NM

更新日期：2013-01-01 00:00:00

abstract：:The hair follicle has been known, since 1990, to contain stem cells located in the bulge area. In 2003, we reported a new type of stem cell in the hair follicle that expresses the brain stem-cell marker nestin. We have termed these cells as hair-follicle-associated pluripotent (HAP) stem cells. HAP stem cells can diff...

journal_title：Progress in molecular biology and translational science

authors： Hoffman RM,Amoh Y

更新日期：2018-01-01 00:00:00

abstract：:DNA methylation has been an important area of research in the study of molecular mechanism to psychiatric disorders. Recent evidence has suggested that abnormalities in global methylation, methylation of genes, and pathways could play a role in the etiology of many forms of mental illness. In this article, we review t...

journal_title：Progress in molecular biology and translational science

authors： Liu C,Jiao C,Wang K,Yuan N

更新日期：2018-01-01 00:00:00

abstract：:Growing evidence suggests that imbalances in resident microbes (dysbiosis) can promote chronic inflammation, immune-subversion, and production of carcinogenic metabolites, thus leading to neoplasia. Yet, evidence to support a direct link of individual bacteria species to human sporadic cancer is still limited. This ch...

journal_title：Progress in molecular biology and translational science

authors： Silbergleit M,Vasquez AA,Miller CJ,Sun J,Kato I

更新日期：2020-01-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the principle regulator of calcium-phosphorus metabolism and bone turnover. Because of its central role in bone remodeling, recombinant human PTH (i.e., Forteo®; PTH(1-34)) has been developed for the treatment of osteoporosis. PTH(1-34) acts principally through the type I PTH/PTH-related p...

journal_title：Progress in molecular biology and translational science

authors： Bohinc BN,Gesty-Palmer D

更新日期：2013-01-01 00:00:00

abstract：:-1 Programmed ribosomal frameshifting is a translational recoding event in which ribosomes slip backward along messenger RNA presumably due to increased tension disrupting the codon-anticodon interaction at the ribosome's coding site. Single-molecule physical methods and recent experiments characterizing the physical ...

journal_title：Progress in molecular biology and translational science

authors： Visscher K

更新日期：2016-01-01 00:00:00

abstract：:Normal pregnancy is associated with marked hemodynamic and uterine changes that allow adequate uteroplacental blood flow and uterine expansion for the growing fetus. These pregnancy-associated changes involve significant uteroplacental and vascular remodeling. Matrix metalloproteinases (MMPs) are important regulators ...

journal_title：Progress in molecular biology and translational science

authors： Chen J,Khalil RA

更新日期：2017-01-01 00:00:00

abstract：:The worldwide epidemic of metabolic disease indicates that a better understanding of the pathways contributing to the pathogenesis of this constellation of diseases need to be determined. Nuclear hormone receptors comprise a superfamily of ligand-activated transcription factors that control development, differentiatio...

journal_title：Progress in molecular biology and translational science

authors： Huang HJ,Schulman IG

更新日期：2009-01-01 00:00:00

abstract：:Bombesin (Bn) is a 14-amino acid peptide isolated from the skin of the frog Bombina bombina. The mammalian homologs of this peptide include three forms of gastrin-releasing peptide (GRP): GRP-10, GRP-27, and GRP-29, and a 10-amino acid peptide referred to as neuromedin-B (NMB). These peptides evoke a number of respons...

journal_title：Progress in molecular biology and translational science

authors： Sayegh AI

更新日期：2013-01-01 00:00:00

abstract：:Protein misfolding and aggregation of amyloid proteins is the fundamental cause of more than 20 diseases. Molecular mechanisms of the self-assembly and the formation of the toxic aggregates are still elusive. Computer simulations have been intensively used to study the aggregation of amyloid peptides of various amino ...

journal_title：Progress in molecular biology and translational science

authors： Nguyen PH,Sterpone F,Derreumaux P

更新日期：2020-01-01 00:00:00

abstract：:Lipofuscin is highly fluorescent material, formed in several tissues but best studied in the eye. The accumulation of lipofuscin in the retinal pigment epithelium (RPE) is a hallmark of aging in the eye and has been implicated in various retinal degenerations, including age-related macular degeneration. The bis-retino...

journal_title：Progress in molecular biology and translational science

authors： Crouch RK,Koutalos Y,Kono M,Schey K,Ablonczy Z

更新日期：2015-01-01 00:00:00

abstract：:Signaling via G-protein-coupled receptors (GPCRs) is central for the function of biological systems. Many clinically used drugs target GPCRs directly or target molecules involved in GPCR signaling. As an alternative to targeting receptors directly, one could modulate signaling cascades downstream of receptor activatio...

journal_title：Progress in molecular biology and translational science

authors： Sjögren B,Blazer LL,Neubig RR

更新日期：2010-01-01 00:00:00

abstract：:Cell membrane-associated junctional complexes mediate cell-cell adhesion, intercellular interactions, and other fundamental processes required for proper embryo morphogenesis. Cadherins are calcium-dependent transmembrane proteins at the core of adherens junctions and are expressed in distinct spatiotemporal patterns ...

journal_title：Progress in molecular biology and translational science

authors： Taneyhill LA,Schiffmacher AT

更新日期：2013-01-01 00:00:00

abstract：:The increased prevalence of hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, and fatty liver disease has provided increasingly negative connotations toward lipids. However, it is important to remember that lipids are essential components supporting life. Lipids are a class of molecules defined by their inhe...

journal_title：Progress in molecular biology and translational science

authors： Noland RC

更新日期：2015-01-01 00:00:00

abstract：:Amyloids are nanoscopic ordered self-assemblies of misfolded proteins that are formed via aggregation of partially unfolded or intrinsically disordered proteins (IDPs) and are commonly linked to devastating human diseases. An enlarging body of recent research has demonstrated that certain amyloids can be beneficial an...

journal_title：Progress in molecular biology and translational science

authors： Avni A,Swasthi HM,Majumdar A,Mukhopadhyay S

更新日期：2019-01-01 00:00:00

abstract：:Among the most sensitive, specific and practical of methods for detecting prions are the real-time quaking-induced conversion (RT-QuIC) assays. These assays exploit the fundamental self-propagating activity of prions to amplify the presence of prion seeds by as much as a trillion-fold. The reactions can detect most of...

journal_title：Progress in molecular biology and translational science

authors： Caughey B,Orru CD,Groveman BR,Hughson AG,Manca M,Raymond LD,Raymond GJ,Race B,Saijo E,Kraus A

更新日期：2017-01-01 00:00:00

abstract：:With a dismal 5-year survival rate of only 8%, pancreatic cancer still remains a very lethal disease. As with most cancers, pancreatic cancer is treated with different combinations of chemotherapeutic drugs which result in side effects and potential drug resistance leading in many cases to the unfortunate demise of th...

journal_title：Progress in molecular biology and translational science

authors： Baines AT,Martin PM,Rorie CJ

更新日期：2016-01-01 00:00:00

abstract：:Single-molecule approaches permit an unrivalled view of how complex systems operate and have recently been used to understand DNA-protein interactions. These tools have enabled advances in a particularly challenging problem, the search for damaged sites on DNA. DNA repair proteins are present at the level of just a fe...

journal_title：Progress in molecular biology and translational science

authors： Kad NM,Van Houten B

更新日期：2012-01-01 00:00:00

abstract：:Reported exposure to traumatic event is relatively common within the general population (40-90%), but only a fraction of individuals will develop posttraumatic stress disorder (PTSD). Indeed, the lifetime prevalence of PTSD is estimated to range between 7% and 12%. The factors influencing risk or resilience to PTSD af...

journal_title：Progress in molecular biology and translational science

authors： Rampp C,Binder EB,Provençal N

更新日期：2014-01-01 00:00:00